Search Results - "Sorensen, Poul"

Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers by Heravi-Moussavi, Alireza, Anglesio, Michael S, Cheng, S.-W. Grace, Senz, Janine, Yang, Winnie, Prentice, Leah, Fejes, Anthony P, Chow, Christine, Tone, Alicia, Kalloger, Steve E, Hamel, Nancy, Roth, Andrew, Ha, Gavin, Wan, Adrian N.C, Maines-Bandiera, Sarah, Salamanca, Clara, Pasini, Barbara, Clarke, Blaise A, Lee, Cheng-Han, Lee, Anna F, Zhao, Chengquan, Young, Robert H, Aparicio, Samuel A, Sorensen, Poul H.B, Woo, Michelle M.M, Boyd, Niki, Jones, Steven J.M, Hirst, Martin, Marra, Marco A, Gilks, Blake, Shah, Sohrab P, Foulkes, William D, Morin, Gregg B, Huntsman, David G

“…Primitive cancers have so-called hot-spot mutations in DICER1 that alter the function of DICER1, an enzyme that processes microRNA. Some of these cancers…”
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Single-pot, solid-phase-enhanced sample preparation for proteomics experiments by Hughes, Christopher S., Moggridge, Sophie, Müller, Torsten, Sorensen, Poul H., Morin, Gregg B., Krijgsveld, Jeroen

“…A critical step in proteomics analysis is the optimal extraction and processing of protein material to ensure the highest sensitivity in downstream detection…”
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CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors by Majzner, Robbie G, Theruvath, Johanna L, Nellan, Anandani, Heitzeneder, Sabine, Cui, Yongzhi, Mount, Christopher W, Rietberg, Skyler P, Linde, Miles H, Xu, Peng, Rota, Christopher, Sotillo, Elena, Labanieh, Louai, Lee, Daniel W, Orentas, Rimas J, Dimitrov, Dimiter S, Zhu, Zhongyu, Croix, Brad St, Delaidelli, Alberto, Sekunova, Alla, Bonvini, Ezio, Mitra, Siddhartha S, Quezado, Martha M, Majeti, Ravindra, Monje, Michelle, Sorensen, Poul H B, Maris, John M, Mackall, Crystal L

“…Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor…”
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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA by Kapranov, Philipp, St Laurent, Georges, Raz, Tal, Ozsolak, Fatih, Reynolds, C Patrick, Sorensen, Poul H B, Reaman, Gregory, Milos, Patrice, Arceci, Robert J, Thompson, John F, Triche, Timothy J

“…Discovery that the transcriptional output of the human genome is far more complex than predicted by the current set of protein-coding annotations and that most…”
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Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics by Moggridge, Sophie, Sorensen, Poul H, Morin, Gregg B, Hughes, Christopher S

“…The diversity in protein and peptide biochemistry necessitates robust protocols and reagents for efficiently handling and enriching these molecules prior to…”
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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance by Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.

“…The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying…”
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Simulation of transcontinental wind and solar PV generation time series by Nuño, Edgar, Maule, Petr, Hahmann, Andrea, Cutululis, Nicolaos, Sørensen, Poul, Karagali, Ioanna

“…The deployment of Renewable Energy Sources (RES) is driving modern power systems towards a fundamental green transition. In this regard, there is a need to…”
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Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma by KHANNA, Chand, FAN, Timothy M, MERLINO, Glenn, SORENSEN, Poul H. B, MELTZER, Paul, KIRSCH, David G, JANEWAY, Katherine A, WEIGEL, Brenda, RANDALL, Lor, WITHROW, Stephen J, PAOLONI, Melissa, KAPLAN, Rosandra, GORLICK, Richard, TEICHER, Beverly A, SEIBEL, Nita L, SMITH, Malcolm, UREN, Aykut, PATEL, Shreyaskumar R, TRENT, Jeffrey, SAVAGE, Sharon A, MIRABELLO, Lisa, REINKE, Denise, BARKAUKAS, Donald A, HELMAN, Lee J, KRAILO, Mark, BERNSTEIN, Mark, KLEINERMAN, Eugenie S, ADAMSON, Peter C, HOUGHTON, Peter J, TAP, William D, WELCH, Danny R, STEEG, Patricia S

“…Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with…”
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Releasable Kinetic Energy-Based Inertial Control of a DFIG Wind Power Plant by Lee, Jinsik, Muljadi, Eduard, Sorensen, Poul, Kang, Yong Cheol

“…Wind turbine generators (WTGs) in a wind power plant (WPP) contain different levels of releasable kinetic energy (KE) because of the wake effects. This paper…”
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Molecular Classification of Rhabdomyosarcoma--Genotypic and Phenotypic Determinants of Diagnosis: A Report from the Children's Oncology Group by Davicioni, Elai, Anderson, Michael J, Finckenstein, Friedrich Graf, Lynch, James C, Qualman, Stephen J, Shimada, Hiroyuki, Schofield, Deborah E, Buckley, Jonathan D, Meyer, William H, Sorensen, Poul H.B, Triche, Timothy J

“…Rhabdomyosarcoma (RMS) in children occurs as two major histological subtypes, embryonal (ERMS) and alveolar (ARMS). ERMS is associated with an 11p15.5 loss of…”
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Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer by Wong, Derek, Yip, Stephen, Sorensen, Poul H.

“…NTRK gene fusions affecting the tropomyosin receptor kinase (TRK) protein family have been found to be oncogenic drivers in a broad range of cancers. Small…”
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Regulation of AR mRNA translation in response to acute AR pathway inhibition by Somasekharan, Syam Prakash, Saxena, Neetu, Zhang, Fan, Beraldi, Eliana, Huang, Jia Ni, Gentle, Christina, Fazli, Ladan, Thi, Marisa, Sorensen, Poul H, Gleave, Martin

“…Abstract We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection in response to AR pathway inhibition (ARPI) stress in prostate…”
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Translational control of aberrant stress responses as a hallmark of cancer by El‐Naggar, Amal M, Sorensen, Poul H

“…Altered mRNA translational control is emerging as a critical factor in cancer development and progression. Targeting specific elements of the translational…”
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Transsulfuration, minor player or crucial for cysteine homeostasis in cancer by Zhang, Hai-Feng, Klein Geltink, Ramon I., Parker, Seth J., Sorensen, Poul H.

“…Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing biomolecules that control multiple essential cellular activities…”
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G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress by Somasekharan, Syam Prakash, Zhang, Fan, Saxena, Neetu, Huang, Jia Ni, Kuo, I-Chih, Low, Caitlin, Bell, Robert, Adomat, Hans, Stoynov, Nikolay, Foster, Leonard, Gleave, Martin, Sorensen, Poul H

“…Abstract Cells limit energy-consuming mRNA translation during stress to maintain metabolic homeostasis. Sequestration of mRNAs by RNA binding proteins (RBPs)…”
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Actions speak louder than ORFs: A non-canonical microprotein promotes medulloblastoma oncogenesis by Delaidelli, Alberto, Oliveira de Santis, Jessica, Sorensen, Poul H

“…In this issue of Molecular Cell, Hofman et al. identify the translation of a non-canonical upstream open reading frame of the ASNSD1 gene into a microprotein…”
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Stress-mediated translational control in cancer cells by Leprivier, Gabriel, Rotblat, Barak, Khan, Debjit, Jan, Eric, Sorensen, Poul H.

“…Tumor cells are continually subjected to diverse stress conditions of the tumor microenvironment, including hypoxia, nutrient deprivation, and oxidative or…”
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E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase by KANG, Hyung-Gyoo, JENABI, Jasmine M, JINGSONG ZHANG, KESHELAVA, Nino, SHIMADA, Hiroyuki, MAY, William A, NG, Tony, REYNOLDS, C. Patrick, TRICHE, Timothy J, SORENSEN, Poul H. B

“…Ability to grow under anchorage-independent conditions is one of the major hallmarks of transformed cells. Key to this is the capacity of cells to suppress…”
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Validation of European-scale simulated wind speed and wind generation time series by Murcia, Juan Pablo, Koivisto, Matti Juhani, Luzia, Graziela, Olsen, Bjarke T., Hahmann, Andrea N., Sørensen, Poul Ejnar, Als, Magnus

“…This paper presents a validation of atmospheric reanalysis data sets for simulating onshore wind generation time series for large-scale energy system studies…”
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YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1 by Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G P, Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H

“…Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes…”
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