Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

Monocytes play a key role in the development of metabolic syndrome, and especially obesity. Given the complex features of their development from progenitor cells, whose regulation is mediated by their interactions with bone marrow adipocytes, the importance of a detailed study of the heterogeneous c...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 24; no. 15; p. 12259
Main Authors: Todosenko, Natalia, Khaziakhmatova, Olga, Malashchenko, Vladimir, Yurova, Kristina, Bograya, Maria, Beletskaya, Maria, Vulf, Maria, Mikhailova, Larisa, Minchenko, Anastasia, Soroko, Irina, Khlusov, Igor, Litvinova, Larisa
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 31-07-2023
MDPI
Subjects:
adipocyte
Adipocytes
Adipocytes - metabolism
Blood vessels
Body fat
Bone marrow
Chemokines
Development and progression
Health aspects
Homeostasis
Humans
Immune response
Inflammation
Inflammation - metabolism
Insulin resistance
Lipids
metabolic syndrome
Metabolic Syndrome - metabolism
Metabolism
monocytes
Monocytes - metabolism
Obesity
Obesity - metabolism
Physiological aspects
Review
Stem cells
Type 2 diabetes
metabolic syndrome
monocytes
inflammation
obesity
adipocyte
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Summary:Monocytes play a key role in the development of metabolic syndrome, and especially obesity. Given the complex features of their development from progenitor cells, whose regulation is mediated by their interactions with bone marrow adipocytes, the importance of a detailed study of the heterogeneous composition of monocytes at the molecular and systemic levels becomes clear. Research argues for monocytes as indicators of changes in the body's metabolism and the possibility of developing therapeutic strategies to combat obesity and components of metabolic syndrome based on manipulations of the monocyte compound of the immune response. An in-depth study of the heterogeneity of bone-marrow-derived monocytes and adipocytes could provide answers to many questions about the pathogenesis of obesity and reveal their therapeutic potential.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241512259