Search Results - "Sosa, Christian"
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Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1
Published in The Journal of biological chemistry (01-01-2021)“…Tripartite motif (TRIM)7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1 (GN1), the autoglucosyltransferase that…”
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A C‑Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7
Published in ACS chemical biology (19-07-2024)“…TRIM7 is a ubiquitin E3 ligase with key regulatory functions, mediating viral infection, tumor biology, innate immunity, and cellular processes, such as…”
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Enhancement by GOSPEL protein of GAPDH aggregation induced by nitric oxide donor and its inhibition by NAD
Published in FEBS letters (01-07-2016)“…Glyceraldehyde‐3‐phosphate dehydrogenase's (GAPDH's) competitor of Siah Protein Enhances Life (GOSPEL) is the protein that competes with Siah1 for binding to…”
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Criticality is an emergent property of genetic networks that exhibit evolvability
Published in PLoS computational biology (01-09-2012)“…Accumulating experimental evidence suggests that the gene regulatory networks of living organisms operate in the critical phase, namely, at the transition…”
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Dynamics of the Gene Regulatory Network of HIV-1 and the Role of Viral Non-coding RNAs on Latency Reversion
Published in Frontiers in physiology (28-09-2018)“…The use of latency reversing agents (LRAs) is currently a promising approach to eliminate latent reservoirs of HIV-1. However, this strategy has not been…”
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Multidimensional study of orofacial chronic neuropathic pain: An experimental study in rats
Published in Journal of oral research (26-10-2017)“…Orofacial neuropathic chronic pain (NCP) is frequently attributed to lesions caused by orofacial surgeries and dental treatments. There are many experimental…”
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Lung cancer in recipients after lung transplant: single-centre experience and literature review
Published in BMJ open respiratory research (01-04-2022)“…IntroductionLung cancer is a major challenge facing modern medicine. It is the leading cause of cancer-related death in the USA. Little is known of the…”
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Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia
Published in The journal of maternal-fetal & neonatal medicine (01-11-2012)“…Objective: To evaluate pulmonary growth and development after fetoscopic intraluminal tracheal occlusion (FITO) using a modified 8-mm Z-stent in an ovine model…”
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