Search Results - "Soond, Surinder M."

Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer by Parodi, Alessandro, Rudzińska, Magdalena, Deviatkin, Andrei A, Soond, Surinder M, Baldin, Alexey V, Zamyatnin, Jr, Andrey A

“…Brain tumors are characterized by very high mortality and, despite the continuous research on new pharmacological interventions, little therapeutic progress…”
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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance by Rudzińska, Magdalena, Parodi, Alessandro, Soond, Surinder M, Vinarov, Andrey Z, Korolev, Dmitry O, Morozov, Andrey O, Daglioglu, Cenk, Tutar, Yusuf, Zamyatnin, Jr, Andrey A

“…Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove…”
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Albumin Nanovectors in Cancer Therapy and Imaging by Parodi, Alessandro, Miao, Jiaxing, Soond, Surinder M, Rudzińska, Magdalena, Zamyatnin, Jr, Andrey A

“…Albumin nanovectors represent one of the most promising carriers recently generated because of the cost-effectiveness of their fabrication, biocompatibility,…”
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BH3-mimetics: recent developments in cancer therapy by Townsend, Paul A, Kozhevnikova, Maria V, Cexus, Olivier N F, Zamyatnin, Jr, Andrey A, Soond, Surinder M

“…The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis…”
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Helicobacter pylori and gastric cancer: a lysosomal protease perspective by Soond, Surinder M., Zamyatnin, Andrey A.

“…The intimate involvement of pathogens with the heightened risk for developing certain cancers is an area of research that has captured a great deal of…”
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Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis by Soond, Surinder M, Kozhevnikova, Maria V, Savvateeva, Lyudmila V, Townsend, Paul A, Zamyatnin, Jr, Andrey A

“…Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic…”
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Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer by Soond, Surinder M, Kozhevnikova, Maria V, Townsend, Paul A, Zamyatnin, Jr, Andrey A

“…In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and…”
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Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level by Pais, Helio, Nicolas, Francisco Esteban, Soond, Surinder M, Swingler, Tracey E, Clark, Ian M, Chantry, Andrew, Moulton, Vincent, Dalmay, Tamas

“…mRNA profiling is routinely used to identify microRNA targets, however, this high-throughput technology is not suitable for identifying targets regulated only…”
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Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer by Soond, Surinder M., Kozhevnikova, Maria V., Townsend, Paul A., Zamyatnin, Andrey A.

“…As the direct regulatory role of p53 and some of its isoform proteins are becoming established in modulating gene expression in cancer research, another aspect…”
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Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms by Wahl, Lloyd C, Watt, Jessica E, Yim, Hiu T T, De Bourcier, Danielle, Tolchard, James, Soond, Surinder M, Blumenschein, Tharin M A, Chantry, Andrew

“…WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform…”
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Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis by Soond, Surinder M, Savvateeva, Lyudmila V, Makarov, Vladimir A, Gorokhovets, Neonila V, Townsend, Paul A, Zamyatnin, Jr, Andrey A

“…Certain lysosomal cathepsin proteins have come into focus as being good candidates for therapeutic targeting, based on them being over-expressed in a variety…”
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Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design by Frolova, Anastasia S, Petushkova, Anastasiia I, Makarov, Vladimir A, Soond, Surinder M, Zamyatnin, Jr, Andrey A

“…Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins,…”
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Harnessing the Potential of Killers and Altruists within the Microbial Community: A Possible Alternative to Antibiotic Therapy? by Ikryannikova, Larisa N, Kurbatov, Leonid K, Soond, Surinder M, Zamyatnin, Jr, Andrey A

“…In the context of a post-antibiotic era, the phenomenon of microbial allolysis, which is defined as the partial killing of bacterial population induced by…”
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The biological basis and clinical symptoms of CAR-T therapy-associated toxicites by Titov, Aleksei, Petukhov, Alexey, Staliarova, Alena, Motorin, Dmitriy, Bulatov, Emil, Shuvalov, Oleg, Soond, Surinder M., Piacentini, Mauro, Melino, Gerry, Zaritskey, Andrey, Barlev, Nickolai A.

“…Currently, immunotherapy is attracting a lot of attention and may potentially become a leading approach in the treatment of cancer. One emerging therapeutic,…”
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Targeting G protein-coupled receptors in cancer therapy by Soond, Surinder M, Zamyatnin, Jr, Andrey A

“…As basic research into GPCR signaling and its association with disease has come into fruition, greater clarity has emerged with regards to how these receptors…”
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New targets of urocortin-mediated cardioprotection by Barry, Seán P, Lawrence, Kevin M, McCormick, James, Soond, Surinder M, Hubank, Mike, Eaton, Simon, Sivarajah, Ahila, Scarabelli, Tiziano M, Knight, Richard A, Thiemermann, Christoph, Latchman, David S, Townsend, Paul A, Stephanou, Anastasis

“…The urocortin (UCN) hormones UCN1 and UCN2 have been shown previously to confer significant protection against myocardial ischaemia/reperfusion (I/R) injury;…”
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Lysine-specific post-translational modifications of proteins in the life cycle of viruses by Loboda, Anna P., Soond, Surinder M., Piacentini, Mauro, Barlev, Nickolai A.

“…The process of protein post-translational modifications (PTM) is one of the critical mechanisms of regulation of many cellular processes, which makes it an…”
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'Patchiness' and basic cancer research: unravelling the proteases by Soond, Surinder M, Kozhevnikova, Maria V, Zamyatnin Jr, Andrey A

“…The recent developments in Cathepsin protease research have unveiled a number of key observations which are fundamental to further our understanding of normal…”
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p73-mediated transcriptional activity is negatively regulated by Polo-like kinase 1 by Soond, Surinder M., Barry, Sean, Melino, Gerry, Knight, Richard A., Latchman, David S., Stephanou, Anastasis

“…Trans-activating (TA) p73 is a member of the p53 family of transcription factors and has been implicated in cell cycle regulation, apoptosis and developmental…”
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Beyond basic research: the contribution of cathepsin B to cancer development, diagnosis and therapy by Zamyatnin, Jr, Andrey A, Gregory, Levy C, Townsend, Paul A, Soond, Surinder M

“…In view of other candidate proteins from the cathepsin family of proteases holding great potential in being targeted during cancer therapy, the importance of…”
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