Search Results - "Sorokin, Lydia"

The impact of the extracellular matrix on inflammation by Sorokin, Lydia

“…The extracellular matrix (ECM) has crucial, though often overlooked, roles during the development of an inflammatory response. Lydia Sorokin describes the…”
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The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction by Engelhardt, Britta, Sorokin, Lydia

“…The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid (CSF)…”
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Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis by Agrawal, Smriti, Anderson, Per, Durbeej, Madeleine, van Rooijen, Nico, Ivars, Fredrik, Opdenakker, Ghislain, Sorokin, Lydia M

“…The endothelial cell monolayer of cerebral vessels and its basement membrane (BM) are ensheathed by the astrocyte endfeet, the leptomeningeal cells, and their…”
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Molecular characterization of perivascular drainage pathways in the murine brain by Hannocks, Melanie-Jane, Pizzo, Michelle E, Huppert, Jula, Deshpande, Tushar, Abbott, N Joan, Thorne, Robert G, Sorokin, Lydia

“…Perivascular compartments surrounding central nervous system (CNS) vessels have been proposed to serve key roles in facilitating cerebrospinal fluid flow into…”
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In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1β-induced peritonitis by Song, Jian, Wu, Chuan, Zhang, Xueli, Sorokin, Lydia M

“…Matrix metalloproteinases (MMPs) have been implicated in the cleavage of several proinflammatory chemokines, thereby modulating their function and having an…”
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Expression and Function of Laminins in the Embryonic and Mature Vasculature by Hallmann, Rupert, Horn, Nathalie, Selg, Manuel, Wendler, Olaf, Pausch, Friederike, Sorokin, Lydia M

“…Experimental Pathology, Lund University, Lund, Sweden; and Interdisciplinary Center for Clinical Research, University of Erlangen, Erlangen, Germany…”
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Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery by Pizzo, Michelle E., Wolak, Daniel J., Kumar, Niyanta N., Brunette, Eric, Brunnquell, Christina L., Hannocks, Melanie‐Jane, Abbott, N. Joan, Meyerand, M. Elizabeth, Sorokin, Lydia, Stanimirovic, Danica B., Thorne, Robert G.

“…Key points It is unclear precisely how macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) access brain tissue from the cerebrospinal…”
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Laminin isoforms in endothelial and perivascular basement membranes by Yousif, Lema F., Di Russo, Jacopo, Sorokin, Lydia

“…Laminins, one of the major functional components of basement membranes, are found underlying endothelium, and encasing pericytes and smooth muscle cells in the…”
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The regulation of immune cell trafficking by the extracellular matrix by Hallmann, Rupert, Zhang, Xueli, Di Russo, Jacopo, Li, Lixia, Song, Jian, Hannocks, Melanie-Jane, Sorokin, Lydia

“…The extracellular matrix (ECM) comes in different structural forms and biochemical compositions, which determine both its biophysical properties and its…”
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Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting by Liu, Jifeng, Long, Hongyan, Zeuschner, Dagmar, Räder, Andreas F. B., Polacheck, William J., Kessler, Horst, Sorokin, Lydia, Trappmann, Britta

“…A major deficit in tissue engineering strategies is the lack of materials that promote angiogenesis, wherein endothelial cells from the host vasculature invade…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration by Song, Jian, Wu, Chuan, Korpos, Eva, Zhang, Xueli, Agrawal, Smriti M., Wang, Ying, Faber, Cornelius, Schäfers, Michael, Körner, Heinrich, Opdenakker, Ghislain, Hallmann, Rupert, Sorokin, Lydia

“…Although chemokines are sufficient for chemotaxis of various cells, increasing evidence exists for their fine-tuning by selective proteolytic processing. Using…”
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Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity by Huang, Yin, Li, Qing, Zhang, Kunshan, Hu, Mingyuan, Wang, Yu, Du, Liming, Lin, Liangyu, Li, Siguang, Sorokin, Lydia, Melino, Gerry, Shi, Yufang, Wang, Ying

“…Mesenchymal stem cells (MSCs) are a population of multipotent cells with a superior ability to promote tissue repair by regulating regeneration and…”
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Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain by Jeong, Hyun-Woo, Diéguez-Hurtado, Rodrigo, Arf, Hendrik, Song, Jian, Park, Hongryeol, Kruse, Kai, Sorokin, Lydia, Adams, Ralf H

“…The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS)…”
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Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis by Bazigou, Eleni, Xie, Sherry, Chen, Chun, Weston, Anne, Miura, Naoyuki, Sorokin, Lydia, Adams, Ralf, Muro, Andrés F., Sheppard, Dean, Makinen, Taija

“…Dysfunction of lymphatic valves underlies human lymphedema, yet the process of valve morphogenesis is poorly understood. Here, we show that during…”
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Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration by Song, Jian, Zhang, Xueli, Buscher, Konrad, Wang, Ying, Wang, Huiyu, Di Russo, Jacopo, Li, Lixia, Lütke-Enking, Stefan, Zarbock, Alexander, Stadtmann, Anika, Striewski, Paul, Wirth, Benedikt, Kuzmanov, Ivan, Wiendl, Heinz, Schulte, Dörte, Vestweber, Dietmar, Sorokin, Lydia

“…Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte…”
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Multimodal Imaging Reveals Temporal and Spatial Microglia and Matrix Metalloproteinase Activity after Experimental Stroke by Zinnhardt, Bastian, Viel, Thomas, Wachsmuth, Lydia, Vrachimis, Alexis, Wagner, Stefan, Breyholz, Hans-Jörg, Faust, Andreas, Hermann, Sven, Kopka, Klaus, Faber, Cornelius, Dollé, Frédéric, Pappata, Sabina, Planas, Anna M, Tavitian, Bertrand, Schäfers, Michael, Sorokin, Lydia M, Kuhlmann, Michael T, Jacobs, Andreas H

“…Stroke is the most common cause of death and disability from neurologic disease in humans. Activation of microglia and matrix metalloproteinases (MMPs) is…”
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Endothelial basement membrane laminin 511 is essential for shear stress response by Di Russo, Jacopo, Luik, Anna‐Liisa, Yousif, Lema, Budny, Sigmund, Oberleithner, Hans, Hofschröer, Verena, Klingauf, Juergen, van Bavel, Ed, Bakker, Erik NTP, Hellstrand, Per, Bhattachariya, Anirban, Albinsson, Sebastian, Pincet, Frederic, Hallmann, Rupert, Sorokin, Lydia M

“…Shear detection and mechanotransduction by arterial endothelium requires junctional complexes containing PECAM‐1 and VE‐cadherin, as well as firm anchorage to…”
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Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis by Zhang, Xueli, Wu, Chuan, Song, Jian, Götte, Martin, Sorokin, Lydia

“…The cell surface heparan sulfate proteoglycan, syndecan-1, has been reported to be a negative regulator of various inflammatory processes, but its precise mode…”
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The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human by KORPOS, Eva, KADRI, Nadir, KAPPELHOFF, Reinhild, WEGNER, Jeannine, OVERALL, Christopher M, WEBER, Ekkehard, HOLMBERG, Dan, CARDELL, Susanna, SOROKIN, Lydia

“…We provide the first comprehensive analysis of the extracellular matrix (ECM) composition of peri-islet capsules, composed of the peri-islet basement membrane…”
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