Search Results - "Soo Suk Jung"

A Two‐Pronged Pulmonary Gene Delivery Strategy: A Surface‐Modified Fullerene Nanoparticle and a Hypotonic Vehicle by Chen, Daiqin, Liu, Shuai, Chen, Dinghao, Liu, Jinhao, Wu, Jerry, Wang, Han, Su, Yun, Kwak, Gijung, Zuo, Xinyuan, Rao, Divya, Cui, Honggang, Shu, Chunying, Suk, Jung Soo

“…Inhaled gene therapy poses a unique potential of curing chronic lung diseases, which are currently managed primarily by symptomatic treatments. However, it has…”
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Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin by Miller, Sean J., Philips, Thomas, Kim, Namho, Dastgheyb, Raha, Chen, Zhuoxun, Hsieh, Yi-Chun, Daigle, J. Gavin, Datta, Malika, Chew, Jeannie, Vidensky, Svetlana, Pham, Jacqueline T., Hughes, Ethan G., Robinson, Michael B., Sattler, Rita, Tomer, Raju, Suk, Jung Soo, Bergles, Dwight E., Haughey, Norman, Pletnikov, Mikhail, Hanes, Justin, Rothstein, Jeffrey D.

“…Despite expanding knowledge regarding the role of astroglia in regulating neuronal function, little is known about regional or functional subgroups of brain…”
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Disulfide disruption reverses mucus dysfunction in allergic airway disease by Morgan, Leslie E., Jaramillo, Ana M., Shenoy, Siddharth K., Raclawska, Dorota, Emezienna, Nkechinyere A., Richardson, Vanessa L., Hara, Naoko, Harder, Anna Q., NeeDell, James C., Hennessy, Corinne E., El-Batal, Hassan M., Magin, Chelsea M., Grove Villalon, Diane E., Duncan, Gregg, Hanes, Justin S., Suk, Jung Soo, Thornton, David J., Holguin, Fernando, Janssen, William J., Thelin, William R., Evans, Christopher M.

“…Airway mucus is essential for lung defense, but excessive mucus in asthma obstructs airflow, leading to severe and potentially fatal outcomes. Current asthma…”
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Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis by Andrade da Silva, Luisa Helena, Vieira, Juliana Borges, Cabral, Marianna Ribeiro, Antunes, Mariana Alves, Lee, Daiheon, Cruz, Fernanda Ferreira, Hanes, Justin, Rocco, Patricia Rieken Macedo, Morales, Marcelo Marcos, Suk, Jung Soo

“…Silicosis is an irreversible and progressive fibrotic lung disease caused by massive inhalation of crystalline silica dust at workplaces, affecting millions of…”
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Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients by Hida, Kaoru, Lai, Samuel K, Suk, Jung Soo, Won, Sang Y, Boyle, Michael P, Hanes, Justin

“…Norwalk virus and human papilloma virus, two viruses that infect humans at mucosal surfaces, have been found capable of rapidly penetrating human mucus…”
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An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy by Duncan, Gregg A, Kim, Namho, Colon-Cortes, Yanerys, Rodriguez, Jason, Mazur, Marina, Birket, Susan E, Rowe, Steven M, West, Natalie E, Livraghi-Butrico, Alessandra, Boucher, Richard C, Hanes, Justin, Aslanidi, George, Suk, Jung Soo

“…Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access…”
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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery by Suk, Jung Soo, Xu, Qingguo, Kim, Namho, Hanes, Justin, Ensign, Laura M.

“…Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a commonly used approach for improving the efficiency of drug and gene…”
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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy by Osman, Gizem, Rodriguez, Jason, Chan, Sze Yan, Chisholm, Jane, Duncan, Gregg, Kim, Namho, Tatler, Amanda L., Shakesheff, Kevin M., Hanes, Justin, Suk, Jung Soo, Dixon, James E.

“…The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are…”
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Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy by Mastorakos, Panagiotis, Adriana L. da Silva, Jane Chisholm, Eric Song, Won Kyu Choi, Michael P. Boyle, Marcelo M. Morales, Justin Hanes, Jung Soo Suk

“…Gene therapy has emerged as an alternative for the treatment of diseases refractory to conventional therapeutics. Synthetic nanoparticle-based gene delivery…”
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Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma by Wang, Feihu, Huang, Qian, Su, Hao, Sun, Mingjiao, Wang, Zeyu, Chen, Ziqi, Zheng, Mengzhen, Chakroun, Rami W, Monroe, Maya K, Chen, Daiqing, Wang, Zongyuan, Gorelick, Noah, Serra, Riccardo, Wang, Han, Guan, Yun, Suk, Jung Soo, Tyler, Betty, Brem, Henry, Hanes, Justin, Cui, Honggang

“…The unique cancer-associated immunosuppression in brain, combined with a paucity of infiltrating T cells, contributes to the low response rate and poor…”
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Particle tracking in drug and gene delivery research: State-of-the-art applications and methods by Schuster, Benjamin S., Ensign, Laura M., Allan, Daniel B., Suk, Jung Soo, Hanes, Justin

“…Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids…”
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Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats by Zhang, Clark, Nance, Elizabeth A., Mastorakos, Panagiotis, Chisholm, Jane, Berry, Sneha, Eberhart, Charles, Tyler, Betty, Brem, Henry, Suk, Jung Soo, Hanes, Justin

“…Glioblastoma multiforme (GBM) is highly invasive and uniformly fatal, with median survival<20months after diagnosis even with the most aggressive treatment…”
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Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model by Mead, Brian P, Kim, Namho, Miller, G. Wilson, Hodges, David, Mastorakos, Panagiotis, Klibanov, Alexander L, Mandell, James W, Hirsh, Jay, Suk, Jung Soo, Hanes, Justin, Price, Richard J

“…Therapies capable of decelerating, or perhaps even halting, neurodegeneration in Parkinson’s disease (PD) remain elusive. Clinical trials of PD gene therapy…”
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Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier by Wang, Ying‐Ying, Lai, Samuel K., Suk, Jung Soo, Pace, Amanda, Cone, Richard, Hanes, Justin

“…Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by…”
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Could recent advances in DNA-loaded nanoparticles lead to effective inhaled gene therapies? by Suk, Jung Soo

“…Specifically, commonly used cell lines are physiologically different from human primary cells, including their readily mitotic nature and distinct molecular…”
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Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier by Tang, Benjamin C, Dawson, Michelle, Lai, Samuel K, Wang, Ying-Ying, Suk, Jung Soo, Yang, Ming, Zeitlin, Pamela, Boyle, Michael P, Fu, Jie, Hanes, Justin

“…Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female…”
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Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation by Negron, Karina, Khalasawi, Namir, Lu, Billy, Ho, Chi-Ying, Lee, Jason, Shenoy, Siddharth, Mao, Hai-Quan, Wang, Tza-Huei, Hanes, Justin, Suk, Jung Soo

“…Gene therapy of malignant gliomas has shown a lack of clinical success to date due in part to inability of conventional gene vectors to achieve widespread gene…”
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Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier by Kim, Namho, Kwak, Gijung, Rodriguez, Jason, Livraghi-Butrico, Alessandra, Zuo, Xinyuan, Simon, Valentina, Han, Eric, Shenoy, Siddharth Kaup, Pandey, Nikhil, Mazur, Marina, Birket, Susan E, Kim, Anthony, Rowe, Steven M, Boucher, Richard, Hanes, Justin, Suk, Jung Soo

“…Inhaled gene therapy of muco-obstructive lung diseases requires a strategy to achieve therapeutically relevant gene transfer to airway epithelium covered by…”
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A Highly Translatable Dual‐arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor‐bearing Brain Tissues by Negron, Karina, Kwak, Gijung, Wang, Heng, Li, Haolin, Huang, Yi‐Ting, Chen, Shun‐Wen, Tyler, Betty, Eberhart, Charles G., Hanes, Justin, Suk, Jung Soo

“…Drug delivery nanoparticles (NPs) based entirely on materials generally recognized as safe that provide widespread parenchymal distribution following…”
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Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System by Mead, Brian P., Curley, Colleen T., Kim, Namho, Negron, Karina, Garrison, William J., Song, Ji, Rao, Divya, Miller, G. Wilson, Mandell, James W., Purow, Benjamin W., Suk, Jung Soo, Hanes, Justin, Price, Richard J.

“…Microbubble activation with focused ultrasound (FUS) facilitates the noninvasive and spatially‐targeted delivery of systemically administered therapeutics…”
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