Search Results - "Sorski, L"

Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers by Lavon, H, Matzner, P, Benbenishty, A, Sorski, L, Rossene, E, Haldar, R, Elbaz, E, Cata, J P, Gottumukkala, V, Ben-Eliyahu, S

“…Perioperative strategies can significantly influence long-term cancer outcomes. Dexmedetomidine, an α -adrenoceptor agonist, is increasingly used…”
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Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period by Levi, B, Matzner, P, Goldfarb, Y, Sorski, L, Shaashua, L, Melamed, R, Rosenne, E, Page, G.G, Ben-Eliyahu, S

“…Highlights • Ongoing stress impaired the efficacy of CpG-C in potentiating NK activity. • Perioperative stress responses reduced the beneficial anti-metastatic…”
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77. Mechanical processing of tissue suppresses NK cytotoxicity of resident leukocytes through the release of humoral factors by Sorski, L, Melamed, R, Ben-Eliyahu, S

“…We previously reported that marginating-pulmonary (MP) cells, leukocytes which reside within and adhere to the lung capillaries, are unique in persistently…”
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Acute and innocuous CpG-C immune stimulation potentiates host resistance to hepatic metastases of colon cancer and protects against immunosuppressive effects of surgery by Sorski, L, Melamed, R, Lavon, H, Matzner, P, Rosenne, E, Ben-Eliyahu, S

“…Liver metastases are a major cause of cancer-related mortality. Marginating-hepatic (MH)-NK cells are strategically located in the liver sinusoids to…”
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In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: Potential mediating mechanisms and sex differences by Shaashua, L, Sominsky, L, Levi, B, Sorski, L, Reznick, M, Page, G.G, Ben-Eliyahu, S

“…Highlight ► Behavioral stressors, surgery, and stress hormones reduce baseline plasma IL-12 levels, novel effects that were not all evident in the induced…”
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PGE2 suppresses NK activity in vivo directly and through adrenal hormones: Effects that cannot be reflected by ex vivo assessment of NK cytotoxicity by Meron, G, Tishler, Y, Shaashua, L, Rosenne, E, Levi, B, Melamed, R, Gotlieb, N, Matzner, P, Sorski, L, Ben-Eliyahu, S

“…Highlight ► This study exemplifies the limitations of the ex vivo approach in reflecting short term effects of some stress factors on NK activity…”
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83. Variation in cytokine expression levels in different immune compartments, and organ-specific effects of stress by Sorski, L, Melamed, R, Shaashua, L, Matzner, P, Gotlieb, N, Ben-Eliyahu, S

“…Pro/anti-inflammatory cytokines are key players in the etiology of several diseases and in immune activation, and stress hormones were reported to modulate…”
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85. Whole blood, as opposed to washed blood, is resistant to suppression of NK cell cytotoxicity by stress factors: Do behavioral stressors directly suppress activity of circulating NK cells in vivo ? by Gotlieb, N, Rosenne, E, Sorski, L, Shaashua, L, Matzner, P, Ben-Eliyahu, S

“…In vitro studies assessing the impact of stress factors on immune competence employ “washed” leukocytes incubated in artificial media (e.g., PBMC in…”
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The perioperative use of the sedative dexmedetomidine in cancer patients may have detrimental effects by Lavon, H, Krigman, R, Elbaz, E, Sorski, L, Matzner, P, Shaashua, L, Benbenishty, A, Cata, J.P, Gottumukkala, V, Ben-Eliyahu, S

“…Dexmedetomidine is a widely used sedative, which activates alpha-2 adrenoceptors and exerts analgesic, sympatholytic, and anxiolytic effects. Surgery and the…”
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71. Surprise, surprise: Glucocorticoids have a minor role compared to catecholamines and prostaglandins in mediating stress and surgery-induced In vivo suppression of NK activity by Ben-Eliyahu, S, Rosenne, E, Sorski, L, Shaashua, L, Neeman, E, Matzner, P, Levi, B, Gotlieb, N

“…In vitro and ex-vivo studies indicate a profound suppression of NK cell cytotoxicity (NKCC) by glucocorticoids; while catecholamines and prostaglandins were…”
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87. The use of the newly developed synthetic TLR-4 agonistas an immuno-therapeutic agent in a cancer model by Matzner, P, Shaashua, L, Sorski, L, Levi, B, Melamed, R, Rosenne, E, Benbenishty, A, Horowitz, M, Ben-Eliyahu, S

“…Glucopyranosyl lipid adjuvant (GLA) is a newly developed FDA-approved synthetic TLR-4 agonist, differing from LPS by having a defined number, length, and…”
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123. Corticosteroids, but not catecholamines, mediate stress- and surgery-induced suppression of plasma IL-12 levels in rats: A second-phase response of stress-induced immune perturbations by Shaashua, L, Sorski, L, Levi, B, Matzner, P, Page, G, Ben-Eliyahu, S

“…We recently reported that various stress paradigms suppress plasma IL-12 levels. The aim of this study was to elucidate potential neuroendocrine mediating…”
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96. Adrenocortical regeneration following complete adrenalectomy by Gotlieb, N, Albaz, E, Shaashua, L, Sorski, L, Matzner, P, Rosenne, E, Benbenishty, A, Melamed, R, Weiman-Kelman, B, Golomb, E, Ben-Eliyahu, S

“…Laboratory rodents undergoing bilateral adrenalectomy (ADX) are commonly maintained under corticosterone replacement regimens. A prolonged study we conducted,…”
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135. Simultaneous and complementary pro- and anti-inflammatory responses of immune stimulation by CpG-C by Sorski, L, Melamed, R, Benish, M, Levi, B, Shaashua, L, Matzner, P, Ben-Eliyahu, S

“…Pro-(e.g., IL-12) and anti-inflammatory (e.g., IL-10) cytokines are believed to activate opposite responses and to be mutually inhibitory. The…”
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136. Stress jeopardizes immune stimulation by CpG-C: Attenuation by adrenalectomy, but not by receptor blockade of adrenal-secreted factors by Matzner, P, Shaashua, L, Sorski, L, Levi, B, Tishler, Y, Etzion, G, Ben-Eliyahu, S

“…Immune stimulation therapy (IST) is gaining momentum along the last decade. Improved agents, including CpG-C, have been recently developed, and were shown to…”
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The effect of β-adrenergic blockade and COX-2 inhibition on healing of colon, muscle, and skin in rats undergoing colonic anastomosis by Hazut, O, Shaashua, L, Benish, M, Levi, B, Sorski, L, Benjamin, B, Hoffman, A, Zmora, O, Ben-Eliyahu, S

“…COX inhibitors and β-adrenergic blockers were recently shown to reduce cancer progression in animal models through various mechanisms. These include the…”
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Do minimally-invasive surgical procedures reduce colorectal cancer progression? A severity-independent need for arresting surgically-induced stress responses using beta-adrenergic blockers and COX2 inhibitors by Sorski, L, Levi, B, Shaashua, L, Matzner, P, Rosenne, E, Ben-Eliyahu, S

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Stress disrupts the beneficial effects of the immunostimulatory agents IL-12 and CpG-C: Are there potential clinical ramification? by Ben-Eliyahu, S, Levi, B, Goldfarb, Y, Sorski, L, Melamed, R, Rosenne, E

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Second thoughts on the role of glucocorticoids in the in vivo suppression of NK activity following stress by Ben-Eliyahu, S, Rosenne, E, Sorski, L, Levi, B

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Prolonged stress disrupts IL-12 and CpG immunostimulatory effects by Levi, B, Goldfarb, Y, Sorski, L, Rosenne, E, Melamed, R, Ben-Eliyahu, S

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