Search Results - "Sorets, Alex G."

Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing by Patel, Shrusti S., Hoogenboezem, Ella N., Yu, Fang, DeJulius, Carlisle R., Fletcher, R. Brock, Sorets, Alex G., Cherry, Fiona K., Lo, Justin H., Bezold, Mariah G., Francini, Nora, d’Arcy, Richard, Brasuell, Jordan E., Cook, Rebecca S., Duvall, Craig L.

“…Gene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized for inhibition of tumor driver genes. Ternary si-NPs containing…”
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Abstract 2706: Therapeutic silencing of Rictor using siRNA nanoparticles to selectively block mTORC2 signaling in triple negative breast cancer by Patel, Shrusti S., Hoogenboezem, Ella N., Yu, Fang, Sorets, Alex G., Cherry, Fiona K., Lo, Justin H., Francini, Nora, d'Arcy, Richard A., Cook, Rebecca S., Duvall, Craig L.

“…Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection…”
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