Search Results - "Sorace, Anna"

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system by Zhang, Jialing, Rector, John, Lin, John Q, Young, Jonathan H, Sans, Marta, Katta, Nitesh, Giese, Noah, Yu, Wendong, Nagi, Chandandeep, Suliburk, James, Liu, Jinsong, Bensussan, Alena, DeHoog, Rachel J, Garza, Kyana Y, Ludolph, Benjamin, Sorace, Anna G, Syed, Anum, Zahedivash, Aydin, Milner, Thomas E, Eberlin, Livia S

“…Conventional methods for histopathologic tissue diagnosis are labor- and time-intensive and can delay decision-making during diagnostic and therapeutic…”
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18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition by Reeves, Kirsten M., Song, Patrick N., Angermeier, Allyson, Manna, Deborah Della, Li, Yufeng, Wang, Jianbo, Yang, Eddy S., Sorace, Anna G., Larimer, Benjamin M.

“…PURPOSEHypoxia is a common characteristic of many tumor microenvironments, and it has been shown to promote suppression of antitumor immunity. Despite strong…”
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Microbubble-mediated ultrasonic techniques for improved chemotherapeutic delivery in cancer by Sorace, Anna G., Warram, Jason M., Umphrey, Heidi, Hoyt, Kenneth

“…Background: Ultrasound (US) exposed microbubble (MB) contrast agents have the capability to transiently enhance cell membrane permeability. Using this…”
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Antibody-based imaging strategies for cancer by Warram, Jason M., de Boer, Esther, Sorace, Anna G., Chung, Thomas K., Kim, Hyunki, Pleijhuis, Rick G., van Dam, Gooitzen M., Rosenthal, Eben L.

“…Although mainly developed for preclinical research and therapeutic use, antibodies have high antigen specificity, which can be used as a courier to selectively…”
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Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+ breast cancer by Jarrett, Angela M., Shah, Alay, Bloom, Meghan J., McKenna, Matthew T., Hormuth, David A., Yankeelov, Thomas E., Sorace, Anna G.

“…The goal of this study is to experimentally and computationally investigate combination trastuzumab-paclitaxel therapies and identify potential synergistic…”
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Evaluating patient-specific neoadjuvant regimens for breast cancer via a mathematical model constrained by quantitative magnetic resonance imaging data by Jarrett, Angela M., Hormuth, David A., Wu, Chengyue, Kazerouni, Anum S., Ekrut, David A., Virostko, John, Sorace, Anna G., DiCarlo, Julie C., Kowalski, Jeanne, Patt, Debra, Goodgame, Boone, Avery, Sarah, Yankeelov, Thomas E.

“…The ability to accurately predict response and then rigorously optimize a therapeutic regimen on a patient-specific basis, would transform oncology. Toward…”
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RORγt-Expressing Pathogenic CD4 + T Cells Cause Brain Inflammation during Chronic Colitis by Mickael, Michel Edwar, Bhaumik, Suniti, Chakraborti, Ayanabha, Umfress, Alan A, van Groen, Thomas, Macaluso, Matthew, Totenhagen, John, Sorace, Anna G, Bibb, James A, Standaert, David G, Basu, Rajatava

“…Neurobehavioral disorders and brain abnormalities have been extensively reported in both Crohn's disease and ulcerative colitis patients. However, the…”
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Optimizing combination therapy in a murine model of HER2+ breast cancer by Lima, Ernesto A.B.F., Wyde, Reid A.F., Sorace, Anna G., Yankeelov, Thomas E.

“…Human epidermal growth factor receptor 2 positive (HER2+) breast cancer is frequently treated with drugs that target the HER2 receptor, such as trastuzumab, in…”
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Characterizing Trastuzumab-Induced Alterations in Intratumoral Heterogeneity with Quantitative Imaging and Immunohistochemistry in HER2+ Breast Cancer by Syed, Anum K., Woodall, Ryan, Whisenant, Jennifer G., Yankeelov, Thomas E., Sorace, Anna G.

“…The purpose of this study is to investigate imaging and histology-based measurements of intratumoral heterogeneity to evaluate early treatment response to…”
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Repeatability, reproducibility, and accuracy of quantitative mri of the breast in the community radiology setting by Sorace, Anna G., Wu, Chengyue, Barnes, Stephanie L., Jarrett, Angela M., Avery, Sarah, Patt, Debra, Goodgame, Boone, Luci, Jeffery J., Kang, Hakmook, Abramson, Richard G., Yankeelov, Thomas E., Virostko, John

“…Background Quantitative diffusion‐weighted MRI (DW‐MRI) and dynamic contrast‐enhanced MRI (DCE‐MRI) have the potential to impact patient care by providing…”
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Systemic Checkpoint Blockade by PD-L1 Single-Chain Antibody Confers Potent Antitumor Immunity and Long-term Survival by Wang, Hong, Khattar, Vinayak, Hensel, Jonathan A, Ashton, Reading, Lu, Yun, Sorace, Anna G, Wang, Yong, Deshane, Jessy S, Mieher, Joshua L, Deivanayagam, Champion, Ponnazhagan, Selvarangan

“…Immune checkpoint inhibitors (ICI) are promising in adjuvant settings for solid tumors and hematologic malignancies. They are currently used in the treatment…”
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Evaluating the immunologically "cold" tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models by Lu, Yun, Houson, Hailey A, Gallegos, Carlos A, Mascioni, Alessandro, Jia, Fang, Aivazian, Argin, Song, Patrick N, Lynch, Shannon E, Napier, Tiara S, Mansur, Ameer, Larimer, Benjamin M, Lapi, Suzanne E, Hanker, Ariella B, Sorace, Anna G

“…Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response…”
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The effects of IKK-beta inhibition on early NF-kappa-B activation and transcription of downstream genes by Bloom, Meghan J., Saksena, Sachit D., Swain, George P., Behar, Marcelo S., Yankeelov, Thomas E., Sorace, Anna G.

“…Small molecule approaches targeting the nuclear factor kappa B (NF-kB) pathway, a regulator of inflammation, have thus far proven unsuccessful in the clinic in…”
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Dual anti-HER2/EGFR inhibition synergistically increases therapeutic effects and alters tumor oxygenation in HNSCC by Song, Patrick N., Lynch, Shannon E., DeMellier, Chloe T., Mansur, Ameer, Gallegos, Carlos A., Wright, Brian D., Hartman, Yolanda E., Minton, Laura E., Lapi, Suzanne E., Warram, Jason M., Sorace, Anna G.

“…Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and hypoxia are associated with radioresistance. The goal of this…”
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Quantitative multiparametric MRI predicts response to neoadjuvant therapy in the community setting by Virostko, John, Sorace, Anna G, Slavkova, Kalina P, Kazerouni, Anum S, Jarrett, Angela M, DiCarlo, Julie C, Woodard, Stefanie, Avery, Sarah, Goodgame, Boone, Patt, Debra, Yankeelov, Thomas E

“…The purpose of this study was to determine whether advanced quantitative magnetic resonance imaging (MRI) can be deployed outside of large, research-oriented…”
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Multiparametric Analysis of Longitudinal Quantitative MRI data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer by Syed, Anum K, Whisenant, Jennifer G, Barnes, Stephanie L, Sorace, Anna G, Yankeelov, Thomas E

“…This study identifies physiological tumor habitats from quantitative magnetic resonance imaging (MRI) data and evaluates their alterations in response to…”
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[18F]FMISO-PET imaging reveals the role of hypoxia severity in checkpoint blockade response by McNeal, Kaytlyn C., Reeves, Kirsten M., Song, Patrick N., Lapi, Suzanne E., Sorace, Anna G., Larimer, Benjamin M.

“…Hypoxia within the tumor microenvironment is a critical factor influencing the efficacy of immunotherapy, including immune checkpoint inhibition. Insufficient…”
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Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer by Bloom, Meghan J, Jarrett, Angela M, Triplett, Todd A, Syed, Anum K, Davis, Tessa, Yankeelov, Thomas E, Sorace, Anna G

“…Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer…”
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Quantitative magnetic resonance imaging and tumor forecasting of breast cancer patients in the community setting by Jarrett, Angela M., Kazerouni, Anum S., Wu, Chengyue, Virostko, John, Sorace, Anna G., DiCarlo, Julie C., Hormuth, David A., Ekrut, David A., Patt, Debra, Goodgame, Boone, Avery, Sarah, Yankeelov, Thomas E.

“…This protocol describes a complete data acquisition, analysis and computational forecasting pipeline for employing quantitative MRI data to predict the…”
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Investigating tumor-host response dynamics in preclinical immunotherapy experiments using a stepwise mathematical modeling strategy by Jarrett, Angela M, Song, Patrick N, Reeves, Kirsten, Lima, Ernesto A B F, Larimer, Benjamin, Yankeelov, Thomas E, Sorace, Anna G

“…Immunotherapies such as checkpoint blockade to PD1 and CTLA4 can have varied effects on individual tumors. To quantify the successes and failures of these…”
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