Fish intake is associated with lower cardiovascular risk in a Mediterranean population: Prospective results from the Moli-sani study

Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) a...

Full description

Saved in:

Bibliographic Details
Published in:	Nutrition, metabolism, and cardiovascular diseases Vol. 27; no. 10; pp. 865 - 873
Main Authors:	Bonaccio, M., Ruggiero, E., Di Castelnuovo, A., Costanzo, S., Persichillo, M., De Curtis, A., Cerletti, C., Donati, M.B., de Gaetano, G., Iacoviello, L., Vermylen, J., De Paula Carrasco, I., Giampaoli, S., Spagnuolo, A., Assanelli, D., Centritto, V., Spagnuolo, P., Staniscia, D., Zito, F., Bonanni, A., Lorenzet, R., Mascioli, A., Olivieri, M., Rotilio, D., Gianfagna, F., Giacci, M., Padulo, A., Petraroia, D., Magnacca, S., Marracino, F., Spinelli, M., Silvestri, C., dell’Elba, G., Grippi, C., De Lucia, F., Vohnout, B., Verna, A., Di Lillo, M., Di Stefano, I., Pampuch, A., Pannichella, A., Vizzarri, A.R., Arcari, A., Barbato, D., Bracone, F., Di Giorgio, C., Panebianco, S., Chiovitti, A., Caccamo, S., Caruso, V., Rago, L., Cugino, D., Ferri, A., Castaldi, C., Mignogna, M., Guszcz, T., di Giuseppe, R., Barisciano, P., Buonaccorsi, L., Centritto, F., Cutrone, A., Fanelli, F., Santimone, I., Sciarretta, A., Sorella, I., Plescia, E., Molinaro, A., Cavone, C., Galuppo, G., D'Angelo, D., Ramacciato, R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-10-2017
Subjects:	Adult Aged Animals Cardiovascular risk Cerebrovascular events Coronary Disease - diagnosis Coronary Disease - epidemiology Coronary Disease - prevention & control Coronary heart disease Diet, Mediterranean Dietary Fats - administration & dosage Fatty fish Feeding Behavior Female Fish intake Fishes Healthy Diet Humans Italy - epidemiology Male Middle Aged Multivariate Analysis Proportional Hazards Models Prospective Studies Protective Factors Risk Factors Seafood Stroke Stroke - diagnosis Stroke - epidemiology Stroke - prevention & control Time Factors Fatty fish Stroke Cerebrovascular events Fish intake Coronary heart disease Cardiovascular risk
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005–2010). Food intake was recorded by the Italian version of the EPIC food frequency questionnaire. Hazard ratios were calculated by using multivariable Cox-proportional hazard models. During a median follow-up of 4.3 years, a total of 352 events occurred (n of CHD = 287 and n of stroke = 66). After adjustment for a large panel of covariates, fish intake ≥4 times per week was associated with 40% reduced risk of composite CHD and stroke (HR = 0.60; 95%CI 0.40–0.90), and with 40% lower risk of CHD (HR = 0.60; 95%CI 0.38–0.94) as compared with subjects in the lowest category of intake (<2 times/week). A similar trend of protection was found for stroke risk although results were not significant (HR = 0.62; 95%CI 0.26–1.51). When fish types were considered, protection against the composite outcome and CHD was confined to fatty fish intake. Fish intake was associated with reduced risk of composite fatal and non-fatal CHD and stroke in a general Mediterranean population. The favourable association was likely to be driven by fatty fish. •High fish intake is associated with lower risk of cardiovascular disease (CVD).•CVD advantages are confirmed in a Mediterranean population.•This study confirms a predominant protective role of fatty over lean fish intake.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0939-4753 1590-3729
DOI:	10.1016/j.numecd.2017.08.004