Search Results - "Sonsire Fernández-Castillo"

OMV-based vaccine formulations against Shiga toxin producing Escherichia coli strains are both protective in mice and immunogenic in calves by Fingermann, Matias, Avila, Lucía, De Marco, Maria Belén, Vázquez, Luciana, Di Biase, Darío Nicolás, Müller, Andrea Verónica, Lescano, Mirta, Dokmetjian, José Christian, Fernández Castillo, Sonsire, Pérez Quiñoy, José Luis

“…Strains of Shiga toxin-producing Escherichia coli (STEC) can cause the severe Hemolytic Uremic Syndrome (HUS). Shiga toxins are protein toxins that bind and…”
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A Bordetella pertussis proteoliposome induces protection in mice without affecting the immunogenicity of diphtheria and tetanus toxoids in a trivalent formulation by Castillo, Sonsire Fernández, Chovel, Mario Landys, Hernández, Niurka Gutiérrez, González, Lorena Corcho, Blanco, Amaya, Hernández, Daily Serrano, Medina, Mildrey Fariñas, Tito, Maydelis Álvarez, Quiñoy, José Luis Pérez

“…In this study, a formulation of Bordetella pertussis proteoliposome (PLBp), diphtheria, and tetanus toxoids and alum (DT-PLBp) was evaluated as a trivalent…”
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Vacunas contra rotavirus: estado actual y tendencias futuras by Amin Blanco, Nevis, Fernández Castillo, Sonsire

“…Antes de la introducción de las vacunas contra el rotavirus en 2006, este patógeno era considerado la principal causa de gastroenteritis entre los niños…”
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Reactividad de sueros de ratones inmunizados con vesículas de membrana externa derivadas de Salmonella entérica by Yuneisy Guerra-Peña, Laura Remedios-Jiménez, Katherin Izquierdo-Fiallo, Elizabeth González-Aznar, Abel Fajardo-Sánchez, Sonsire Fernández-Castillo, Dagmar García-Rivera, José L. Pérez-Quiñoy

“…La fiebre tifoidea causada por Salmonella Paratyphi A (fiebre paratifoidea) es indistinguible de la producida por Salmonella Typhi y el grado de incidencia ha…”
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Condiciones de adsorción de un candidato vacunal basado en vesículas de membrana externa derivada de Salmonella Paratyphi A en adyuvantes de aluminio by Mabel Hernández-Cedeño, Caridad Zayas-Vignier, José Luis Pérez-Quiñoy, Kirenia Blain-Torres, Jessy Pedroso-Fernández, Jean Pierre Soubal-Mora, Sonsire Fernández-Castillo, Reinaldo Acevedo-Grogues

“…La capacidad inmunoestimuladora de la mayoría de las vacunas es potenciada mediante la adsorción en adyuvantes que contienen aluminio. Variando las condiciones…”
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Repeat-dose and local tolerance toxicity of SARS-CoV-2 FINLAY-FR-02 vaccine candidate in Sprague Dawley rats by Oliva-Hernández, Reynaldo, Fariñas-Medina, Mildrey, Hernández-Salazar, Tamara, Oyarzabal-Vera, Ambar, Infante-Bourzac, Juan F., Rodríguez-Salgueiro, Sandra, Rodríguez-Noda, Laura M., Arranguren-Masorra, Yisabel, Climent-Ruíz, Yanet, Fernández-Castillo, Sonsire, G-Rivera, Daniel, Santana-Mederos, Darielys, Sánchez-Ramírez, Belinda, García-Rivera, Dagmar, Valdés-Barbín, Yury, Vérez-Bencomo, Vicente

“…This study evaluates safety of FINLAY-FR-02, a vaccine candidate against SARS-CoV-2 based on the recombinant receptor binding domain conjugated to tetanus…”
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Open-label phase I/II clinical trial of SARS-CoV-2 receptor binding domain-tetanus toxoid conjugate vaccine (FINLAY-FR-2) in combination with receptor binding domain-protein vaccine (FINLAY-FR-1A) in children by Puga-Gómez, Rinaldo, Ricardo-Delgado, Yariset, Rojas-Iriarte, Chaumey, Céspedes-Henriquez, Leyanis, Piedra-Bello, Misleidys, Vega-Mendoza, Dania, Pérez, Noelvia Pestana, Paredes-Moreno, Beatriz, Rodríguez-González, Meiby, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Rodríguez-Noda, Laura, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Fundora-Barrios, Talía, Echevarría, Martha Dubet, Enriquez-Puertas, Juliet María, Infante-Hernández, Yenicet, Palenzuela-Díaz, Ariel, Gato-Orozco, Evelyn, Chappi-Estévez, Yanet, Francisco-Pérez, Julio Cesar, Suarez-Martinez, Miladi, Castillo-Quintana, Ismavy C., Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, García-Vega, Yanelda, Toledo-Romani, María Eugenia, Doroud, Delaram, Biglari, Alireza, Valdés-Balbín, Yury, García-Rivera, Dagmar, Vérez-Bencomo, Vicente, Mesa-Herrera, María Elena, García-Cristiá, Yarmila, Verdecia-Sánchez, Leonor, del Valle Rodríguez, Rafael, Oquendo-de la Cruz, Yudalvies, Álvarez-Montalvo, Daysi, Grillo-Fortún, Randy, López-González, Liset, Galindo, Omaida Fonte, Reyes-González, Yeseni, González-Álvarez, Ana Beatriz, Gorrita-Mora, Linet, Valera-Fernández, Rodrigo, Ontivero-Pino, Ivis, Martínez-Pérez, Marisel, Caballero-Gonzalez, Esperanza, Garcés-Hechavarría, Aniurka, Martínez-Bedoya, Dayle, Medina-Nápoles, Maite, Domínguez-Pentón, Yeney Regla, Cazañas-Quintana, Yadira, Barrios, Thais Fundora, Fernández, Diana R. Hernández, Bergado-Báez, Gretchen, Orosa-Vazquez, Ivette, Pi-Estopiñan, Franciscary, Díaz-Hernández, Marianniz, Cruz-Sui, Otto, Noa-Romero, Enrique, García-López, Arilia, Muro, Sandra Rivadereira, Baro-Roman, Gerardo

“…•FINLAY-FR-2 conjugate vaccine is safe and immunogenic in children 3-18 years old.•The third dose with FINLAY-FR-1A (dimer receptor binding domain vaccine)…”
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Estandarización de un ELISA para la cuantificación de anticuerpos IgG contra vesículas de membrana externa de Salmonella Paratyphi A by Pérez-Barrios, Yosbany, Aranguren-Mazorra, Yisabel, Zayas-Vignier, Caridad, Blain-Torres, Kirenia, Hernández-Cedeño, Mabel, Rodríguez-Hernández, Yaimara, Álvarez-Tito, Maylin, Nuñez-Martínez, Darcy, González-Aznar, Elizabeth, Soubal-Mora, Jean P, Pérez-Quiñoy, José L, García-Rivera, Dagmar, Fernández-Castillo, Sonsire, Acevedo-Grogues, Reinaldo

“…Salmonella Paratyphi A es un patógeno exclusivo de humanos, siendo la segunda causa más común de fiebre entérica en el sudeste asiático. Recientemente la…”
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Safety and efficacy of the two doses conjugated protein-based SOBERANA-02 COVID-19 vaccine and of a heterologous three-dose combination with SOBERANA-Plus: a double-blind, randomised, placebo-controlled phase 3 clinical trial by Toledo-Romaní, María Eugenia, García-Carmenate, Mayra, Valenzuela-Silva, Carmen, Baldoquín-Rodríguez, Waldemar, Martínez-Pérez, Marisel, Rodríguez-González, Meiby, Paredes-Moreno, Beatriz, Mendoza-Hernández, Ivis, González-Mujica Romero, Raúl, Samón-Tabio, Oscar, Velazco-Villares, Pablo, Bacallao-Castillo, Juan Pablo, Licea-Martín, Ernesto, Rodríguez-Ortega, Misladys, Herrera-Marrero, Nuris, Caballero-González, Esperanza, Egües-Torres, Liudmila, Duartes-González, Reinaldo, García-Blanco, Serguey, Pérez-Cabrera, Suzette, Huete-Ferreira, Santos, Idalmis-Cisnero, Kirenia, Fonte-Galindo, Omayda, Meliá-Pérez, Dania, Rojas-Remedios, Ivonne, Doroud, Delaram, Gouya, Mohammad Mehdi, Biglari, Alireza, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Valdes-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, Verez-Bencomo, Vicente

“…SOBERANA-02 is a COVID-19 conjugate vaccine (recombinant RBD conjugated to tetanus toxoid). Phases 1/2 clinical trials demonstrated high immunogenicity,…”
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Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2–11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population study by Toledo-Romaní, María Eugenia, Valenzuela-Silva, Carmen, Montero-Díaz, Minerva, Iñiguez-Rojas, Luisa, Rodríguez-González, Meiby, Martínez-Cabrera, Mery, Puga-Gómez, Rinaldo, German-Almeida, Angel, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, López-González, Lissette, Morales-Suárez, Ileana, Doroud, Delaram, Valdés-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, Vérez-Bencomo, Vicente

“…Increased pediatric COVID-19 occurrence due to the SARS-CoV-2 Omicron variant has raised concerns about the effectiveness of existing vaccines. The protection…”
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Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2–11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population studyResearch in context by María Eugenia Toledo-Romaní, Carmen Valenzuela-Silva, Minerva Montero-Díaz, Luisa Iñiguez-Rojas, Meiby Rodríguez-González, Mery Martínez-Cabrera, Rinaldo Puga-Gómez, Angel German-Almeida, Sonsire Fernández-Castillo, Yanet Climent-Ruiz, Darielys Santana-Mederos, Lissette López-González, Ileana Morales-Suárez, Delaram Doroud, Yury Valdés-Balbín, Dagmar García-Rivera, Patrick Van der Stuyft, Vicente Vérez-Bencomo

“…Background: Increased pediatric COVID-19 occurrence due to the SARS-CoV-2 Omicron variant has raised concerns about the effectiveness of existing vaccines. The…”
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Safety and efficacy of the two doses conjugated protein-based SOBERANA-02 COVID-19 vaccine and of a heterologous three-dose combination with SOBERANA-Plus: a double-blind, randomised, placebo-controlled phase 3 clinical trialResearch in context by María Eugenia Toledo-Romaní, Mayra García-Carmenate, Carmen Valenzuela-Silva, Waldemar Baldoquín-Rodríguez, Marisel Martínez-Pérez, Meiby Rodríguez-González, Beatriz Paredes-Moreno, Ivis Mendoza-Hernández, Raúl González-Mujica Romero, Oscar Samón-Tabio, Pablo Velazco-Villares, Juan Pablo Bacallao-Castillo, Ernesto Licea-Martín, Misladys Rodríguez-Ortega, Nuris Herrera-Marrero, Esperanza Caballero-González, Liudmila Egües-Torres, Reinaldo Duartes-González, Serguey García-Blanco, Suzette Pérez-Cabrera, Santos Huete-Ferreira, Kirenia Idalmis-Cisnero, Omayda Fonte-Galindo, Dania Meliá-Pérez, Ivonne Rojas-Remedios, Delaram Doroud, Mohammad Mehdi Gouya, Alireza Biglari, Sonsire Fernández-Castillo, Yanet Climent-Ruiz, Yury Valdes-Balbín, Dagmar García-Rivera, Patrick Van der Stuyft, Vicente Verez-Bencomo

“…Background: SOBERANA-02 is a COVID-19 conjugate vaccine (recombinant RBD conjugated to tetanus toxoid). Phases 1/2 clinical trials demonstrated high…”
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Diseño, desarrollo y evaluación preclínica de SOBERANA®02: una vacuna cubana contra COVID-19 by Balbín, Yury Valdés, Mederos, Darielys Santana, Moreno, Lauren María Quintero, Castillo, Sonsire Fernández, Noda, Laura Marta Rodríguez, Ramírez, Belinda Sánchez, Nicado, Rocmira Pérez, Grogues, Claudia Ofelia Acosta, Gómez, Yanira Méndez, Ricardo, Manuel García, García, Tays Hernández, Báez, Gretchen Bergado, Estopiñán, Franciscary Pi, Zayas, Anet Valdés, Portilla, Tania Carmenate, González, Ubel Jesús Ramírez, Hernández, Reynaldo Oliva, Mora, Jean Pierre Soubal, Arteaga, Raine Garrido, Jorge, Felix Cardoso San, Cuervo, Mario Landys Chovel, Rodríguez, Humberto González, Medina, Mildrey Fariñas, Salazar, Tamara Hernández, Puertas, Juliet M. Enríquez, Romero, Enrique Noa, Batista, Anamary Suárez, Rodríguez, Luis Ariel Espinosa, Gómez, Yassel Ramos, López, Luis Javier González, Ruiz, Yanet Climent, Dorantes, Gertrudis Rojas, Hernández, Ernesto Relova, Infante, Yanelys Cabrera, Chang, Sum Lai Lozada, Ayo, Tammy Boggiano, Magaz, Eduardo Ojito, Monzón, Kalet León, Chiodo, Fabrizio, Paquet, Françoise, Serra, Lila Rosa Castellanos, Rivera, Daniel García, Garcia Rivera, Dagmar, Bencomo, Vicente Guillermo Verez

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Generation of a murine monoclonal antibody to capsular polysaccharide Vi from Salmonella Typhi by Fátima Reyes-López, Frank Camacho-Casanova, Oscar Otero-Alfaro, Maribel Cuello-Pérez, Darcy Núñez-Martínez, Sonsire Fernández-Castillo, Luis Guillermo García-Imía

“…The conventional hybridoma technology has enabled the development of monoclonal antibodies (Mabs) against many antigens. Mabs have several applications in the…”
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Synthesis of oligosaccharides from terminal B. pertussis LPS pentasaccharide and definition of the minimal epitope recognized by anti-pertussis antibodies by Chen, Guang-wu, Guo, Lina, Huang, Jiasheng, Ma, Haijun, Fernandez-Castillo, Sonsire, Soubal-Mora, Jean Pierre, Valdes-Balbin, Yury, Verez-Bencomo, Vicente

“…Pertussis vaccines have been very effective in controlling whooping-cough epidemics but are ineffective in controlling circulation in older children and…”
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Evaluación preclínica y clínica de SOBERANA® 01. Candidato vacunal contra la COVID-19 by Climent Ruiz, Yanet, Santana Mederos, Darielys, PérezRodríguez, Sonia, Rodríguez González, Meiby de la Caridad, García Rivera, Dagmar, Sánchez Ramírez, Belinda, Valdés Balbín, Yury, Vérez Bencomo, Vicente, Rodríguez Noda, Laura M., Pérez Nicado, Rocmira, Ochoa Azze, Rolando, Boggiano Ayo, Tammy, Valenzuela Silva, Carmen María, González Rodríguez, Humberto, Ramírez González, Ubel J., Paredes Moreno, Beatriz, García Rivera, Daniel, Labrada Regalado, Claudia, Hernández García, Tays, Noa Romero, Enrique, Díaz Hernández, Marianniz, OrosaVázquez, Ivette, BergadoBáez, Gretchen, Pi Estopiñán, Franciscary, Hernández Salazar, Tamara, Fariñas Medina, Mildrey, Enriquez Puertas, Juliet María, González Sosa, Nibaldo Luis, González Delgado, Carlos A., Rubino Moreno, Jorman, Díaz Machado, Alina, González Freire, Yunior, Esmoris Mena, Yudisleidy, Rosales Gil, Lilia Beatríz, Chappi Estévez, Yanet, Amoroto Roig, Mayté, Martínez Pérez, Marisel, Ontiveiro Pino, Ivis, Landys Chovel Cuervo, Mario, Garrido Arteaga, Raine, Cardoso San Jorge, Félix, González Mugica Romero, Raúl, Fernández Castillo, Sonsire, Ojito Magaz, Eduardo, Chiodo, Fabrizio, Paquet, Francoise, Fang, Cheng, Guang-Wu, Chen

“…RESUMEN Introducción: SOBERANA® 01 se desarrolló en el Instituto Finlay de Vacunas para el enfrentamiento a la epidemia causada por el virus SARS-CoV-2. Este…”
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Obtaining of a rapid diagnostic test for Cholera, based on latex particles coupled with a monoclonal antibody against Vibrio cholera O1 lipopolysaccharide by Fátima Reyes-López, Frank Camacho-Casanova, Giovanni Duranti, Marta María Morales-Leslie, Regla Zenaida Mora-Guerra, Sonsire Fernández-Castillo, Elisabeth González-Aznar, Claudio Piermatte, Daniel Tomás Cardoso-González, Luis Guillermo García-Imías

“…Cholera is an acute contagious intestinal disease caused by ingestion of food or water contaminated with O1 and O139 serotypes of the bacterium Vibrio…”
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Safety and immunogenicity of anti-SARS CoV-2 vaccine SOBERANA 02 in homologous or heterologous scheme: Open label phase I and phase IIa clinical trials by Eugenia-Toledo-Romaní, María, Verdecia-Sánchez, Leslyhana, Rodríguez-González, Meiby, Rodríguez-Noda, Laura, Valenzuela-Silva, Carmen, Paredes-Moreno, Beatriz, Sánchez-Ramírez, Belinda, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Bergado-Baez, Gretchen, Pi-Estopiñán, Franciscary, Cruz-Sui, Otto, Fraga-Quintero, Anitza, García-Montero, Majela, Palenzuela-Díaz, Ariel, Baró-Román, Gerardo, Mendoza-Hernández, Ivis, Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, Ramírez Gonzalez, Ubel, García-Vega, Yanelda, Pérez-Massón, Beatriz, Guang-Wu-Chen, Boggiano-Ayo, Tammy, Ojito-Magaz, Eduardo, Rivera, Daniel G., Valdés-Balbín, Yury, García-Rivera, Dagmar, Vérez-Bencomo, Vicente, Gómez-Maceo, Yanet, Reyes-Matienzo, Radamet, Manuel Coviella-Artime, José, Morffi-Cinta, Irania, Martínez-Pérez, Marisel, Castillo-Quintana, Ismavy, Garcés-Hechavarría, Aniurka, Valera-Fernández, Rodrigo, Martínez-Bedoya, Dayle, Garrido-Arteaga, Raine, Cardoso-SanJorge, Félix, Quintero Moreno, Lauren, Ontivero-Pino, Ivis, Teresa Pérez-Guevara, María, Morales-García, Marilin, Noa-Romero, Enrique, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, Rojas, Gertrudis, Tundidor, Yaima, García-López, Elena, Muñoz-Morejon, Yaima, Galano-Frutos, Evelyn, Rodríguez-Alvarez, Julián, Arteaga, Amaylid, Medina Nápoles, Maite, Espi Ávila, Jennifer, Fontanies Fernández, Marcos

“…SOBERANA 02 is a COVID-19 vaccine based on SARS-CoV-2 recombinant RBD conjugated to tetanus toxoid (TT). SOBERANA Plus antigen is dimeric-RBD. Here we report…”
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Advances in the characterization of a proteol iposome derived from Mycobacterium bovis BCG as vaccine candidate against tuberculosis by Nadine Alvarez-Cabrera, Sonsire Fernández-Castillo, Daymí Serpa-Almaguer, Daily Serrano-Hernández, Caridad Zayas-Vignier, Rubén Adonis Cabrera-Arias, Reinaldo Acevedo-Grogues, Vladimir Peña-Sánchez, Norazmi Mohd-Nor, María Elena Sarmiento-García-San Miguel, Armando Acosta-Domínguez, José Luis Pérez- Quiñoy

“…Despite efforts to eradicate tuberculosis (TB) worldwide, this remains a serious health problem. The Bacillus Calmette-Guerin (BCG), the only available vaccine…”
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Obtención de un anticuerpo monoclonal murino que reconoce al polisacárido capsular Vi de Salmonella Typhi by Amin-Blanco, Nevis, Reyes-López, Fátima, Camacho-Casanova, Frank, Otero-Alfaro, Oscar, Cuello-Pérez, Maribel, Núñez-Martínez, Darcy, Fernández-Castillo, Sonsire, García-Imía, Luis Guillermo

“…La tecnología clásica del hibridoma permitió el desarrollo de anticuerpos monoclonales (AcM) contra una inmensa variedad de antígenos, los cuales tienen…”
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