Search Results - "Sosa, Melinda I."

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv by Ananthan, Subramaniam, Faaleolea, Ellen R, Goldman, Robert C, Hobrath, Judith V, Kwong, Cecil D, Laughon, Barbara E, Maddry, Joseph A, Mehta, Alka, Rasmussen, Lynn, Reynolds, Robert C, Secrist, John A, Shindo, Nice, Showe, Dustin N, Sosa, Melinda I, Suling, William J, White, E. Lucile

“…Summary There is an urgent need for the discovery and development of new antitubercular agents that target new biochemical pathways and treat drug resistant…”
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High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv by Reynolds, Robert C, Ananthan, Subramaniam, Faaleolea, Ellen, Hobrath, Judith V, Kwong, Cecil D, Maddox, Clinton, Rasmussen, Lynn, Sosa, Melinda I, Thammasuvimol, Elizabeth, White, E. Lucile, Zhang, Wei, Secrist, John A

“…Summary Kinase targets are being pursued in a variety of diseases beyond cancer, including immune and metabolic as well as viral, parasitic, fungal and…”
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Antituberculosis activity of the molecular libraries screening center network library by Maddry, Joseph A, Ananthan, Subramaniam, Goldman, Robert C, Hobrath, Judith V, Kwong, Cecil D, Maddox, Clinton, Rasmussen, Lynn, Reynolds, Robert C, Secrist, John A, Sosa, Melinda I, White, E. Lucile, Zhang, Wei

“…Summary There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant…”
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Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2 by Chung, Dong-Hoon, Jonsson, Colleen B, Tower, Nichole A, Chu, Yong-Kyu, Sahin, Ergin, Golden, Jennifer E, Noah, James W, Schroeder, Chad E, Sotsky, Julie B, Sosa, Melinda I, Cramer, Daniel E, McKellip, Sara N, Rasmussen, Lynn, White, E Lucile, Schmaljohn, Connie S, Julander, Justin G, Smith, Jeffrey M, Filone, Claire Marie, Connor, John H, Sakurai, Yasuteru, Davey, Robert A

“…Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause…”
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Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen by Maddry, Joseph A, Chen, Xi, Jonsson, Colleen B, Ananthan, Subramaniam, Hobrath, Judith, Smee, Donald F, Noah, James W, Noah, Diana, Xu, Xiaolin, Jia, Fuli, Maddox, Clinton, Sosa, Melinda I, White, E Lucile, Severson, William E

“…A highly reproducible and robust cell-based high-throughput screening (HTS) assay was adapted for screening of small molecules for antiviral activity against…”
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Abstract LB-055: High-throughput screening efforts for the identification of selective and potent inhibitors of CD38 for the treatment of hematological cancers by Botta, Davide, Dadali, Tulin, Mousseau, Betty J., Zhou, Fen, Schultz, Michael D., Zumaquero, Esther, Manouvakhova, Anna, Sosa, Melinda I., McKellip, Sara N., Woods, LaKeisha, Tower, Nichole A., Ross, Larry J., Rasmussen, Lynn, White, E. Lucille, Padmalayam, Indira, Zhang, Wei, Everts, Maaike, Augelli-Szafran, Corinne E., Bostwick, James R., Suto, Mark J., Lund, Frances E.

“…By means of a phenomenon termed “the Warburg effect,” tumor cells shift their energy production by mitochondrial oxidative phosphorylation to aerobic…”
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(S)‑N‑(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection by Moore, Blake P, Chung, Dong Hoon, Matharu, Daljit S, Golden, Jennifer E, Maddox, Clinton, Rasmussen, Lynn, Noah, James W, Sosa, Melinda I, Ananthan, Subramaniam, Tower, Nichole, A, White, E. Lucile, Jia, Fuli, Prisinzano, Thomas E, Aubé, Jeffrey, Jonsson, Colleen B, Severson, William E

“…A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a…”
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High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2) by Severson, William E, McDowell, Michael, Ananthan, Subramaniam, Chung, Dong-Hoon, Rasmussen, Lynn, Sosa, Melinda I, White, E Lucile, Noah, James, Jonsson, Colleen B

“…Using a highly reproducible and robust cell-based high-throughput screening (HTS) assay, the authors screened a 100,000-compound library at 14- and 114-microM…”
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A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus by Chung, Dong-Hoon, Moore, Blake P, Matharu, Daljit S, Golden, Jennifer E, Maddox, Clinton, Rasmussen, Lynn, Sosa, Melinda I, Ananthan, Subramaniam, White, E Lucile, Jia, Fuli, Jonsson, Colleen B, Severson, William E

“…Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children…”
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Abstract 1242: Modulating the cellular redox state by targeting the NAD glycohydrolase CD38: A novel therapeutic approach for chemosensitizing B-cell malignancies by Botta, Davide, Dadali, Tulin, Mousseau, Betty, Manouvakhova, Anna, Sosa, Melinda I., MKellip, Sara N., Woods, LaKeisha, Tower, Nichole A., Ross, Larry J., Rasmussen, Lynn, White, E Lucile, Bostwick, James R., Lund, Frances E.

“…The cellular redox state, which is controlled by the NAD/NADH and NADP/NADPH redox partners, is critical for numerous cellular activities including energy…”
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Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2: e1004213 by Chung, Dong-Hoon, Jonsson, Colleen B, Tower, Nichole A, Chu, Yong-Kyu, Sahin, Ergin, Golden, Jennifer E, Noah, James W, Schroeder, Chad E, Sotsky, Julie B, Sosa, Melinda I, Cramer, Daniel E, McKellip, Sara N, Rasmussen, Lynn, White, E Lucile, Schmaljohn, Connie S, Julander, Justin G, Smith, Jeffrey M, Filone, Claire Marie, Connor, John H, Sakurai, Yasuteru, Davey, Robert A

“…Alphaviruses present serious health threats as emerging and re-emerging viruses. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, can cause…”
Get full text