Search Results - "Sorzano, C O S"

Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials by Herreros, D., Lederman, R. R., Krieger, J. M., Jiménez-Moreno, A., Martínez, M., Myška, D., Strelak, D., Filipovic, J., Sorzano, C. O. S., Carazo, J. M.

“…The new developments in Cryo-EM Single Particle Analysis are helping us to understand how the macromolecular structure and function meet to drive biological…”
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Scipion PKPD: an Open-Source Platform for Biopharmaceutics, Pharmacokinetics and Pharmacodynamics Data Analysis by Sorzano, C. O. S., Fonseca-Reyna, Y., de la Cruz-Moreno, M. A. Pérez

“…Purpose Biopharmaceutics examines the interrelationship of the drug’s physical/chemical properties, the dosage form (drug product) in which the drug is given,…”
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Integration of Cryo-EM Model Building Software in Scipion by Martínez, M, Jiménez-Moreno, A, Maluenda, D, Ramírez-Aportela, E, Melero, R, Cuervo, A, Conesa, P, del Caño, L, Fonseca, Y. C, Sánchez-García, R, Strelak, D, Conesa, J. J, Fernández-Giménez, E, de Isidro, F, Sorzano, C. O. S, Carazo, J. M, Marabini, R

“…Advances in cryo-electron microscopy (cryo-EM) have made it possible to obtain structures of large biological macromolecules at near-atomic resolution. This…”
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A Signal Processing Approach to Pharmacokinetic Data Analysis by Sorzano, C. O. S., Moreno, M. A. Pérez-de-la-Cruz, Martín, F. R., Montejo, C., Aguilar-Ros, A.

“…The connection between pharmacokinetic models and system theory has been established for a long time. In this approach, the drug concentration is seen as the…”
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3DEM Loupe: Analysis of macromolecular dynamics using structures from electron microscopy by Nogales-Cadenas, R, Jonic, S, Tama, F, Arteni, A A, Tabas-Madrid, D, Vázquez, M, Pascual-Montano, A, Sorzano, C O S

“…Electron microscopy (EM) provides access to structural information of macromolecular complexes in the 3-20 Å resolution range. Normal mode analysis has been…”
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Two-step demodulation based on the Gram-Schmidt orthonormalization method by Vargas, J, Quiroga, J Antonio, Sorzano, C O S, Estrada, J C, Carazo, J M

“…This Letter presents an efficient, fast, and straightforward two-step demodulating method based on a Gram-Schmidt (GS) orthonormalization approach. The…”
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Two-step interferometry by a regularized optical flow algorithm by Vargas, J, Quiroga, J Antonio, Sorzano, C O S, Estrada, J C, Carazo, J M

“…A two-step phase-shifting method, that can demodulate open- and closed-fringed patterns without local sign ambiguity is presented. The proposed method only…”
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Efficient initial volume determination from electron microscopy images of single particles by Vargas, Javier, Álvarez-Cabrera, Ana-Lucia, Marabini, Roberto, Carazo, Jose M, Sorzano, C O S

“…Structural information of macromolecular complexes provides key insights into the way they carry out their biological functions. The reconstruction process…”
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Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis by Vargas, J., Melero, R., Gómez-Blanco, J., Carazo, J. M., Sorzano, C. O. S.

“…Single Particle Analysis using cryo-electron microscopy is a structural biology technique aimed at capturing the three-dimensional (3D) conformation of…”
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Image processing tools for the validation of CryoEM maps by Sorzano, C O S, Vilas, J L, Ramírez-Aportela, E, Krieger, J, Del Hoyo, D, Herreros, D, Fernandez-Giménez, E, Marchán, D, Macías, J R, Sánchez, I, Del Caño, L, Fonseca-Reyna, Y, Conesa, P, García-Mena, A, Burguet, J, García Condado, J, Méndez García, J, Martínez, M, Muñoz-Barrutia, A, Marabini, R, Vargas, J, Carazo, J M

“…The number of maps deposited in public databases (Electron Microscopy Data Bank, EMDB) determined by cryo-electron microscopy has quickly grown in recent…”
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A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy by Conesa, P., Gómez-Blanco, J., Marabini, R., Carazo, J. M., del Caño, L., Melero, R., Kazemi, M., Vilas, J. L., de la Rosa-Trevín, J. M., Otón, J., Vargas, Javier, Sorzano, Carlos Oscar S., Cuenca, J.

“…One of the key steps in Electron Microscopy is the tomographic reconstruction of a three-dimensional (3D) map of the specimen being studied from a set of…”
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Comparing scientific performance among equals by Sorzano, C. O. S., Vargas, J., Caffarena-Fernández, G., Iriarte, A.

“…Measuring scientific performance is currently a common practice of funding agencies, fellowship evaluations and hiring institutions. However, as has already…”
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3DBIONOTES: A unified, enriched and interactive view of macromolecular information by Tabas-Madrid, D., Segura, J., Sanchez-Garcia, R., Cuenca-Alba, J., Sorzano, C.O.S., Carazo, J.M.

“…With the advent of high throughput techniques like Next Generation Sequencing, the amount of biological information for genes and proteins is growing faster…”
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BIPSPI: a method for the prediction of partner-specific protein–protein interfaces by Sanchez-Garcia, Ruben, Sorzano, C O S, Carazo, J M, Segura, Joan

“…Abstract Motivation Protein–Protein Interactions (PPI) are essentials for most cellular processes and thus, unveiling how proteins interact is a crucial…”
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Quantitative morphometrical characterization of human pronuclear zygotes by Beuchat, A., Thévenaz, P., Unser, M., Ebner, T., Senn, A., Urner, F., Germond, M., Sorzano, C.O.S.

“…BACKGROUND Identification of embryos with high implantation potential remains a challenge in in vitro fertilization (IVF). Subjective pronuclear (PN) zygote…”
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Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy by de la Rosa-Trevín, J.M., Quintana, A., del Cano, L., Zaldívar, A., Foche, I., Gutiérrez, J., Gómez-Blanco, J., Burguet-Castell, J., Cuenca-Alba, J., Abrishami, V., Vargas, J., Otón, J., Sharov, G., Vilas, J.L., Navas, J., Conesa, P., Kazemi, M., Marabini, R., Sorzano, C.O.S., Carazo, J.M.

“…In the past few years, 3D electron microscopy (3DEM) has undergone a revolution in instrumentation and methodology. One of the central players in this…”
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MicrographCleaner: A python package for cryo-EM micrograph cleaning using deep learning by Sanchez-Garcia, Ruben, Segura, Joan, Maluenda, David, Sorzano, C.O.S., Carazo, J.M.

“…Cryo-EM Single Particle Analysis workflows require tens of thousands of high-quality particle projections to unveil the three-dimensional structure of…”
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Local defocus estimation in single particle analysis in cryo-electron microscopy by Fernandez-Gimenez, E., Carazo, J.M., Sorzano, C.O.S.

“…[Display omitted] •Theoretically, local defocus estimation may lead to an improvement in the resolution.•A program to analyze and compare any local defocus…”
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Cryo-Electron Microscopy: The field of 1,000+ methods by Sorzano, C.O.S., Carazo, J.M.

“…[Display omitted] •The field is very active in methodological exploration. The whole process aims to have better and more reproducible results from all aspects…”
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Automatic determination of the handedness of single-particle maps of macromolecules solved by CryoEM by Garcia Condado, J., Muñoz-Barrutia, A., Sorzano, C.O.S.

“…[Display omitted] •HaPi (Handedness Pipeline) can automatically determine the hand of cyroEM maps.•HaPi is built by training two 3D Convolutional Neural…”
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