Search Results - "Soroka, Joanna"

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones by Li, Jing, Soroka, Joanna, Buchner, Johannes

“…Hsp90 is a dimeric molecular chaperone required for the activation and stabilization of numerous client proteins many of which are involved in essential…”
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Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor by Shahid, Taha, Soroka, Joanna, Kong, Eric H, Malivert, Laurent, McIlwraith, Michael J, Pape, Tillmann, West, Stephen C, Zhang, Xiaodong

“…Structural and biochemical analyses of full-length human BRCA2 reveal how it facilitates RAD51-mediated homologous recombination to repair DNA double-strand…”
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Conserved Conformational Changes in the ATPase Cycle of Human Hsp90 by Richter, Klaus, Soroka, Joanna, Skalniak, Lukasz, Leskovar, Adriane, Hessling, Martin, Reinstein, Jochen, Buchner, Johannes

“…The dimeric molecular chaperone Hsp90 is required for the activation and stabilization of hundreds of substrate proteins, many of which participate in signal…”
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Mechanistic aspects of the Hsp90 phosphoregulation by Soroka, Joanna, Buchner, Johannes

“…Comment on: Soroka J, et al. Mol Cell 2012; 45:517-28…”
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Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation by Soroka, Joanna, Wandinger, Sebastian K., Mäusbacher, Nina, Schreiber, Thiemo, Richter, Klaus, Daub, Henrik, Buchner, Johannes

“…Hsp90 is an essential molecular chaperone in the eukaryotic cytosol. Its function is modulated by cochaperones and posttranslational modifications…”
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Unique Proline-Rich Domain Regulates the Chaperone Function of AIPL1 by Li, Jing, Zoldak, Gabriel, Kriehuber, Thomas, Soroka, Joanna, Schmid, Franz X, Richter, Klaus, Buchner, Johannes

“…Human aryl hydrocarbon receptor (AHR) interacting protein (AIP) and AIP like 1 (AIPL1) are cochaperones of Hsp90 which share 49% sequence identity. Both…”
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Global Analysis of Phosphoproteome Regulation by the Ser/Thr Phosphatase Ppt1 in Saccharomyces cerevisiae by Schreiber, Thiemo B, Mäusbacher, Nina, Soroka, Joanna, Wandinger, Sebastian K, Buchner, Johannes, Daub, Henrik

“…Even though protein phosphatases are key regulators of signal transduction, their cellular mechanisms of action are poorly understood. Here, we undertook a…”
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