Search Results - "Sosa, Liliana del Valle"
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Changes of stem cell niche during experimental pituitary tumor development
Published in Journal of neuroendocrinology (01-12-2021)“…To investigate the putative stem cell/tumor stem cell (SC/TSC) niche contribution to hyperplasic/adenomatous pituitary lesions, we analyzed variation in the…”
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Association of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study
Published in Journal of clinical pathology (01-03-2021)“…PTP4A3 is a subclass of a protein tyrosine phosphatase super family and is expressed in a range of epithelial neoplasms. We evaluated PTP4A3 expression and its…”
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Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling
Published in International journal of pharmaceutics (15-12-2020)“…[Display omitted] •Testosterone can be loaded into GM1 micelles for delivery into the cytoplasm.•Testosterone-loaded micelles are specific modulators of…”
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Involvement of MEK/ERK1/2 and PI3K/Akt Pathways in the Refractory Behavior of GH3B6 Pituitary Tumor Cells to the Inhibitory Effect of TGFβ1
Published in Endocrinology (Philadelphia) (01-02-2015)“…Pituitary tumor cells have a poor response to the growth inhibitory effect of TGFβ1, possibly resulting from the cross talk of TGFβ/Smads signal with other…”
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Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complex
Published in Structural dynamics (Melville, N.Y.) (01-07-2015)“…Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug…”
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6
Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage
Published in Toxicology and applied pharmacology (01-10-2009)“…Bromocriptine (Bc) produces pituitary tumoral mass regression which induces the cellular death that was classically described as apoptosis. However, recent…”
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The phthalate DEHP modulates the estrogen receptors α and β increasing lactotroph cell population in female pituitary glands
Published in Chemosphere (Oxford) (01-11-2020)“…Humans are exposed to numerous endocrine disruptors on a daily basis, which may interfere with endogenous estrogens, with Di-(2-ethylhexyl) phthalate (DEHP)…”
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Vascular smooth muscle cells exhibit elevated hypoxia-inducible Factor-1α expression in human blood vessel organoids, influencing osteogenic performance
Published in Experimental cell research (15-07-2024)“…Considering the importance of alternative methodologies to animal experimentation, we propose an organoid-based biological model for in vitro blood vessel…”
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9
Pivotal role of NF-κB in cellular senescence of experimental pituitary tumours
Published in Journal of endocrinology (01-05-2020)“…The molecular mechanisms underlying the capability of pituitary tumours to avoid unregulated cell proliferation are still not well understood. However, the…”
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Trastuzumab inhibits pituitary tumor cell growth modulating the TGFB/SMAD2/3 pathway
Published in Endocrine-related cancer (01-10-2018)“…In pituitary adenomas, early recurrences and resistance to conventional pharmacotherapies are common, but the mechanisms involved are still not understood. The…”
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Evidence of cellular senescence during the development of estrogen-induced pituitary tumors
Published in Endocrine-related cancer (01-06-2015)“…Although pituitary adenomas represent 25% of intracranial tumors, they are usually benign, with the mechanisms by which these tumors usually avoid an invasive…”
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The expansion of adult stem/progenitor cells and their marker expression fluctuations are linked with pituitary plastic adaptation during gestation and lactancy
Published in American journal of physiology: endocrinology and metabolism (01-08-2016)“…Extensive evidence has revealed variations in the number of hormone-producing cells in the pituitary gland, which occur under physiological conditions such as…”
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13
The structure, molecular dynamics, and energetics of centrin-melittin complex
Published in Proteins, structure, function, and bioinformatics (01-11-2011)“…Centrin is a calcium binding protein (CaBP) belonging to the EF‐hand superfamily. As with other proteins within this family, centrin is a calcium sensor with…”
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14
Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia
Published in Experimental cell research (15-11-2013)“…Toll like receptor 4 (TLR4) has been characterized for its ability to recognize bacterial endotoxin lipopolysaccharide (LPS). Considering that infections or…”
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15
Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complexa
Published in Structural dynamics (Melville, N.Y.) (15-05-2015)“…Trifluoroacetic acid (TFA) may be the cause of the bottleneck in high resolution structure determination for protein-peptide complexes. Fragment based drug…”
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16
Crystallization and preliminary X-ray characterization of full-length Chlamydomonas reinhardtii centrin
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01-05-2008)“…Chlamydomonas reinhardtii centrin is a member of the EF‐hand calcium‐binding superfamily. It is found in the basal body complex and is important for flagellar…”
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GH3B6 Pituitary Tumor Cell Proliferation is Mediated by PKCα and PKCε via ERK 1/2-dependent Pathway
Published in Cellular physiology and biochemistry (01-01-2010)“…Background: In this report, we explored the role of PKCα and PKCε as mediators of phorbol 12-myristate13-acetate (PMA)-induced proliferation in pituitary tumor…”
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ERRATUM: Evidence of cellular senescence during the development of estrogen-induced pituitary tumors
Published in Endocrine-related cancer (01-10-2022)Get full text
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The epigenetic EZH2/H3K27me3 axis modulates lactotroph tumor cell proliferation
Published in Journal of endocrinology (01-05-2023)“…Interest in epigenetics has gained substantial momentum as a result of their identified role in the regulation of tumor progression, as well as their ability…”
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Estradiol interacts with insulin through membrane receptors to induce an antimitogenic effect on lactotroph cells
Published in Steroids (01-05-2008)“…The signaling mechanisms of estrogens interact with those of growth factors to control the pituitary gland functions. The contribution of the membrane bound…”
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