Search Results - "Soon Kang, Jong"

Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3- f ]quinoline Derivatives by Chaudhary, Chhabi Lal, Ko, Seungyun, Lee, Chaerim, Kim, Yerin, Jung, Chanhyun, Hyun, Soonsil, Kwon, Youngjoo, Kang, Jong-Soon, Jung, Jae-Kyung, Lee, Heesoon

“…With the several targets of cancer treatment, inhibition of DNA topoisomerase activity is one of the well-known focuses in cancer chemotherapy. Here, we…”
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Identification and Validation of a Selective Small Molecule Inhibitor Targeting the Diacylglycerol Acyltransferase 2 Activity by Kim, Mun Ock, Lee, Su Ui, Lee, Hyun-Jun, Choi, Kwangman, Kim, Hyeongki, Lee, Sangku, Oh, Soo Jin, Kim, Sunhong, Kang, Jong Soon, Lee, Hyun Sun, Kwak, Young-Shin, Cho, Sungchan

“…Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis. Findings from…”
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Anti‐tumor activity of WK88‐1, a novel geldanamycin derivative, in gefitinib‐resistant non‐small cell lung cancers with Met amplification by Jang, Won‐Jun, Jung, Sung‐Keun, Kang, Jong‐Soon, Jeong, Joo‐Won, Bae, Moon‐Kyoung, Joo, Sang Hoon, Park, Gyu Hwan, Kundu, Joydeb K., Hong, Young‐Soo, Jeong, Chul‐Ho

“…Although epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) have been introduced for the treatment of non‐small cell lung cancer (NSCLC),…”
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Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells by Hong, Seung-Woo, Shin, Jae-Sik, Moon, Jai-Hee, Jung, Soo-A, Koh, Dong-In, Ryu, Yeaseong, Park, Yoon Sun, Kim, Do Yeon, Park, Sang-Soo, Hong, Jun Ki, Kim, Eun Ho, Kim, Mi Jin, Jeong, Hong-Rae, Bae, In Hwan, Ahn, Young-Gil, Suh, Kwee Hyun, Cho, Ig-Jun, Kang, Jong-Soon, Hong, Yong Sang, Lee, Jung Shin, Jin, Dong-Hoon, Kim, Tae Won

“…Summary Inhibitor of apoptosis proteins (IAPs) are overexpressed in the majority of cancers and prevent apoptosis by inhibiting caspases. IAPs have therefore…”
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Quinazolin‐4(3H)‐one‐Based Hydroxamic Acids: Design, Synthesis and Evaluation of Histone Deacetylase Inhibitory Effects and Cytotoxicity by Hieu, Doan Thanh, Anh, Duong Tien, Hai, Pham‐The, Thuan, Nguyen Thi, Huong, Le‐Thi‐Thu, Park, Eun Jae, Young Ji, A., Soon Kang, Jong, Phuong Dung, Phan Thi, Han, Sang‐Bae, Nam, Nguyen‐Hai

“…The present article describes the synthesis and biological activity of various series of novel hydroxamic acids incorporating quinazolin‐4(3H)‐ones as novel…”
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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells by Yoo, Hee Chan, Park, Seung Joon, Nam, Miso, Kang, Juwon, Kim, Kibum, Yeo, Joo Hye, Kim, Joon-Ki, Heo, Yunkyung, Lee, Hee Seung, Lee, Myeong Youl, Lee, Chang Woo, Kang, Jong Soon, Kim, Yun-Hee, Lee, Jinu, Choi, Junjeong, Hwang, Geum-Sook, Bang, Seungmin, Han, Jung Min

“…Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in…”
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Bisphenol A and its substitutes regulate human B cell survival via Nrf2 expression by Jang, Ju-Won, Lee, Jae-Wook, Yoon, Yeo Dae, Kang, Jong-Soon, Moon, Eun-Yi

“…B cells contribute to produce inflammatory cytokines and antibodies, to present autoantigens, and to interact with T cells, which lead to body defense and…”
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Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model by Choi, Yongseok, Park, Song-Kyu, Kim, Hwan Mook, Kang, Jong Soon, Yoon, Yeo Dae, Han, Sang Bae, Han, Jeung Whan, Yang, Jee Sun, Han, Gyoonhee

“…In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA),…”
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Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock by Kang, Jong Soon, Yoon, Yeo Dae, Cho, Ig Jun, Han, Mi Hwa, Lee, Chang Woo, Park, Song-Kyu, Kim, Hwan Mook

“…(R)-4-(3,4-Dihydro-8,8-dimethyl)-2H,8H-benzo[1,2-b:3,4-b']dipyran-3yl)-1,3-benzenediol (glabridin), a flavonoid present in licorice extract, is known to have…”
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Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway by Lee, Minji, Kim, Jong Hyun, Yoon, Ina, Lee, Chulho, Sichani, Mohammad Fallahi, Kang, Jong Soon, Kang, Jeonghyun, Guo, Min, Lee, Kang Young, Han, Gyoonhee, Kim, Sunghoon, Han, Jung Min

“…A protein synthesis enzyme, leucyl-tRNA synthetase (LRS), serves as a leucine sensor for the mechanistic target of rapamycin complex 1 (mTORC1), which is a…”
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Errata for Biological and Pharmaceutical Bulletin by Kim, Mun Ock, Lee, Su Ui, Lee, Hyun-Jun, Choi, Kwangman, Kim, Hyeongki, Lee, Sangku, Oh, Soo Jin, Kim, Sunhong, Kang, Jong Soon, Lee, Hyun Sun, Kwak, Young-Shin, Cho, Sungchan

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Low Dose Estrogen Supplementation Reduces Mortality of Mice in Estrogen-Dependent Human Tumor Xenograft Model by Kang, Jong Soon, Kang, Moo Rim, Han, Sang-Bae, Yoon, Won Kee, Kim, Jang Hyun, Lee, Taek Chang, Lee, Chang Woo, Lee, Ki Hoon, Lee, Kiho, Park, Song-Kyu, Kim, Hwan Mook

“…Breast cancer is one of the most frequent female cancers in the Western world. Perturbation of estrogen levels by hormone replacement therapy or pregnancy is…”
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B cell-activating factor is a novel diagnosis parameter for asthma by Kang, Jong-Soon, Yoon, Yeo-Dae, Ahn, Joong-Hyun, Kim, Seok-Chan, Kim, Kwan-Hyoung, Kim, Hwan-Mook, Moon, Eun-Yi

“…Asthma is a life-threatening immediate-type allergic disease. B cell-activating factor (BAFF) is a key regulator of B lymphocyte development and is required to…”
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Inhibition of Phenotypic and Functional Maturation of Dendritic Cells by Manassantin A by Kim, Jee Youn, Kang, Jong Soon, Kim, Hwan Mook, Kim, Young Kook, Lee, Hong Kyung, Song, Sukgil, Hong, Jin Tae, Kim, Youngsoo, Han, Sang-Bae

“…Manassantin A (MSA) inhibits nitric oxide production by macrophages through the inhibition of NF-κB activation, but the effect of MSA on dendritic cells has…”
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Pyrrole-Containing Alkaloids from a Marine-Derived Actinobacterium Streptomyces zhaozhouensis and Their Antimicrobial and Cytotoxic Activities by Heo, Chang-Su, Kang, Jong Soon, Kwon, Joo-Hee, Anh, Cao Van, Shin, Hee Jae

“…Two new alkaloids, streptopyrroles B and C ( and ), were discovered through a chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived…”
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Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction by Kim, Jong Hyun, Lee, Chulho, Lee, Minji, Wang, Haipeng, Kim, Kibum, Park, Seung Joon, Yoon, Ina, Jang, Jayun, Zhao, Hanchao, Kim, Hoi Kyoung, Kwon, Nam Hoon, Jeong, Seung Jae, Yoo, Hee Chan, Kim, Jae Hyun, Yang, Jee Sun, Lee, Myeong Youl, Lee, Chang Woo, Yun, Jieun, Oh, Soo Jin, Kang, Jong Soon, Martinis, Susan A., Hwang, Kwang Yeon, Guo, Min, Han, Gyoonhee, Han, Jung Min, Kim, Sunghoon

“…Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the…”
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Structure−Activity Relationship Studies of a Series of Novel δ-Lactam-Based Histone Deacetylase Inhibitors by Kim, Hwan Mook, Ryu, Dong-Kyu, Choi, Yongseok, Park, Bum Woo, Lee, Kiho, Han, Sang Bae, Lee, Chang-Woo, Kang, Moo-Rim, Kang, Jong Soon, Boovanahalli, Shanthaveerappa K, Park, Song-Kyu, Han, Jung Whan, Chun, Tae-Gyu, Lee, Hee-Yoon, Nam, Ky-Youb, Choi, Eun Hyun, Han, Gyoonhee

“…We synthesized a series of δ-lactam-based HDAC inhibitors that were identified with various degrees of anti-inflammatory and cell growth inhibitory activities…”
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Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway by Sim, Seongrak, Lee, Sumi, Ko, Seungyun, Phuong Bui, Bich, Linh Nguyen, Phuong, Cho, Jungsook, Lee, Kiho, Kang, Jong-Soon, Jung, Jae-Kyung, Lee, Heesoon

“…[Display omitted] •A new series of 1,2,3,4-tetrahydroisoquinoline derivatives were designed based on the chemical structures of previous potent NF-κB…”
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Streptoglycerides E-H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity by Shin, Hee Jae, Heo, Chang-Su, Anh, Cao Van, Yoon, Yeo Dae, Kang, Jong Soon

“…Four new streptoglycerides E-H ( - ), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete . The structures of - were…”
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Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities by Heo, Chang-Su, Kang, Jong Soon, Yang, Jeong-Wook, Lee, Min Ah, Lee, Hwa-Sun, Shin, Hee Jae

“…Chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, , resulted in the discovery of five new labdane-type…”
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