Search Results - "Soriano, Aileen"

Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs) by Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J

“…Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases…”
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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants by SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Malignant bowel obstruction: individualized treatment near the end of life by Soriano, Aileen, Davis, Mellar P

“…Malignant bowel obstruction requires a highly individualized approach, tailored to the patient's medical condition, prognosis, and goals of care. Surgery…”
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Structural insights into selective small molecule activation of PKG1α by Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J., Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C., Greshock, Tom, Fischmann, Thierry O.

“…cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While…”
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GTP-Dependent Activation of Urease Apoprotein in Complex with the UreD, UreF, and UreG Accessory Proteins by Soriano, A, Hausinger, R P

“…Syntheses of metal-containing enzymes often require the participation of accessory proteins. The roles played by many of these accessory proteins are poorly…”
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Exploring The Level of Student Teaching Performance of The Pre-Service Teachers by Soriano, Aileen

“…Knowledge, competences, and attitudes are the three most important factors that contribute to one's level of success in the teaching profession. The…”
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Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum by HEGDE, Vinod R, HAIYAN PU, PATEL, Mahesh, BLACK, Todd, SORIANO, Aileen, WENJUN ZHAO, GULLO, Vincent P, CHAN, Tze-Ming

“…The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were…”
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Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α by Tawa, Paul, Zhang, Lei, Metwally, Essam, Hou, Yan, McCoy, Mark A., Seganish, W. Michael, Zhang, Rumin, Frank, Emily, Sheth, Payal, Hanisak, Jennifer, Sondey, Christopher, Bauman, David, Soriano, Aileen

“…cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP…”
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Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α by Mak, Victor W., Patel, Akash M., Yen, Rose, Hanisak, Jennifer, Lim, Yeon-Hee, Bao, Jianming, Zheng, Rong, Seganish, W. Michael, Yu, Yang, Healy, David R., Ogawa, Aimie, Ren, Zhao, Soriano, Aileen, Ermakov, Grigori P., Beaumont, Maribel, Metwally, Essam, Cheng, Alan C., Verras, Andreas, Fischmann, Thierry, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Barker, John, Rearden, Paul, Greshock, Thomas J.

“…Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP),…”
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Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α) by Hanisak, Jennifer, Soriano, Aileen, Adam, Gregory C, Basso, Andrea, Bauman, David, Bell, David, Frank, Emily, O’Donnell, Gregory, Tawa, Paul, Verras, Andreas, Yu, Yang, Zhang, Lei, Seganish, W. Michael

“…PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation…”
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Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor by Walker, Scott S, Degen, David, Nickbarg, Elliott, Carr, Donna, Soriano, Aileen, Mandal, Mihir, Painter, Ronald E, Sheth, Payal, Xiao, Li, Sher, Xinwei, Murgolo, Nicholas, Su, Jing, Olsen, David B, Ebright, Richard H, Young, Katherine

“…The growing prevalence of drug resistant bacteria is a significant global threat to human health. The antibacterial drug rifampin, which functions by…”
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Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors by Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W

“…A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic proline–P2 surrogate onto the P2–P4 macrocyclic core of MK-5172…”
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Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes by Wu, Wen-Lian, Hao, Jinsong, Domalski, Martin, Burnett, Duane A, Pissarnitski, Dmitri, Zhao, Zhiqiang, Stamford, Andrew, Scapin, Giovanna, Gao, Ying-Duo, Soriano, Aileen, Kelly, Terri M, Yao, Zuliang, Powles, Mary Ann, Chen, Shiying, Mei, Hong, Hwa, Joyce

“…In our efforts to develop second generation DPP-4 inhibitors, we endeavored to identify distinct structures with long-acting (once weekly) potential. Taking…”
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Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors by Pissarnitski, Dmitri A., Zhao, Zhiqiang, Cole, David, Wu, Wen-Lian, Domalski, Martin, Clader, John W., Scapin, Giovanna, Voigt, Johannes, Soriano, Aileen, Kelly, Theresa, Powles, Mary Ann, Yao, Zuliang, Burnett, Duane A.

“…[Display omitted] Molecular modeling of unbound tricyclic guanine scaffolds indicated that they can serve as effective bioisosteric replacements of xanthines…”
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IC‐P‐199: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) In In vitro Binding Studies in Brain Tissues by Zeng, Zhizhen, Miller, Patricia J., Connolly, Brett M., O’Malley, Stacey S., Bennacef, Idriss, Mulhearn, James, Schenk, David J., Hesk, David, Soriano, Aileen, Abbas, Walji, Hostetler, Eric D.

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P1‐244: Comparing [3H]MK‐6240 and [3H]AV‐1451(T‐807) in in VITRO Binding Studies in Brain Tissues by Zeng, Zhizhen, Miller, Patricia J., Connolly, Brett M., O’Malley, Stacey S., Bennacef, Idriss, Mulhearn, James, David, Schenk J., Hesk, David, Soriano, Aileen, Abbas, Walji, Eric, Hostetler D.

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Preclinical Characterization of super( 18)F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles by Hostetler, Eric D, Walji, Abbas M, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Haley, Hyking, Holahan, Marie, Purcell, Mona, Riffel, Kerry, Lohith, Talakad G, Coleman, Paul, Soriano, Aileen, Ogawa, Aimie, Xu, Serena, Zhang, Xiaoping, Joshi, Elizabeth, Della Rocca, Joseph, Hesk, David, Schenk, David J, Evelhoch, Jeffrey L

“…A PET tracer is desired to help guide the discovery and development of disease-modifying therapeutics for neurodegenerative diseases characterized by…”
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Preclinical Characterization of 18 F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles by Hostetler, Eric D., Walji, Abbas M., Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Haley, Hyking, Holahan, Marie, Purcell, Mona, Riffel, Kerry, Lohith, Talakad G., Coleman, Paul, Soriano, Aileen, Ogawa, Aimie, Xu, Serena, Zhang, Xiaoping, Joshi, Elizabeth, Della Rocca, Joseph, Hesk, David, Schenk, David J., Evelhoch, Jeffrey L.

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Preclinical Characterization of ^sup 18^F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles by Hostetler, Eric D, Walji, Abbas M, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Haley, Hyking, Holahan, Marie, Purcell, Mona, Riffel, Kerry, Lohith, Talakad G, Coleman, Paul, Soriano, Aileen, Ogawa, Aimie, Xu, Serena, Zhang, Xiaoping, Joshi, Elizabeth, Della Rocca, Joseph, Hesk, David, Schenk, David J, Evelhoch, Jeffrey L

“…A PET tracer is desired to help guide the discovery and development of disease-modifying therapeutics for neurodegenerative diseases characterized by…”
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Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor by Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth

“…We have been focused on identifying a structurally different next generation inhibitor to MK-5172 (our Ns3/4a protease inhibitor currently under regulatory…”
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