Search Results - "Soon, Rachel"

Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study by Kublin, James G, Murphy, Sean C, Maenza, Janine, Seilie, Annette M, Jain, Jay Prakash, Berger, David, Spera, Danielle, Zhao, Rong, Soon, Rachel L, Czartoski, Julie L, Potochnic, Meredith A, Duke, Elizabeth, Chang, Ming, Vaughan, Ashley, Kappe, Stefan H I, Leong, F Joel, Pertel, Peter, Prince, William T

“…KAF156 is a novel antimalarial drug that is active against both liver- and blood-stage Plasmodium parasites, including drug-resistant strains. Here, we…”
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The Combination of Colistin and Doripenem Is Synergistic against Klebsiella pneumoniae at Multiple Inocula and Suppresses Colistin Resistance in an In Vitro Pharmacokinetic/Pharmacodynamic Model by DERIS, Zakuan Z, YU, Heidi H, FORREST, Alan, PATERSON, David L, VELKOV, Tony, JIAN LI, NATION, Roger L, DAVIS, Kathryn, SOON, Rachel L, JACOB, Jovan, KU, Caron K, POUDYAL, Anima, BERGEN, Phillip J, TSUJI, Brian T, BULITTA, Jurgen B

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Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies by Rao, Gauri G, Ly, Neang S, Bulitta, Jürgen B, Soon, Rachel L, San Roman, Marie D, Holden, Patricia N, Landersdorfer, Cornelia B, Nation, Roger L, Li, Jian, Forrest, Alan, Tsuji, Brian T

“…Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing…”
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Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment by SOON, Rachel L, NATION, Roger L, COCKRAM, Stewart, MOFFATT, Jennifer H, HARPER, Marina, ADLER, Ben, BOYCE, John D, LARSON, Ian, JIAN LI

“…electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates…”
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Atomic Force Microscopy Investigation of the Morphology and Topography of Colistin-Heteroresistant Acinetobacter baumannii Strains as a Function of Growth Phase and in Response to Colistin Treatment by SOON, Rachel L, NATION, Roger L, HARTLEY, Patrick G, LARSON, Ian, JIAN LI

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Impact of Staphylococcus aureus accessory gene regulator (agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression by Soon, Rachel L, Lenhard, Justin R, Reilly, Irene, Brown, Tanya, Forrest, Alan, Tsuji, Brian T

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Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin–lipopolysaccharide binding interactions by Soon, Rachel L., Velkov, Tony, Chiu, Francis, Thompson, Philip E., Kancharla, Rashmi, Roberts, Kade, Larson, Ian, Nation, Roger L., Li, Jian

“…Fluorescence assays employing semisynthetic or commercial dansyl-polymyxin B have been widely employed to assess the affinity of polycations, including…”
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Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations by Soon, Rachel L, Lenhard, Justin R, Bulman, Zackery P, Holden, Patricia N, Kelchlin, Pamela, Steenbergen, Judith N, Friedrich, Lawrence V, Forrest, Alan, Tsuji, Brian T

“…Despite a dearth of new agents currently being developed to combat multidrug-resistant Gram-negative pathogens, the combination of ceftolozane and tazobactam…”
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The DGAT1 inhibitor pradigastat does not induce photosensitivity in healthy human subjects: a randomized controlled trial using three defined sunlight exposure conditions by Bauer, Daniel, Soon, Rachel L, Kulmatycki, Kenneth, Chen, Yuming, Noe, Adele, Chen, Jin, Dosik, Jonathan S, Meyers, Dan

“…The DGAT1 inhibitor, pradigastat, demonstrated a mild phototoxicity signal in preclinical studies. Therefore, this clinical trial was conducted to assess the…”
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Pharmacokinetic/pharmacodynamic evaluation of the efficacy and safety of daptomycin against Staphylococcus aureus by Soon, Rachel L, Turner, Stuart J, Forrest, Alan, Tsuji, Brian T, Brown, Jack

“…Abstract Daptomycin is a novel lipopeptide exhibiting concentration-dependent bactericidal activity against multidrug-resistant Gram-positive pathogens,…”
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In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing escherichia coli in a hollow-fibre infection model by Soon, Rachel L, Lenhard, Justin R, Bulman, Zackery P, Holden, Patricia N, Kelchlin, Pamela, Steenbergen, Judith N, Friedrich, Lawrence V, Forrest, Alan, Tsuji, Brian T

“…Highlights • Ceftolozane/tazobactam is highly active against certain Escherichia coli strains. • Diminished activity was observed against a CTX-M-15-producing…”
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Pharmacodynamic Variability beyond That Explained by MICs by Soon, Rachel L, Ly, Neang S, Rao, Gauri, Wollenberg, Lance, Yang, Kuo, Tsuji, Brian, Forrest, Alan

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Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy by Soon, Rachel L, Nation, Roger L, Harper, Marina, Adler, Ben, Boyce, John D, Tan, Chun-Hong, Li, Jian, Larson, Ian

“…Abstract The diminishing antimicrobial development pipeline has forced the revival of colistin as a last line of defence against infections caused by…”
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Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A by Velkov, Tony, Soon, Rachel L, Chong, Pei L, Huang, Johnny X, Cooper, Matthew A, Azad, Mohammad A K, Baker, Mark A, Thompson, Philip E, Roberts, Kade, Nation, Roger L, Clements, Abigail, Strugnell, Richard A, Li, Jian

“…The impact of under-acylation of lipid A on the interaction between Klebsiella pneumoniae LPS and polymyxins B and E was examined with fluorometric and…”
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Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis by Bruin, Gerard, Hasselberg, Anke, Koroleva, Irina, Milojevic, Julie, Calonder, Claudio, Soon, Rachel, Woessner, Ralph, Pariser, David M., Boutouyrie‐Dumont, Bruno

“…This open‐label disease‐drug–drug interaction study assessed whether blockade of the interleukin (IL)‐17A pathway by secukinumab and subsequent downregulation…”
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Preliminary Comparison of Major Adverse Outcomes in Patients With Nonalcoholic Fatty Liver Disease Initiated on Second-Line Antihyperglycemic Therapy by Kim, Rachel Soon-Yong

“…Objectives: To assess long-term hepatic and cardiovascular outcomes in patients with both nonalcoholic fatty liver disease (NAFLD) and type II diabetes who are…”
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GS07 - Nidufexor, a non-bile acid FXR agonist, decreases ALT and hepatic fat fraction in patients with NASH after 12 weeks dosing by Aspinall, Richard, Shennak, Mustafa, Stocia, George, Quinn, Dean, Javashvili, Lali, Molteni, Valentina, Ukomadu, Chinweike, Sohal, Bindi, Zhang, Yiming, Martic, Miljen, Avrameas, Alexandre, Kao, Sheena, Herve, Jacques, Soon, Rachel, Badman, Michael

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Nidufexor, a non-bile acid FXR agonist, decreases ALT and hepatic fat fraction in patients with NASH after 12 weeks dosing by Aspinall, Richard, Shennak, Mustafa, Stocia, George, Quinn, Dean, Javashvili, Lali, Molteni, Valentina, Ukomadu, Chinweike, Sohal, Bindi, Zhang, Yiming, Martic, Miljen, Avrameas, Alexandre, Kao, Sheena, Herve, Jacques, Soon, Rachel, Badman, Michael

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Cell surface hydrophobicity of colistin-susceptible versus -resistant Acinetobacter baumannii determined by contact angles: methodological considerations and implications by Soon, Rachel L., Li, Jian, Boyce, John D., Harper, Marina, Adler, Ben, Larson, Ian, Nation, Roger L.

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Proposing a Foundational IoT Smart Planter Concept towards Reducing Carbon Footprint in Malaysia via Gamification by Philimon, Sheena Punai, Tsun Tee, Mark Kit, Yan Lo, Chyzien Chang, Hung Ho, Dexter Chu, Yan Chieng, Jake Zen, Bee Lian Soon, Rachel May

“…The rise in the concentration of greenhouse gases, predominantly carbon dioxide (CO 2 ), has contributed to the rising rate of climate change and global…”
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