Search Results - "Sorop, Oana"

The microcirculation: a key player in obesity-associated cardiovascular disease by Sorop, Oana, Olver, T Dylan, van de Wouw, Jens, Heinonen, Ilkka, van Duin, Richard W, Duncker, Dirk J, Merkus, Daphne

“…It is increasingly recognized that obesity is a risk factor for microvascular disease, involving both structural and functional changes in the…”
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Experimental animal models of coronary microvascular dysfunction by Sorop, Oana, van de Wouw, Jens, Chandler, Selena, Ohanyan, Vahagn, Tune, Johnathan D, Chilian, William M, Merkus, Daphne, Bender, Shawn B, Duncker, Dirk J

“…Abstract Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important…”
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Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets by van de Wouw, Jens, Broekhuizen, Michelle, Sorop, Oana, Joles, Jaap A., Verhaar, Marianne C., Duncker, Dirk J., Danser, A. H. Jan, Merkus, Daphne

“…Heart failure (HF) and chronic kidney disease (CKD) co-exist, and it is estimated that about 50% of HF patients suffer from CKD. Although studies have been…”
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Mechanobiology of Microvascular Function and Structure in Health and Disease: Focus on the Coronary Circulation by Brandt, Maarten M, Cheng, Caroline, Merkus, Daphne, Duncker, Dirk J, Sorop, Oana

“…The coronary microvasculature plays a key role in regulating the tight coupling between myocardial perfusion and myocardial oxygen demand across a wide range…”
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Cardiac Shear Wave Velocity Detection in the Porcine Heart by Vos, Hendrik J, van Dalen, Bas M, Heinonen, Ilkka, Bosch, Johan G, Sorop, Oana, Duncker, Dirk J, van der Steen, Antonius F.W, de Jong, Nico

“…Abstract Cardiac muscle stiffness can potentially be estimated non-invasively with shear wave elastography. Shear waves are present on the septal wall after…”
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Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease by van de Wouw, Jens, Sorop, Oana, van Drie, Ruben W. A., van Duin, Richard W. B., Nguyen, Isabel T. N., Joles, Jaap A., Verhaar, Marianne C., Merkus, Daphne, Duncker, Dirk J.

“…Comorbidities of ischemic heart disease, including diabetes mellitus (DM), hypercholesterolemia (HC) and chronic kidney disease (CKD), are associated with…”
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Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities by van de Wouw, Jens, Steenhorst, Jarno J., Sorop, Oana, van Drie, Ruben W. A., Wielopolski, Piotr A., Kleinjan, Alex, Hirsch, Alexander, Duncker, Dirk J., Merkus, Daphne

“…Pulmonary hypertension is common in heart failure with preserved ejection fraction (HFpEF). Here, we tested the hypothesis that comorbidities [diabetes…”
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Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors by van de Wouw, Jens, Sorop, Oana, van Drie, Ruben W. A., Joles, Jaap A., Danser, A. H. Jan, Verhaar, Marianne C., Merkus, Daphne, Duncker, Dirk J.

“…In the present study, we tested the hypothesis that multiple risk factors, including diabetes mellitus (DM), dyslipidaemia and chronic kidney disease (CKD)…”
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Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia by Sorop, Oana, van den Heuvel, Mieke, van Ditzhuijzen, Nienke S, de Beer, Vincent J, Heinonen, Ilkka, van Duin, Richard W B, Zhou, Zhichao, Koopmans, Sietse J, Merkus, Daphne, van der Giessen, Wim J, Danser, A H Jan, Duncker, Dirk Jan

“…Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mellitus (DM)- and hypercholesterolemia-associated coronary…”
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Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement by Heinonen, Ilkka, Sorop, Oana, van Dalen, Bas M., Wüst, Rob C. I., van de Wouw, Jens, de Beer, Vincent J., Octavia, Yanti, van Duin, Richard W. B., Hoogstrate, Youri, Blonden, Lau, Alkio, Milla, Anttila, Katja, Stubbs, Andrew, van der Velden, Jolanda, Merkus, Daphne, Duncker, Dirk J.

“…The prevalence of diabetic metabolic derangement (DMetD) has increased dramatically over the last decades. Although there is increasing evidence that DMetD is…”
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A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves by Keijzer, Lana B. H., Caenen, Annette, Voorneveld, Jason, Strachinaru, Mihai, Bowen, Daniel J., van de Wouw, Jens, Sorop, Oana, Merkus, Daphne, Duncker, Dirk J., van der Steen, Antonius F. W., de Jong, Nico, Bosch, Johan G., Vos, Hendrik J.

“…Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve…”
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Early systemic microvascular damage in pigs with atherogenic diabetes mellitus coincides with renal angiopoietin dysbalance by Khairoun, Meriem, van den Heuvel, Mieke, van den Berg, Bernard M, Sorop, Oana, de Boer, Rients, van Ditzhuijzen, Nienke S, Bajema, Ingeborg M, Baelde, Hans J, Zandbergen, Malu, Duncker, Dirk J, Rabelink, Ton J, Reinders, Marlies E J, van der Giessen, Wim J, Rotmans, Joris I

“…Diabetes mellitus (DM) is associated with a range of microvascular complications including diabetic nephropathy (DN). Microvascular abnormalities in the…”
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Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine by van Ditzhuijzen, Nienke S, Kurata, Mie, van den Heuvel, Mieke, Sorop, Oana, van Duin, Richard W B, Krabbendam-Peters, Ilona, Ligthart, Jurgen, Witberg, Karen, Murawska, Magdalena, Bouma, Brett, Villiger, Martin, Garcia-Garcia, Hector M, Serruys, Patrick W, Zijlstra, Felix, van Soest, Gijs, Duncker, Dirk-Jan, Regar, Evelyn, van Beusekom, Heleen M M

“…DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS. The aim of our…”
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Small Artery Remodeling Depends on Tissue-Type Transglutaminase by Bakker, Erik N.T.P, Buus, Carsten L, Spaan, Jos A.E, Perree, Jop, Ganga, Anuradha, Rolf, Titia M, Sorop, Oana, Bramsen, Linda H, Mulvany, Michael J, VanBavel, Ed

“…Remodeling of small arteries is essential in the long-term regulation of blood pressure and blood flow to specific organs or tissues. A large part of the…”
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Lowering the Dose of Sirolimus, Released From a Nonpolymeric Hydroxyapatite Coated Coronary Stent, Reduces Signs of Delayed Healing by van der Giessen, Wim J., MD, PhD, Sorop, Oana, PhD, Serruys, Patrick W., MD, PhD, Peters-Krabbendam, Ilona, BSc, van Beusekom, Heleen M.M., PhD

“…Lowering the Dose of Sirolimus, Released From a Nonpolymeric Hydroxyapatite Coated Coronary Stent, Reduces Signs of Delayed Healing Wim J. van der Giessen,…”
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Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine by van Ditzhuijzen, Nienke S., MSc, van den Heuvel, Mieke, MD, Sorop, Oana, PhD, Rossi, Alexia, MD, PhD, Veldhof, Timothy, MSc, Bruining, Nico, PhD, Roest, Stefan, BSc, Ligthart, Jurgen M.R., RT, Witberg, Karen Th., CCRN, Dijkshoorn, Marcel L., BSc, Nieman, Koen, MD, PhD, Mulder, Monique T., PhD, Zijlstra, Felix, MD, PhD, Duncker, Dirk J., MD, PhD, van Beusekom, Heleen M.M., PhD, Regar, Evelyn, MD, PhD

“…Visual Abstract…”
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Endothelial function rather than endothelial restoration is altered in paclitaxel- as compared to bare metal-, sirolimusand tacrolimus-eluting stents by van Beusekom, Heleen, Sorop, Oana, van den Heuvel, Mieke, Onuma, Yoshinobu, Duncker, Dirk, Danser, A.H., van der Giessen, Willem

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Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction by Houweling, Birgit, Merkus, Daphne, Sorop, Oana, Boomsma, Frans, Duncker, Dirk J.

“…We previously observed that pulmonary hypertension secondary to myocardial infarction (MI) in swine is characterized by elevated plasma endothelin (ET) levels…”
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Myocardial epigenetic modifications link chronic kidney disease to coronary microvascular disease by Sen, Payel, Sorop, Oana, Merkus, Daphne

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Specific Coronary Drug-Eluting Stents Interfere With Distal Microvascular Function After Single Stent Implantation in Pigs by van den Heuvel, Mieke, MD, MSc, Sorop, Oana, PhD, Batenburg, Wendy W., PhD, Bakker, Charlotte L., BSc, de Vries, René, BSc, Koopmans, Sietse Jan, PhD, van Beusekom, Heleen M.M., PhD, Duncker, Dirk J., MD, PhD, Danser, A.H. Jan, PhD, van der Giessen, Willem J., MD, PhD

“…Objectives The aim of this study was to compare the effects of single drug-eluting stents (DES) on porcine coronary function distal to the stent in vivo and in…”
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