Search Results - "Soppa, Gopal K."

Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, transverse-tubule structure, and the cell surface by Ibrahim, Michael, Al Masri, Abeer, Navaratnarajah, Manoraj, Siedlecka, Urszula, Soppa, Gopal K, Moshkov, Alexey, Al-Saud, Sara Abou, Gorelik, Julia, Yacoub, Magdi H, Terracciano, Cesare M.N

“…Prolonged mechanical unloading (UN) of the heart is associated with detrimental changes to the structure and function of cardiomyocytes. The mechanisms…”
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Direct effects of apelin on cardiomyocyte contractility and electrophysiology by Farkasfalvi, Klára, Stagg, Mark A., Coppen, Steven R., Siedlecka, Urszula, Lee, Joon, Soppa, Gopal K., Marczin, Nándor, Szokodi, István, Yacoub, Magdi H., Terracciano, Cesare M.N.

“…Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the pathogenesis of atrial fibrillation and heart failure. However, it is…”
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Heterotopic abdominal heart transplantation in rats for functional studies of ventricular unloading by Ibrahim, Michael, MA, Navaratnarajah, Manoraj, MRCS, Kukadia, Punam, BSc, Rao, Christopher, MRCS, Siedlecka, Urszula, PhD, Cartledge, James E., MSc, Soppa, Gopal K., PhD, Van Doorn, Carin, MD, Yacoub, Magdi H., FRS, Terracciano, Cesare M., MD, PhD

“…Abstract Introduction Chronic changes in mechanical load regulate long-term cardiac function. Chronic overload of the ventricle results in myocardial failure…”
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Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle by Soppa, Gopal K R, Smolenski, Ryszard T, Latif, Najma, Yuen, Ada H Y, Malik, Aalya, Karbowska, Joanna, Kochan, Zdzislaw, Terracciano, Cesare M N, Yacoub, Magdi H

“…Clenbuterol (Clen), a beta(2)-agonist, is known to produce skeletal and myocardial hypertrophy. This compound has recently been used in combination with left…”
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Prolonged Mechanical Unloading Reduces Myofilament Sensitivity to Calcium and Sarcoplasmic Reticulum Calcium Uptake Leading to Contractile Dysfunction by Soppa, Gopal K.R., MRCS, Lee, Joon, MRCS, Stagg, Mark A., PhD, Siedlecka, Urszula, PhD, Youssef, Samuel, MBBS, Yacoub, Magdi H., FRS, Terracciano, Cesare M.N., MD, PhD

“…Background Prolonged unloading using left ventricular (LV) assist devices (LVADs) leads to unloading-induced atrophy with altered cardiomyocyte contractility…”
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Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes by Lee, Joon, Stagg, Mark A, Fukushima, Satsuki, Soppa, Gopal K R, Siedlecka, Urszula, Youssef, Samuel J, Suzuki, Ken, Yacoub, Magdi H, Terracciano, Cesare M N

“…Adult progenitor cell transplantation has been proposed for the treatment of heart failure, but the mechanisms effecting functional improvements remain…”
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Left ventricular assist device-induced molecular changes in the failing myocardium by Soppa, Gopal KR, Barton, Paul JR, Terracciano, Cesare MN, Yacoub, Magdi H

“…PURPOSE OF REVIEWThere is considerable increase in the use of left ventricular assist devices for the treatment of severe heart failure. Traditionally viewed…”
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Impact of European Society of Cardiology and European Association for Cardiothoracic Surgery Guidelines on Myocardial Revascularization on the activity of percutaneous coronary intervention and coronary artery bypass graft surgery for stable coronary artery disease by Yates, Martin T., MRCS, Soppa, Gopal K.R., MRCS, Valencia, Oswaldo, MD, Jones, Sion, MRCS, Firoozi, Sami, FRCP, Jahangiri, Marjan, FRCS(CTh)

“…Objective Joint guidelines on myocardial revascularization were published by the European Society of Cardiology and European Association for Cardiothoracic…”
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Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure by Soppa, Gopal K.R., Lee, Joon, Stagg, Mark A., Felkin, Leanne E., Barton, Paul J.R., Siedlecka, Urszula, Youssef, Samuel, Yacoub, Magdi H., Terracciano, Cesare M.N.

“…Aims Combined left ventricular assist device (LVAD) and pharmacological therapy has been proposed to favour myocardial recovery in patients with end-stage…”
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Cytoskeletal Protein 4.1R Affects Repolarization and Regulates Calcium Handling in the Heart by Stagg, Mark A, Carter, Edward, Sohrabi, Nadia, Siedlecka, Urszula, Soppa, Gopal K, Mead, Fiona, Mohandas, Narla, Taylor-Harris, Pamela, Baines, Anthony, Bennett, Pauline, Yacoub, Magdi H, Pinder, Jennifer C, Terracciano, Cesare M.N

“…The 4.1 proteins are a family of multifunctional adaptor proteins. They promote the mechanical stability of plasma membranes by interaction with the…”
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What is the optimal revascularization technique for isolated disease of the left anterior descending artery: minimally invasive direct coronary artery bypass or percutaneous coronary intervention? by Patel, Akshay J., Yates, Martin T., Soppa, Gopal K.R.

“…A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, ‘What is the optimal revascularization…”
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The role of the cardiac Na+/Ca2+ exchanger in reverse remodeling: relevance for LVAD-recovery by Terracciano, Cesare M N, Koban, Maren U, Soppa, Gopal K, Siedlecka, Urszula, Lee, Joon, Stagg, Mark A, Yacoub, Magdi H

“…Different strategies can, at least in certain conditions, prevent or reverse myocardial remodeling due to heart failure and induce myocardial functional…”
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A Gene Expression Profile of the Myocardial Response to Clenbuterol by Lara-Pezzi, Enrique, Terracciano, Cesare M. N., Soppa, Gopal K. R., Smolenski, Ryszard T., Felkin, Leanne E., Yacoub, Magdi H., Barton, Paul J. R.

“…Clenbuterol is currently being used as part of a clinical trial into a novel therapeutic approach for the treatment of end-stage heart failure. The purpose of…”
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Identification of cell-specific soluble mediators and cellular targets during cell therapy for the treatment of heart failure by Lee, Joon, Stagg, Mark A, Siedlecka, Urszula, Latif, Najma, Soppa, Gopal Kr, Yacoub, Magdi, Terracciano, Cesare Mn

“…Cell therapy, the transplantation of progenitor cells into the myocardium, has been proposed as a possible treatment strategy for heart failure. Despite the…”
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Abstract 580: Skeletal Myoblasts and Bone Marrow-Derived Cells Enhance the Contractile Function of Isolated Failing Cardiomyocytes in Co-culture by Lee, Joon, Stagg, Mark A, Soppa, Gopal K, Siedlecka, Urszula, Yacoub, Magdi H, Terracciano, Cesare M

“…Abstract only Cell transplantation has been shown to enhance ventricular function in heart failure. However, the low numbers of surviving transplanted cells…”
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The Role of the Cardiac Na + /Ca 2+ Exchanger in Reverse Remodeling: Relevance for LVAD–Recovery by TERRACCIANO, CESARE M. N., KOBAN, MAREN U., SOPPA, GOPAL K., SIEDLECKA, URSZULA, LEE, JOON, STAGG, MARK A., YACOUB, MAGDI H.

“…Different strategies can, at least in certain conditions, prevent or reverse myocardial remodeling due to heart failure and induce myocardial functional…”
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The Role of the Cardiac Na+/Ca2+ Exchanger in Reverse Remodeling by TERRACCIANO, CESARE M. N., KOBAN, MAREN U., SOPPA, GOPAL K., SIEDLECKA, URSZULA, LEE, JOON, STAGG, MARK A., YACOUB, MAGDI H.

“…:  Different strategies can, at least in certain conditions, prevent or reverse myocardial remodeling due to heart failure and induce myocardial functional…”
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Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure : Focus on the cardiac sarcomere by SOPPA, Gopal K. R, LEE, Joon, STAGG, Mark A, FELKIN, Leanne E, BARTON, Paul J. R, SIEDLECKA, Urszula, YOUSSEF, Samuel, YACOUB, Magdi H, TERRACCIANO, Cesare M. N

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Abstract 1082: Cytoskeletal Protein 4.1R Affects Repolarisation And Regulates Calcium Handling In The Heart by Terracciano, Cesare M, Sohrabi, Nadia, Siedlecka, Urszula, Stagg, Mark A, Soppa, Gopal K, Lee, Joon, Barton, Paul J, Bennett, Pauline, Pinder, Jennifer C, Yacoub, Magdi H

“…Abstract only The 4.1 proteins are a family of multifunctional adaptor proteins that organise signalling/transport/cell adhesion molecules. They are capable of…”
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Heart Team Discussion of Patients with Severe Coronary Artery Disease in the United Kingdom following Joint ESC / EACTS Guidelines on Myocardial Revascularization – A Multi-Centre Study by Yates, Martin T., MRCS, Balmforth, Damian, MRCS, Soppa, Gopal KR., MRCS, Uppal, Rakesh, FRCS(CTh), Desai, Jatin, FRCS(CTh), Jahangiri, Marjan, FRCS(CTh)

“…Abstract Objective Joint European Society of Cardiology and European Association for Cardiothoracic Surgery (ESC/EACTS) Guidelines on Myocardial…”
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