Search Results - "Sonoyama, Takuhiro"

Phase 1/2 clinical trial of COVID-19 vaccine in Japanese participants: A report of interim findings by Iwata, Satoshi, Sonoyama, Takuhiro, Kamitani, Akari, Shibata, Risa, Homma, Tomoyuki, Omoto, Shinya, Igarashi, Kenji, Ariyasu, Mari

“…•Domestic COVID-19 vaccines in Japan are needed.•Interim findings from a phase 1/2 trial in Japan are presented.•S-268019-b vaccine is safe, well tolerated,…”
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Leptin-Mediated Changes in the Human Metabolome by Lawler, Katherine, Huang-Doran, Isabel, Sonoyama, Takuhiro, Collet, Tinh-Hai, Keogh, Julia M, Henning, Elana, O’Rahilly, Stephen, Bottolo, Leonardo, Farooqi, I Sadaf

“…Abstract Context While severe obesity due to congenital leptin deficiency is rare, studies in patients before and after treatment with leptin can provide…”
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Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity by MIYASHITA, Kazutoshi, ITOH, Hiroshi, NAKAO, Kazuwa, TSUJIMOTO, Hirokazu, TAMURA, Naohisa, FUKUNAGA, Yasutomo, SONE, Masakatsu, YAMAHARA, Kenichi, TAURA, Daisuke, INUZUKA, Megumi, SONOYAMA, Takuhiro

“…Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity Kazutoshi Miyashita 1 , Hiroshi…”
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Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities by Sonoyama, Takuhiro, Stadler, Lukas K. J., Zhu, Mingyan, Keogh, Julia M., Henning, Elana, Hisama, Fuki, Kirwan, Peter, Jura, Magdalena, Blaszczyk, Beata K., DeWitt, David C., Brouwers, Bas, Hyvönen, Marko, Barroso, Inês, Merkle, Florian T., Appleyard, Suzanne M., Wayman, Gary A., Farooqi, I. Sadaf

“…Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development,…”
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A phase 3 randomized controlled trial of a COVID-19 recombinant vaccine S-268019-b versus ChAdOx1 nCoV-19 in Japanese adults by Iwata, Satoshi, Pollard, Andrew J., Tada, Yukio, Omoto, Shinya, Shibata, Risa Y., Igarashi, Kenji, Hasegawa, Takahiro, Ariyasu, Mari, Sonoyama, Takuhiro

“…We assessed S-268019-b, a recombinant spike protein vaccine with a squalene-based adjuvant, for superiority in its immunogenicity over ChAdOx1 nCoV-19 vaccine…”
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Open-label study of the safety, pharmacokinetics, and effectiveness of a 2 mg/kg dose of baloxavir marboxil 2% granules in children <20 kg with influenza by Sonoyama, Takuhiro, Sakaguchi, Hiroki, Koshimichi, Hiroki, Noshi, Takeshi, Tsuchiya, Kenji, Uehara, Takeki

“…Baloxavir marboxil is an oral anti-influenza drug with demonstrated safety and efficacy in pediatric patients when a 2% granules formulation is administered at…”
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Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice by Homma, Tomoyuki, Nagata, Noriyo, Hashimoto, Masayuki, Iwata-Yoshikawa, Naoko, Seki, Naomi M., Shiwa-Sudo, Nozomi, Ainai, Akira, Dohi, Keiji, Nikaido, Eiji, Mukai, Akiko, Ukai, Yuuta, Nakagawa, Takayuki, Shimo, Yusuke, Maeda, Hiroki, Shirai, Seiki, Aoki, Miwa, Sonoyama, Takuhiro, Sato, Mamoru, Fumoto, Masataka, Nagira, Morio, Nakata, Fumihisa, Hashiguchi, Takao, Suzuki, Tadaki, Omoto, Shinya, Hasegawa, Hideki

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Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice by Homma, Tomoyuki, Nagata, Noriyo, Hashimoto, Masayuki, Iwata-Yoshikawa, Naoko, Seki, Naomi M., Shiwa-Sudo, Nozomi, Ainai, Akira, Dohi, Keiji, Nikaido, Eiji, Mukai, Akiko, Ukai, Yuuta, Nakagawa, Takayuki, Shimo, Yusuke, Maeda, Hiroki, Shirai, Seiki, Aoki, Miwa, Sonoyama, Takuhiro, Sato, Mamoru, Fumoto, Masataka, Nagira, Morio, Nakata, Fumihisa, Hashiguchi, Takao, Suzuki, Tadaki, Omoto, Shinya, Hasegawa, Hideki

“…Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease (COVID-19), are…”
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Pharmacokinetics, safety, and tolerability of single and multiple doses of zuranolone in Japanese and White healthy subjects: A phase 1 clinical trial by Sonoyama, Takuhiro, Shimizu, Ryosuke, Kubota, Ryuji, Matsuo, Yumiko, Okutsu, Daiki, Yamanaka, Hideki, Takasu, Keiko, Ogawa, Koichi, Motomiya, Tomoko

“…Aim This phase 1 study assessed the pharmacokinetics, safety, and tolerability of zuranolone in Japanese and White healthy adults, and Japanese healthy elderly…”
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Safety and immunogenicity of a booster dose of S-268019-b: Interim findings of a Phase 3, open-label clinical study in Japan by Sonoyama, Takuhiro, Kamitani, Akari, Shibata, Risa Y., Seki, Naomi M., Omoto, Shinya, Igarashi, Kenji, Ariyasu, Mari

“…•S-268019-b is a protein-based subunit vaccine with a squalene-based adjuvant.•Japanese adults and elderly with prior mRNA vaccination received S-268019-b…”
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Significance of Adrenocorticotropin Stimulation Test in the Diagnosis of an Aldosterone-Producing Adenoma by Sonoyama, Takuhiro, Sone, Masakatsu, Miyashita, Kazutoshi, Tamura, Naohisa, Yamahara, Kenichi, Park, Kwijun, Oyamada, Naofumi, Taura, Daisuke, Inuzuka, Megumi, Kojima, Katsutoshi, Honda, Kyoko, Fukunaga, Yasutomo, Kanamoto, Naotetsu, Miura, Masako, Yasoda, Akihiro, Arai, Hiroshi, Itoh, Hiroshi, Nakao, Kazuwa

“…Context: Adrenal venous sampling is the “gold standard” test in the diagnosis of an aldosterone-producing adenoma (APA) among patients with primary…”
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Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells by Homma, Koichiro, Sone, Masakatsu, Taura, Daisuke, Yamahara, Kenichi, Suzuki, Yutaka, Takahashi, Kazutoshi, Sonoyama, Takuhiro, Inuzuka, Megumi, Fukunaga, Yasutomo, Tamura, Naohisa, Itoh, Hiroshi, Yamanaka, Shinya, Nakao, Kazuwa

“…Abstract Objective We previously succeeded in inducing and isolating vascular endothelial cells (ECs) from both human embryonic stem (ES) and induced…”
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The Role of Mineralocorticoid Receptor Expression in Brain Remodeling after Cerebral Ischemia by Oyamada, Naofumi, Sone, Masakatsu, Miyashita, Kazutoshi, Park, Kwijun, Taura, Daisuke, Inuzuka, Megumi, Sonoyama, Takuhiro, Tsujimoto, Hirokazu, Fukunaga, Yasutomo, Tamura, Naohisa, Itoh, Hiroshi, Nakao, Kazuwa

“…Mineralocorticoid receptors (MRs) are classically known to be expressed in the distal collecting duct of the kidney. Recently it was reported that MR is…”
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C-Type Natriuretic Peptide as a New Regulator of Food Intake and Energy Expenditure by Inuzuka, Megumi, Tamura, Naohisa, Yamada, Nobuko, Katsuura, Goro, Oyamada, Naofumi, Taura, Daisuke, Sonoyama, Takuhiro, Fukunaga, Yasutomo, Ohinata, Kousaku, Sone, Masakatsu, Nakao, Kazuwa

“…The physiological implication of C-type natriuretic peptide (CNP) including energy metabolism has not been elucidated, because of markedly short stature in…”
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Transplantation of vascular cells derived from human embryonic stem cells contributes to vascular regeneration after stroke in mice by Oyamada, Naofumi, Itoh, Hiroshi, Sone, Masakatsu, Yamahara, Kenichi, Miyashita, Kazutoshi, Park, Kwijun, Taura, Daisuke, Inuzuka, Megumi, Sonoyama, Takuhiro, Tsujimoto, Hirokazu, Fukunaga, Yasutomo, Tamura, Naohisa, Nakao, Kazuwa

“…We previously demonstrated that vascular endothelial growth factor receptor type 2 (VEGF-R2)-positive cells induced from mouse embryonic stem (ES) cells can…”
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Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide by Sonoyama, Takuhiro, Tamura, Naohisa, Miyashita, Kazutoshi, Park, Kwijun, Oyamada, Naofumi, Taura, Daisuke, Inuzuka, Megumi, Fukunaga, Yasutomo, Sone, Masakatsu, Nakao, Kazuwa

“…Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined…”
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Therapeutic Potential of Atrial Natriuretic Peptide Administration on Peripheral Arterial Diseases by Park, Kwijun, Itoh, Hiroshi, Yamahara, Kenichi, Sone, Masakatsu, Miyashita, Kazutoshi, Oyamada, Naofumi, Sawada, Naoya, Taura, Daisuke, Inuzuka, Megumi, Sonoyama, Takuhiro, Tsujimoto, Hirokazu, Fukunaga, Yasutomo, Tamura, Naohisa, Nakao, Kazuwa

“…Peripheral arterial diseases are caused by arterial sclerosis and impaired collateral vessel formation, which are exacerbated by diabetes, often leading to leg…”
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A Case of Myelolipoma with Bilateral Adrenal Hyperaldosteronism Cured after Unilateral Adrenalectomy by Inuzuka, Megumi, Tamura, Naohisa, Sone, Masakatsu, Taura, Daisuke, Sonoyama, Takuhiro, Honda, Kyoko, Kojima, Katsutoshi, Fukuda, Yorihide, Ueda, Yoriko, Yamashita, Yui, Kondo, Eri, Yamada, Go, Fujii, Toshihito, Miura, Masako, Kanamoto, Naotetsu, Yasoda, Akihiro, Arai, Hiroshi, Mikami, Yoshiki, Sasano, Hironobu, Nakao, Kazuwa

“…Myelolipomas are adrenal tumors composed of both adipose and hematopoietic tissues which are rarely associated with primary aldosteronism (PA). Here, we report…”
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Treatment with ensitrelvir for COVID-19 in hospitalized patients of very advanced age: Case series by Tomita, Takafumi, Miyazawa, Shogo, Sonoyama, Takuhiro

“…Ensitrelvir fumaric acid (ensitrelvir) is an orally active 3C-like protease inhibitor used to treat severe acute respiratory syndrome coronavirus 2 infection…”
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Safety, Tolerability, and Pharmacokinetics of the Novel Antiviral Agent Ensitrelvir Fumaric Acid, a SARS-CoV-2 3CL Protease Inhibitor, in Healthy Adults by Shimizu, Ryosuke, Sonoyama, Takuhiro, Fukuhara, Takahiro, Kuwata, Aya, Matsuo, Yumiko, Kubota, Ryuji

“…Ensitrelvir is a novel selective inhibitor of the 3C-like protease of SARS-CoV-2, which is essential for viral replication. This phase 1 study of ensitrelvir…”
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