Search Results - "Sorkness, R"

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma by KIAN FAN CHUNG, WENZEL, Sally E, BOULET, Louis-Philippe, BRIGHTLING, Christopher, CHANEZ, Pascal, DAHLEN, Sven-Erik, DJUKANOVIC, Ratko, FREY, Urs, GAGA, Mina, GIBSON, Peter, HAMID, Qutayba, JAJOUR, Nizar N, BROZEK, Jan L, MAUAD, Thais, SORKNESS, Ronald L, TEAGUE, W. Gerald, BUSH, Andrew, CASTRO, Mario, STERK, Peter J, ADCOCK, Ian M, BATEMAN, Eric D, BEL, Elisabeth H, BLEECKER, Eugene R

“…Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American…”
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Effects of viral respiratory infections on lung development and childhood asthma by Gern, James E., Rosenthal, Louis A., Sorkness, Ronald L., Lemanske, Robert F.

“…Viral infections are closely linked to wheezing in infancy, and those children with recurrent virus-induced wheezing episodes are at great risk for chronic…”
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Prevention of chronic postbronchiolitis airway sequelae with IFN-γ treatment in rats by SORKNESS, R. L, CASTLEMAN, W. L, KUMAR, A, KAPLAN, M. R, LEMANSKE, R. F

“…After viral bronchiolitis at an early age, Brown Norway (BN) rats develop chronic airway dysfunction consisting of inflammation, remodeling, episodic…”
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Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction by Mikus, L D, Rosenthal, L A, Sorkness, R L, Lemanske, Jr, R F

“…After parainfluenza type 1 (Sendai) virus infection as weanlings, Brown Norway (BN), unlike Fischer 344 (F344), rats develop an asthma-like phenotype. Reduced…”
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Chronic, episodic, reversible airway obstruction after viral bronchiolitis in rats by Kumar, A, Sorkness, R L, Kaplan, M R, Lemanske, Jr, R F

“…Viral bronchiolitis in human infants has been associated with persistent airway abnormalities, but not proven as a cause. Previously we observed some adult…”
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Attenuation of virus-induced airway dysfunction in rats treated with imiquimod by Stokes, , JR, Sorkness, RL, Kaplan, MR, Castleman, WL, Tomai, MA, Miller, RL, Lemanske RF, , Jr

“…Viral respiratory infections cause acute airway abnormalities consisting of inflammation and physiological dysfunction in both animals and humans. It is likely…”
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Altered Pulmonary Gene Expression in Response to Picornavirus-Induced Airway Infection in Mice by Rosenthal, L.A, Szakaly, R.J, Sorkness, R.L

“…Results In mice inoculated with active virus, as compared with those inoculated with vehicle or UV-inactivated virus, microarray analysis revealed marked…”
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Serial segmental bronchoalveolar lavage in individual rats by Varner, Arthur E, Sorkness, Ronald L, Kumar, Aparna, Kaplan, Michael R, Lemanske, Robert F., Jr

“…1  Division of Allergy and Immunology, Departments of Pediatrics and Medicine, and 2  School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53792…”
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Effect of ICAM-1 blockade on lung inflammation and physiology during acute viral bronchiolitis in rats by SORKNESS, R. L, MEHTA, H, KAPLAN, M. R, MIYASAKA, M, HEFLE, S. L, LEMANSKE, R. F

“…Viral respiratory infections cause acute bronchiolitis and physiologic dysfunction in human infants and in animals. It is possible that the pulmonary…”
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C26 ASTHMA IN INFANTS AND CHILDREN: Obstructive Phenotype As A Predictor Of Asthma Control And Stability In Children by Sorkness, R L, Zoratti, E, Kattan, M, Gergen, P J, Evans, M, Visness, C

“…The Composite Asthma Severity Index (CASI), the number of exacerbations, the standard deviation of FEV1 over 6 visits, and the methacholine PC20 during the…”
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Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness by Castleman, WL, Sorkness, RL, Lemanske, RF, Jr, McAllister, PK

“…The objectives of this study were to determine the kinetics of Sendai virus-induced increases in bronchiolar mast cells and to determine whether virus-induced…”
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C18 ADVANCES IN MEASURING LUNG FUNCTION: SMALL AIRWAYS AND UP: Age And Sex Influences On Dynamic Air-Trapping In Asthma by Sorkness, R, Kienert, C, O'Brien, M, Fain, S, Jarjour, N N

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D102 ADVANCES IN LUNG IMMUNOLOGY AND SARCOIDOSIS: Magnetic Resonance Image-Guided Bronchoscopic Sampling In Asthma Indicates Increased Levels Of Granulocytes In Areas Of Hyperpolarized 3he Ventilation Defect Compared With Control Sites by Mummy, D G, Sorkness, R L, Denlinger, L C, Jarjour, N N, Fain, S B

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C29 ADVANCES IN PULMONARY IMAGING TO STUDY LUNG STRUCTURE AND FUNCTION: Mri Measure Of Small Airways Dimensions In The Asthmatic Lung by Cadman, R V, Evans, M D, Sorkness, R L, Lemanske, R F, Jarjour, N N, Jackson, D J, Denlinger, L C, Fain, S B

“…Corresponding author's email: cadman@wisc.edu Rationale: A previous study [1] showed that in a cohort of children, asthma diagnosis was correlated with…”
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A35 SEVERE ASTHMA: Age Of Asthma Onset Differentiates Two Very Severe Asthma Phenotypes In The Severe Asthma Research Program by Moore, W C, Li, X, Li, H, Israel, E, Fitzpatrick, A M, Mauger, D, Phillips, B, Sorkness, R L, Wu, W, Wenzel, S E, Meyers, D, Bleecker, E

“…EOA3 had the most severe allergic asthma with poor baseline lung function and persistent airflow obstruction despite marked reversibility to albuterol (mean…”
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C97 CHARACTERIZING THE MANY FACES OF ASTHMA: Baseline Characteristics Associate With Persistent Asthma Severity At 1 And 2 Years Of Follow-Up In The Severe Asthma Research Program (sarp) by Wenzel, S E, Phillips, B, Gauthier, M, Bleecker, E R, Meyers, D A, Moore, W C, Israel, E, Fitzpatrick, A M, Sorkness, R L, Mauger, D

“…A univariable analysis was performed, applying logistic regression, to identify factors most strongly and independently associated with persistence versus…”
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A35 SEVERE ASTHMA: Differential Responses To Systemic Corticosteroids As Assessed By Cluster Analysis Of Data From The Severe Asthma Research Program (sarp) by Wu, W, Bleecker, E R, Meyers, D A, Moore, W C, Israel, E, Fitzpatrick, A, Sorkness, R L, Peters, M, Kerr, S, Hastie, A T, Wenzel, S E

“…Methods: 23 clinical, physiologic and inflammatory variables from 218 adult asthmatic subjects with paired (pre and 2-3 weeks post triamcinolone 40 mg IM)…”
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A98 SEEING IS BELIEVING: USING NOVEL IMAGING TECHNIQUES TO UNDERSTAND THE LUNG IN HEALTH AND DISEASE: Ventilation Defect Percent In Helium-3 Mri Is Associated With Severe Outcomes In Asthma by Mummy, D, Kruger, S, Evans, M D, Zha, W, Sorkness, R L, Jarjour, N N, Schiebler, M, Denlinger, L C, Fain, S B

“…Rationale: Hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) provides regional measurements of airway obstruction, potentially enhancing…”
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Simplified administration of aerosolized drugs to small animals using metered dose inhalers1 by SORKNESS, R

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B21 TRANSLATIONAL ASTHMA RESEARCH: Deltalumen In Asthma Patients By Computed Tomography: Correlation With Clinical Indices And Outcomes by Shim, S, Rodriguez, A, Schiebler, M L, Sorkness, R L, Jarjour, N N, Denlinger, L C, Fain, S B

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