Search Results - "Sorrentino, P."
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Sustainable Materials and their Contribution to the Sustainable Development Goals (SDGs): A Critical Review Based on an Italian Example
Published in Molecules (Basel, Switzerland) (05-03-2021)“…The Sustainable Development Goals (SDGs) have been proposed to give a possible future to humankind. Due to the multidimensional characteristic of…”
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1
Published in The New England journal of medicine (18-04-2019)“…Eight infants with SCID-X1 had multilineage immune reconstitution after autologous hematopoietic stem-cell transplantation of marrow stem cells transfected…”
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Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
Published in Science translational medicine (20-04-2016)“…X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and natural killer (NK) cell immunity caused by mutations inIL2RGencoding…”
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Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes
Published in Journal of organic chemistry (21-08-2020)“…gem-Difluoroalkenes represent valuable synthetic handles for organofluorine chemistry; however, most reactions of this substructure proceed through reactive…”
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The influence of auditory stimulation on whole body variability in healthy older adults during gait
Published in Journal of biomechanics (01-07-2024)“…Acoustic stimulation appears to be a promising strategy in reducing the risk of falling in older adults, demonstrating effectiveness in improving stability…”
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The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme
Published in The Journal of biological chemistry (04-06-2004)“…Our studies demonstrate that the ABC transporter and marker of stem and progenitor cells known as the breast cancer resistance protein (BCRP or ABCG2) confers…”
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Genotoxicity of Retroviral Integration In Hematopoietic Cells
Published in Molecular therapy (01-06-2006)“…The experience of the past 3 years, since the first case of leukemia was reported in a child cured of X-linked severe combined immunodeficiency (X-SCID) by…”
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Clinical strategies for expansion of haematopoietic stem cells
Published in Nature reviews. Immunology (01-11-2004)“…Haematopoietic stem cells (HSCs) give rise to all blood and immune cells and are used in clinical transplantation protocols to treat a wide variety of…”
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Whole-Brain Propagation Delays in Multiple Sclerosis, a Combined Tractography-Magnetoencephalography Study
Published in The Journal of neuroscience (23-11-2022)“…Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology…”
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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Published in Nature medicine (01-09-2001)“…Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed…”
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Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier
Published in Drug metabolism and disposition (01-04-2013)“…The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form…”
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Bcrp1 Gene Expression Is Required for Normal Numbers of Side Population Stem Cells in Mice, and Confers Relative Protection to Mitoxantrone in Hematopoietic Cells in vivo
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2002)“…Hematopoietic stem cells (HSCs) can be identified by a "side population" (SP) phenotype. Previous studies have implicated the ATP binding cassette transporter…”
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Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells
Published in Proceedings of the National Academy of Sciences - PNAS (21-04-2009)“…It was previously reported that the ciliary epithelium (CE) of the mammalian eye contains a rare population of cells that could produce clonogenic…”
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Abcg2 Expression Marks Tissue-Specific Stem Cells in Multiple Organs in a Mouse Progeny Tracking Model
Published in Stem cells (Dayton, Ohio) (01-02-2012)“…The side population phenotype is associated with the Hoechst dye efflux activity of the Abcg2 transporter and identifies hematopoietic stem cells (HSCs) in the…”
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Visuospatial working memory abilities in children analyzed by the bricks game task (BGT)
Published in Psychological research (01-10-2023)“…The study of the development of visuospatial memory processes is useful for devising personalized educational interventions as well as for understanding the…”
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Small molecule inhibition of RNA binding proteins in haematologic cancer
Published in RNA biology (2024)“…In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic…”
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Dynamical interactions reconfigure the gradient of cortical timescales
Published in Network neuroscience (Cambridge, Mass.) (01-01-2023)“…The functional organization of the brain is usually presented with a back-to-front gradient of timescales, reflecting regional specialization with sensory…”
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The virtual multiple sclerosis patient
Published in iScience (19-07-2024)“…Multiple sclerosis (MS) diagnosis typically involves assessing clinical symptoms, MRI findings, and ruling out alternative explanations. While myelin damage…”
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Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection
Published in Blood (21-05-2009)“…Retroviral vectors containing internal promoters, chromatin insulators, and self-inactivating (SIN) long terminal repeats (LTRs) may have significantly reduced…”
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ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Published in Cancer research (Chicago, Ill.) (15-09-2015)“…While a small number of plasma membrane ABC transporters can export chemotherapeutic drugs and confer drug resistance, it is unknown whether these transporters…”
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