Search Results - "Soo-Hyun Cho"

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids by Mun, Seon Ju, Ryu, Jae-Sung, Lee, Mi-Ok, Son, Ye Seul, Oh, Soo Jin, Cho, Hyun-Soo, Son, Mi-Young, Kim, Dae-Soo, Kim, Su Jung, Yoo, Hyun Ju, Lee, Ho-Joon, Kim, Janghwan, Jung, Cho-Rok, Chung, Kyung-Sook, Son, Myung Jin

“…[Display omitted] •Pluripotent stem cell (PSC)-derived expandable human hepatocyte-like liver organoids were generated.•PSC-derived human hepatic organoids are…”
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The Epigenetic Regulation of HCC Metastasis by Han, Tae-Su, Ban, Hyun Seung, Hur, Keun, Cho, Hyun-Soo

“…Epigenetic alterations, such as histone modification, DNA methylation, and miRNA-mediated processes, are critically associated with various mechanisms of…”
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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers by Hayami, Shinya, Kelly, John D., Cho, Hyun‐Soo, Yoshimatsu, Masanori, Unoki, Motoko, Tsunoda, Tatsuhiko, Field, Helen I., Neal, David E., Yamaue, Hiroki, Ponder, Bruce A.J., Nakamura, Yusuke, Hamamoto, Ryuji

“…A number of histone demethylases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human disease like…”
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Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors by Koh, Eunhee, Kim, Uijin, Cho, Hyun-Soo

“…Pathogenic bacteria encode virulent glycosyltransferases that conjugate various glycans onto host crucial proteins, which allows adhesion to mammalian cells…”
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Colorectal adenocarcinoma‐derived EGFR mutants are oncogenic and sensitive to EGFR‐targeted monoclonal antibodies, cetuximab and panitumumab by Kim, Nayoung, Cho, Daseul, Kim, Hyunjin, Kim, Sujin, Cha, Young‐je, Greulich, Heidi, Bass, Adam, Cho, Hyun‐Soo, Cho, Jeonghee

“…Somatic mutations of epidermal growth factor receptor (EGFR) occur in ~3% of colorectal cancer (CRC) patients. Here, through systematic functional screening of…”
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Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker by Takawa, Masashi, Masuda, Ken, Kunizaki, Masaki, Daigo, Yataro, Takagi, Katsunori, Iwai, Yukiko, Cho, Hyun‐Soo, Toyokawa, Gouji, Yamane, Yuka, Maejima, Kazuhiro, Field, Helen I., Kobayashi, Takaaki, Akasu, Takayuki, Sugiyama, Masanori, Tsuchiya, Eijyu, Atomi, Yutaka, Ponder, Bruce A. J., Nakamura, Yusuke, Hamamoto, Ryuji

“…The emphasis in anticancer drug discovery has always been on finding a drug with great antitumor potential but few side‐effects. This can be achieved if the…”
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The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation by Morikawa, Momo, Tanaka, Yosuke, Cho, Hyun-Soo, Yoshihara, Masaharu, Hirokawa, Nobutaka

“…Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely…”
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Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR by Kim, Jiyoon, Noh, Shin Hye, Piao, He, Kim, Dong Hee, Kim, Kuglae, Cha, Jeong Seok, Chung, Woo Young, Cho, Hyun‐Soo, Kim, Joo Young, Lee, Min Goo

“…Endoplasmic reticulum (ER)‐to‐Golgi blockade or ER stress induces Golgi reassembly stacking protein (GRASP)‐mediated, Golgi‐bypassing cell‐surface trafficking…”
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Reflectance According to Cell Size, Foaming Ratio and Refractive Index of Microcellular Foamed Amorphous Polymer by Cha, Sung Woon, Cho, Soo-Hyun, Sohn, Joo Seong, Ryu, Youngjae, Ahn, Jeonghun

“…Microcellular foamed plastic has a cell size of approximately 0.1 to 10 microns inside a foamed polymer and a cell density in the range of 10 to 10 cells/cm …”
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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids by Jung, Kwang Bo, Lee, Hana, Son, Ye Seul, Lee, Mi-Ok, Kim, Young-Dae, Oh, Soo Jin, Kwon, Ohman, Cho, Sunwha, Cho, Hyun-Soo, Kim, Dae-Soo, Oh, Jung-Hwa, Zilbauer, Matthias, Min, Jeong-Ki, Jung, Cho-Rok, Kim, Janghwan, Son, Mi-Young

“…Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in…”
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Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy by Lee, Joong-jae, Choi, Hyo-Jung, Yun, Misun, Kang, YingJin, Jung, Ji-Eun, Ryu, Yiseul, Kim, Tae Yoon, Cha, Young-je, Cho, Hyun-Soo, Min, Jung-Joon, Chung, Chul-Woong, Kim, Hak-Sung

“…Targeted therapy based on protein–drug conjugates has attracted significant attention owing to its high efficacy and low side effects. However, efficient and…”
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Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia by Cho, Soo Hyun, Woo, Sookyoung, Kim, Changsoo, Kim, Hee Jin, Jang, Hyemin, Kim, Byeong C., Kim, Si Eun, Kim, Seung Joo, Kim, Jun Pyo, Jung, Young Hee, Lockhart, Samuel, Ossenkoppele, Rik, Landau, Susan, Na, Duk L., Weiner, Michael, Kim, Seonwoo, Seo, Sang Won

“…To characterize the course of Alzheimer’s disease (AD) over a longer time interval, we aimed to construct a disease course model for the entire span of the…”
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Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif by Kim, Kuglae, Kwon, Soon-Kyeong, Jun, Sung-Hoon, Cha, Jeong Seok, Kim, Hoyoung, Lee, Weontae, Kim, Jihyun F., Cho, Hyun-Soo

“…A novel light-driven chloride-pumping rhodopsin (ClR) containing an ‘NTQ motif’ in its putative ion conduction pathway has been discovered and functionally…”
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A liver‐specific gene expression panel predicts the differentiation status of in vitro hepatocyte models by Kim, Dae‐Soo, Ryu, Jea‐Woon, Son, Mi‐Young, Oh, Jung‐Hwa, Chung, Kyung‐Sook, Lee, Sugi, Lee, Jeong‐Ju, Ahn, Jun‐Ho, Min, Ju‐Sik, Ahn, Jiwon, Kang, Hyun Mi, Kim, Janghwan, Jung, Cho‐Rok, Kim, Nam‐Soon, Cho, Hyun‐Soo

“…Alternative cell sources, such as three‐dimensional organoids and induced pluripotent stem cell–derived cells, might provide a potentially effective approach…”
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EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression by Lee, Jinkwon, Kim, Kwangho, Ryu, Tae Young, Jung, Cho‐Rok, Lee, Moo‐Seung, Lim, Jung Hwa, Park, Kunhyang, Kim, Dae‐Soo, Son, Mi‐Young, Hamamoto, Ryuji, Cho, Hyun‐Soo

“…Dozens of histone methyltransferases have been identified and biochemically characterized, but the pathological roles of their dysfunction in human diseases…”
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Optimization of 3D hydrogel microenvironment for enhanced hepatic functionality of primary human hepatocytes by Lee, Ho‐Joon, Ahn, Jiwon, Jung, Cho‐Rock, Jeung, Yun‐Ji, Cho, Hyun‐Soo, Son, Myung Jin, Chung, Kyung‐Sook

“…Although primary human hepatocytes (PHHs) are the gold standard in drug efficacy and metabolism studies, long‐term survival of PHHs and maintenance of their…”
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Ameliorative Effect of Ginsenoside Rg6 in Periodontal Tissue Inflammation and Recovering Damaged Alveolar Bone by Lee, Won-Jin, Kim, Eun-Nam, Trang, Nguyen Minh, Lee, Jee-Hyun, Cho, Soo-Hyun, Choi, Hui-Ji, Song, Gyu-Yong, Jeong, Gil-Saeng

“…Periodontal disease is a chronic disease with a high prevalence, and in order to secure natural materials to prevent oral diseases, new materials that protect…”
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WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck by Saloura, Vassiliki, Cho, Hyun-Soo, Kiyotani, Kazuma, Alachkar, Houda, Zuo, Zhixiang, Nakakido, Makoto, Tsunoda, Tatsuhiko, Seiwert, Tanguy, Lingen, Mark, Licht, Jonathan, Nakamura, Yusuke, Hamamoto, Ryuji

“…Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are…”
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Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer by Ban, Hyun Seung, Han, Tae-Su, Hur, Keun, Cho, Hyun-Soo

“…Heat shock proteins (HSPs) are associated with various physiological processes (protein refolding and degradation) involved in the responses to cellular…”
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TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity by Kang, Sujin, Kim, Jaekyung, Park, Areum, Koh, Minsoo, Shin, Wonji, Park, Gayoung, Lee, Taeyun A., Kim, Hyung Jin, Han, Heonjong, Kim, Yongbo, Choi, Myung Kyung, Park, Jae Hyung, Lee, Eunhye, Cho, Hyun-Soo, Park, Hyun Woo, Cheon, Jae Hee, Lee, Sungwook, Park, Boyoun

“…The cortical actin cytoskeleton plays a critical role in maintaining intestinal epithelial integrity, and the loss of this architecture leads to chronic…”
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