Response to Mycobacterium tuberculosis antigens is enhanced by monoclonal antibodies

T lymphocytes purified from peripheral blood of tuberculosis patients and from healthy skin test PPD-positive subjects show a remarkably increased proliferative response in culture to purified protein derivative (PPD) when three anti-mycobacterial monoclonal antibodies are added together with the an...

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Bibliographic Details
Published in:	Bollettino della Societa italiana di biologia sperimentale Vol. 67; no. 5; p. 517
Main Authors:	Damiani, G, Soprani, R, Rapallo, A, Bisio, S, Wang, J
Format:	Journal Article
Language:	English
Published:	Italy 01-05-1991
Subjects:	Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antigen-Presenting Cells - immunology Antigens, Bacterial - immunology Bacterial Proteins - immunology Cells, Cultured Humans Lymphocyte Activation Mycobacterium tuberculosis - immunology T-Lymphocytes - immunology Tuberculin - immunology
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Summary:	T lymphocytes purified from peripheral blood of tuberculosis patients and from healthy skin test PPD-positive subjects show a remarkably increased proliferative response in culture to purified protein derivative (PPD) when three anti-mycobacterial monoclonal antibodies are added together with the antigen. This indicates an important role played by antibodies in the T cell response to the tuberculous infection.
ISSN:	0037-8771