Search Results - "Sorcini, Daniele"

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis by Biagioli, Michele, Carino, Adriana, Cipriani, Sabrina, Francisci, Daniela, Marchianò, Silvia, Scarpelli, Paolo, Sorcini, Daniele, Zampella, Angela, Fiorucci, Stefano

“…GPBAR1 (TGR5 or M-BAR) is a G protein-coupled receptor for secondary bile acids that is highly expressed in monocytes/macrophages. In this study, we aimed to…”
Get full text

Mutant NPM1 Maintains the Leukemic State through HOX Expression by Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.

“…NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia (AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic…”
Get full text

Nanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies by Adamo, Francesco Maria, De Falco, Filomena, Dorillo, Erica, Sorcini, Daniele, Stella, Arianna, Esposito, Angela, Arcaleni, Roberta, Rosati, Emanuela, Sportoletti, Paolo

“…Lymphoid malignancies are complex diseases with distinct biological behaviors, clinical presentations, and treatment responses. Ongoing research and…”
Get full text

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice by Sportoletti, Paolo, Sorcini, Daniele, Guzman, Anna G., Reyes, Jaime M., Stella, Arianna, Marra, Andrea, Sartori, Sara, Brunetti, Lorenzo, Rossi, Roberta, Papa, Beatrice Del, Adamo, Francesco Maria, Pianigiani, Giulia, Betti, Camilla, Scialdone, Annarita, Guarente, Valerio, Spinozzi, Giulio, Tini, Valentina, Martelli, Maria Paola, Goodell, Margaret A., Falini, Brunangelo

“…Recurrent loss-of-function mutations of BCL6 co-repressor ( BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with…”
Get full text

GILZ Promotes Production of Peripherally Induced Treg Cells and Mediates the Crosstalk between Glucocorticoids and TGF-β Signaling by Bereshchenko, Oxana, Coppo, Maddalena, Bruscoli, Stefano, Biagioli, Michele, Cimino, Monica, Frammartino, Tiziana, Sorcini, Daniele, Venanzi, Alessandra, Di Sante, Moises, Riccardi, Carlo

“…Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (FoxP3) control immune responses and prevent autoimmunity. Treatment with…”
Get full text

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations by Sportoletti, Paolo, Celani, Letizia, Varasano, Emanuela, Rossi, Roberta, Sorcini, Daniele, Rompietti, Chiara, Strozzini, Francesca, Del Papa, Beatrice, Guarente, Valerio, Spinozzi, Giulio, Cecchini, Debora, Bereshchenko, Oxana, Haferlach, Torsten, Martelli, Maria Paola, Falzetti, Franca, Falini, Brunangelo

Get full text

Glucocorticoid-Induced Leucine Zipper Inhibits Interferon-Gamma Production in B Cells and Suppresses Colitis in Mice by Bruscoli, Stefano, Sorcini, Daniele, Flamini, Sara, Gagliardi, Andrea, Adamo, Francesco, Ronchetti, Simona, Migliorati, Graziella, Bereshchenko, Oxana, Riccardi, Carlo

“…Glucocorticoid-induced leucine zipper (GILZ) is transcriptionally upregulated by glucocorticoids (GCs) and mediates many of the anti-inflammatory effects of…”
Get full text

Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice by Sorcini, Daniele, Bruscoli, Stefano, Frammartino, Tiziana, Cimino, Monica, Mazzon, Emanuela, Galuppo, Maria, Bramanti, Placido, Al-Banchaabouchi, Mumna, Farley, Dominika, Ermakova, Olga, Britanova, Olga, Izraelson, Mark, Chudakov, Dmitry, Biagioli, Michele, Sportoletti, Paolo, Flamini, Sara, Raspa, Marcello, Scavizzi, Ferdinando, Nerlov, Claus, Migliorati, Graziella, Riccardi, Carlo, Bereshchenko, Oxana

“…The mechanisms leading to autoimmune and inflammatory diseases in the CNS have not been elucidated. The environmental triggers of the aberrant presence of CD4…”
Get full text

NOTCH1 inhibition prevents GvHD and maintains GvL effect in murine models by Baldoni, Stefano, Ruggeri, Loredana, Del Papa, Beatrice, Sorcini, Daniele, Guardalupi, Francesco, Ulbar, Francesca, Marra, Andrea, Dorillo, Erica, Stella, Arianna, Giancola, Raffaella, Fabi, Bianca, Sola, Rosaria, Ciardelli, Sara, De Falco, Filomena, Rompietti, Chiara, Adamo, Francesco Maria, Rosati, Emanuela, Pierini, Antonio, Sorrentino, Carlo, Sportoletti, Paolo, Di Ianni, Mauro

Get full text

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL by De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Esposito, Angela, Scialdone, Annarita, Baldoni, Stefano, Del Papa, Beatrice, Adamo, Francesco Maria, Silva Barcelos, Estevão Carlos, Dorillo, Erica, Stella, Arianna, Di Ianni, Mauro, Screpanti, Isabella, Sportoletti, Paolo, Rosati, Emanuela

“…NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL cells are not…”
Get full text

NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential by Silva Barcelos, Estevão Carlos, Rompietti, Chiara, Adamo, Francesco Maria, Dorillo, Erica, De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Nogarotto, Manuel, Esposito, Angela, Capoccia, Silvia, Geraci, Clelia, Sorcini, Daniele, Stella, Arianna, Arcaleni, Roberta, Tini, Valentina, Imbroisi Valle Errera, Flávia, Rosati, Emanuela, Sportoletti, Paolo

“…Introduction Constitutive activation of NOTCH1 -wild-type (NT1-WT) signaling is associated with poor outcomes in chronic lymphocytic leukemia (CLL), and NOTCH1…”
Get full text

Case Report: Contrasting BCL2 Upregulation With Venetoclax in a Case of Refractory Lymphomatoid Papulosis and Progressive Chronic Lymphocytic Leukemia by Guarente, Valerio, Martino, Giovanni, Dorillo, Erica, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Brogna, Mariangela, Cardinali, Valeria, Ascani, Stefano, Marra, Andrea, Sportoletti, Paolo

“…A 57-year-old man affected by high-risk progressive chronic lymphocytic leukemia (CLL), primary resistant to first-line chemoimmunotherapy, developed a type A…”
Get full text

PB1762: A NEW MONOCLONAL ANTIBODY PROVIDES INSIGHTS ON NPM1 MUTANT SUBCELLULAR EXPRESSION, INTRACLONAL CELL DIFFERENTIATION AND MRD IN NPM1‐MUTATED AML by Falini, Brunangelo, Martelli, Maria Paola, Rossi, Riccardo, Facchetti, Fabio, Zini, Stefania, Borlenghi, Erica, Sabbatini, Elena, Brunetti, Lorenzo, Sorcini, Daniele, Perriello, Vincenzo, Tiacci, Enrico, Gjertsen, Bjorn, Andresen, Vibeke

Get full text

Polatuzumab‐bendamustine‐rituximab as bridge to CD19‐directed CAR T cells in mantle cell lymphoma refractory to ibrutinib and venetoclax by Perriello, Vincenzo Maria, Falini, Lorenza, Ruggeri, Loredana, Sorcini, Daniele, Ballanti, Stelvio, Flenghi, Leonardo, Baffa, Nicodemo, Covarelli, Piero, Sportoletti, Paolo, Pierini, Antonio, Falini, Brunangelo

“…Here, we report a 47-year-old man with pleomorphic cMCL carrying a TP53 mutation that, due to chemotherapy resistance and high tumour burden disease, was…”
Get full text

NOTCH1 Activation Negatively Impacts on Chronic Lymphocytic Leukemia Outcome and Is Not Correlated to the NOTCH1 and IGHV Mutational Status by Baldoni, Stefano, Del Papa, Beatrice, De Falco, Filomena, Dorillo, Erica, Sorrentino, Carlo, Rompietti, Chiara, Adamo, Francesco Maria, Nogarotto, Manuel, Cecchini, Debora, Mondani, Elena, Silva Barcelos, Estevao Carlos, Moretti, Lorenzo, Mameli, Maria Grazia, Fabi, Bianca, Sorcini, Daniele, Stella, Arianna, Giancola, Raffaella, Guardalupi, Francesco, Ulbar, Francesca, Plebani, Sara, Guarente, Valerio, Rosati, Emanuela, Di Nicola, Marta, Marchioni, Michele, Di Ianni, Mauro, Sportoletti, Paolo

“…NOTCH1 mutations and deregulated signal have been commonly found in chronic lymphocytic leukemia (CLL) patients. Whereas the impact of NOTCH1 mutations on…”
Get full text

BCOR gene alterations in hematologic diseases by Sportoletti, Paolo, Sorcini, Daniele, Falini, Brunangelo

“…The BCL6 corepressor (BCOR) is a transcription factor involved in the control of embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid…”
Get full text

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice by Bruscoli, Stefano, Biagioli, Michele, Sorcini, Daniele, Frammartino, Tiziana, Cimino, Monica, Sportoletti, Paolo, Mazzon, Emanuela, Bereshchenko, Oxana, Riccardi, Carlo

“…Glucocorticoids (GC) are widely used as antiinflammatory/immunosuppressive drugs and antitumor agents in several types of lymphoma and leukemia. Therapeutic…”
Get full text

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein by Pianigiani, Giulia, Rocchio, Francesca, Peruzzi, Sara, Andresen, Vibeke, Bigerna, Barbara, Sorcini, Daniele, Capurro, Michela, Gjertsen, Bjørn Tore, Sportoletti, Paolo, Di Ianni, Mauro, Martelli, Maria Paola, Brunetti, Lorenzo, Falini, Brunangelo

Get full text

Immune correlates of protection by vaccine against SARS‐CoV‐2 in patients with chronic lymphocytic leukaemia by Sorcini, Daniele, De Falco, Filomena, Gargaro, Marco, Bozza, Silvia, Guarente, Valerio, Cardinali, Valeria, Stella, Arianna, Adamo, Francesco Maria, Silva Barcelos, Estevao Carlos, Rompietti, Chiara, Dorillo, Erica, Geraci, Clelia, Esposito, Angela, Arcaleni, Roberta, Capoccia, Silvia, Mameli, Maria Grazia, Graziani, Alessandro, Moretti, Lorenzo, Cipiciani, Alessandra, Riccardi, Carlo, Mencacci, Antonella, Fallarino, Francesca, Rosati, Emanuela, Sportoletti, Paolo

“…Summary In chronic lymphocytic leukaemia (CLL) the efficacy of SARS‐CoV‐2 vaccination remains unclear as most studies have focused on humoral responses. Here…”
Get full text

Bepridil exhibits anti‐leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia by Baldoni, Stefano, Del Papa, Beatrice, Dorillo, Erica, Aureli, Patrizia, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Varasano, Emanuela, Cecchini, Debora, Zei, Tiziana, Di Tommaso, Ambra, Rosati, Emanuela, Alexe, Gabriela, Roti, Giovanni, Stegmaier, Kimberly, Di Ianni, Mauro, Falzetti, Franca, Sportoletti, Paolo

“…Dysregulated NOTCH1 signaling, by either gene mutations or microenvironment interactions, has been increasingly linked to chronic lymphocytic leukemia (CLL)…”
Get full text