Search Results - "Soos, Maria A"

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis by Semple, Robert K, Sleigh, Alison, Murgatroyd, Peter R, Adams, Claire A, Bluck, Les, Jackson, Sarah, Vottero, Alessandra, Kanabar, Dipak, Charlton-Menys, Valentine, Durrington, Paul, Soos, Maria A, Carpenter, T Adrian, Lomas, David J, Cochran, Elaine K, Gorden, Phillip, O'Rahilly, Stephen, Savage, David B

“…Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic…”
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truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia by Dash, Satya, Sano, Hiroyuki, Rochford, Justin J, Semple, Robert K, Yeo, Giles, Hyden, Caroline S.S, Soos, Maria A, Clark, James, Rodin, Andrew, Langenberg, Claudia, Druet, Celine, Fawcett, Katherine A, Tung, Y.C. Loraine, Wareham, Nicolas J, Barroso, Inês, Lienhard, Gustav E, O'Rahilly, Stephen, Savage, David B

“…Tre-2, BUB2, CDC16, 1 domain family member 4 (TBC1D4) (AS160) is a Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter 4 (GLUT4)…”
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Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies by Semple, Robert K, Halberg, Nils H, Burling, Keith, Soos, Maria A, Schraw, Todd, Luan, Jian'an, Cochran, Elaine K, Dunger, David B, Wareham, Nicholas J, Scherer, Philipp E, Gorden, Phillip, O'Rahilly, Stephen

“…Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies Robert K. Semple 1 , Nils…”
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Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes by TAN, Karen, KIMBER, Wendy A, LUAN, Jianan, SOOS, Maria A, SEMPLE, Robert K, WAREHAM, Nicholas J, O'RAHILLY, Stephen, BARROSO, Ines

“…Analysis of Genetic Variation in Akt2/PKB-β in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes Karen Tan 1 2 ,…”
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Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling by Jensen, Jørgen, Jebens, Einar, Brennesvik, Erlend O, Ruzzin, Jérôme, Soos, Maria A, Engebretsen, Ellen M L, O'Rahilly, Stephen, Whitehead, Jonathan P

“…Insulin-stimulated glucose uptake and incorporation of glucose into skeletal muscle glycogen contribute to physiological regulation of blood glucose…”
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Genetic Variants in Human Sterol Regulatory Element Binding Protein-1c in Syndromes of Severe Insulin Resistance and Type 2 Diabetes by Laudes, Matthias, Barroso, Inês, Luan, Jian’an, Soos, Maria A., Yeo, Giles, Meirhaeghe, Aline, Logie, Lisa, Vidal-Puig, Antonio, Schafer, Alan J., Wareham, Nick J., O’Rahilly, Stephen

“…Genetic Variants in Human Sterol Regulatory Element Binding Protein-1c in Syndromes of Severe Insulin Resistance and Type 2 Diabetes Matthias Laudes 1 , Inês…”
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Role of Insulin Receptor Dimerization Domains in Ligand Binding, Cooperativity, and Modulation by Anti-receptor Antibodies by Surinya, Katharina Helen, Molina, Laurence, Soos, Maria A., Brandt, Jakob, Kristensen, Claus, Siddle, Kenneth

“…To define the structures within the insulin receptor (IR) that are required for high affinity ligand binding, we have used IR fragments consisting of four…”
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Autoimmune Forms of Hypoglycemia by Lupsa, Beatrice C., Chong, Angeline Y., Cochran, Elaine K., Soos, Maria A., Semple, Robert K., Gorden, Phillip

“…Autoimmune syndromes are a rare cause of hypoglycemia characterized by elevated levels of insulin in the presence of either anti-insulin antibodies (insulin…”
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A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2 by George, Stella, Rochford, Justin J., Wolfrum, Christian, Gray, Sarah L., Schinner, Sven, Wilson, Jenny C., Soos, Maria A., Murgatroyd, Peter R., Williams, Rachel M., Acerini, Carlo L., Dunger, David B., Barford, David, Umpleby, A. Margot, Wareham, Nicholas J., Davies, Huw Alban, Schafer, Alan J., Stoffel, Markus, O'Rahilly, Stephen, Barroso, Inês

“…Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we…”
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Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction by Semple, Robert K., Cochran, Elaine K., Soos, Maria A., Burling, Keith A., Savage, David B., Gorden, Phillip, O'Rahilly, Stephen

“…Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction Clinical utility in severe insulin resistance Robert K. Semple , MB, PHD 1 , Elaine K. Cochran ,…”
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Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction : Clinical utility in severe insulin resistance by SEMPLE, Robert K, COCHRAN, Elaine K, SOOS, Maria A, BURLING, Keith A, SAVAGE, David B, GORDEN, Phillip, O'RAHILLY, Stephen

“…Severe insulin resistance is associated with high morbidity. Identification of severely insulin-resistant patients who have genetic or acquired insulin…”
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Congenital leptin deficiency is associated with severe early-onset obesity in humans by O'Rahilly, Stephen, Montague, Carl T, Farooqi, I. Sadaf, Whitehead, Jonathan P, Soos, Maria A, Rau, Harald, Wareham, Nicholas J, Sewter, Ciaran P, Digby, Janet E, Mohammed, Shehla N, Hurst, Jane A, Cheetham#, Christopher H, Earley#, Alison R, Barnett, Anthony H, Prins, Johannes B

“…The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has…”
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Digenic inheritance of severe insulin resistance in a human pedigree by O'Rahilly, Stephen, Savage, David B, Agostini, Maura, Barroso, Inês, Gurnell, Mark, Luan, Jian'an, Meirhaeghe, Aline, Harding, Anne-Helen, Ihrke, Gudrun, Rajanayagam, Odelia, Soos, Maria A, George, Stella, Berger, Dirk, Thomas, E. Louise, Bell, Jimmy D, Meeran, Karim, Ross, Richard J, Vidal-Puig, Antonio, Wareham, Nicholas J, Chatterjee, V. Krishna K, Schafer, Alan J

“…Impaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance. Although…”
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Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting by Bailyes, E M, Navé, B T, Soos, M A, Orr, S R, Hayward, A C, Siddle, K

“…The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be…”
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Multiple molecular mechanisms of insulin receptor dysfunction in a patient with Donohue syndrome by WHITEHEAD, J. P, SOOS, M. A, JACKSON, R, TASIC, V, KOCOVA, M, O'RAHILLY, S

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Functional activation of mutant human insulin receptor by monoclonal antibody by Krook, A, Soos, M A, Kumar, S, Siddle, K, O'Rahilly, S

“…A mutant insulin receptor, Ser323Leu, has been reported in two severely insulin-resistant patients with Rabson-Mendenhall syndrome. In both cases, extreme…”
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Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance by Whittaker, J, Soos, M A, Siddle, K

“…Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance. J Whittaker , M A Soos and K Siddle…”
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Analysis of Genetic Variation in Akt2/PKB-[beta] in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes by Tan, Karen, Kimber, Wendy A, Luan, Jian'an, Soos, Maria A

“…We previously reported a family in which a heterozygous missense mutation in Akt2 led to a dominantly inherited syndrome of insulin-resistant diabetes and…”
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Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle by Whitehead, J P, Soos, M A, Aslesen, R, O'rahilly, S, Jensen, J

“…The initial stages of insulin-stimulated glucose uptake are thought to involve tyrosine phosphorylation of insulin receptor substrates (IRSs), which recruit…”
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Class II Phosphoinositide 3-Kinase Is Activated by Insulin but Not by Contraction in Skeletal Muscle by Soos, Maria A., Jensen, Jørgen, Brown, Richard A., O'Rahilly, Stephen, Shepherd, Peter R., Whitehead, Jonathan P.

“…While the role of the class IA phosphoinositide 3-kinase (PI 3-kinase) in insulin signaling is well established, little is known about the role of the class II…”
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