Search Results - "Sonkar, Vijay K."

Mitochondrial ATP generation in stimulated platelets is essential for granule secretion but dispensable for aggregation and procoagulant activity by Kulkarni, Paresh P, Ekhlak, Mohammad, Sonkar, Vijay K, Dash, Debabrata

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Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents by Kulkarni, Paresh P, Tiwari, Arundhati, Singh, Nitesh, Gautam, Deepa, Sonkar, Vijay K, Agarwal, Vikas, Dash, Debabrata

“…Platelets are critical to arterial thrombosis, which underlies myocardial infarction and stroke. Activated platelets, regardless of the nature of their…”
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DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross-Sectional Study in Mice and Humans by Kumar, Rahul, Sonkar, Vijay K, Swamy, Jagadish, Ahmed, Azaj, Sharathkumar, Anjali A, Pierce, Gary L, Dayal, Sanjana

“…Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces…”
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Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia by Gu, Sean X, Sonkar, Vijay K, Katare, Parmeshwar B, Kumar, Rahul, Kruger, Warren D, Arning, Erland, Bottiglieri, Teodoro, Lentz, Steven R, Dayal, Sanjana

“…Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding…”
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Staphylococcal β-Toxin Modulates Human Aortic Endothelial Cell and Platelet Function through Sphingomyelinase and Biofilm Ligase Activities by Herrera, Alfa, Kulhankova, Katarina, Sonkar, Vijay K, Dayal, Sanjana, Klingelhutz, Aloysius J, Salgado-Pabón, Wilmara, Schlievert, Patrick M

“…causes many infections, such as skin and soft tissue, pneumonia, osteomyelitis, and infective endocarditis (IE). IE is an endovascular infection of native and…”
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Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis by Nayak, Manasa K., Dhanesha, Nirav, Doddapattar, Prakash, Rodriguez, Omar, Sonkar, Vijay K., Dayal, Sanjana, Chauhan, Anil K.

“…Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) to generate…”
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Correction to: Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity by Sonkar, Vijay K, Kulkarni, Paresh P, Chaurasia, Susheel N, Dash, Ayusman, Jauhari, Abhishek, Parmar, Devendra, Yadav, Sanjay, Dash, Debabrata

“…Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows…”
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Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity by Sonkar, Vijay K, Kulkarni, Paresh P, Chaurasia, Susheel N, Dash, Ayusman, Jauhari, Abhishek, Parmar, Devendra, Yadav, Sanjay, Dash, Debabrata

“…Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterized by extensive loss of neurons and deposition of amyloid β (Aβ) in the form…”
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Amine-Modified Graphene: Thrombo-Protective Safer Alternative to Graphene Oxide for Biomedical Applications by Singh, Sunil K, Singh, Manoj K, Kulkarni, Paresh P, Sonkar, Vijay K, Grácio, José J. A, Dash, Debabrata

“…Graphene and its derivatives have attracted significant research interest based on their application potential in different fields including biomedicine…”
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Amyloid β peptide stimulates platelet activation through RhoA‐dependent modulation of actomyosin organization by Sonkar, Vijay K., Kulkarni, Paresh P., Dash, Debabrata

“…Platelets contribute to 95% of circulating amyloid precursor protein in the body and have widely been employed as a “peripheral” model of neurons in…”
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AMPK inhibition protects against arterial thrombosis while sparing hemostasis through differential modulation of platelet responses by Kulkarni, Paresh P., Sonkar, Vijay K., Gautam, Deepa, Dash, Debabrata

“…AMP-activated protein kinase (AMPK) is a metabolic master switch that has critical role in wide range of pathologies including cardiovascular disorders. As…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

“…Reactive oxygen species (ROS) contribute to platelet hyperactivation during aging. Several oxidative pathways and antioxidant enzymes have been implicated;…”
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Letter by Sonkar et al Regarding Article, “Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase” by Sonkar, Vijay K, Lentz, Steven R, Dayal, Sanjana

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Prion protein fragment (106–126) induces prothrombotic state by raising platelet intracellular calcium and microparticle release by Mallick, Ram L, Kumari, Sharda, Singh, Nitesh, Sonkar, Vijay K, Dash, Debabrata

“…Highlights • PrP(106–126) induces platelet activation rise. • PrP(106–126) induces rise in [Ca2+ ] i in platelets. • PrP(106–126) stimulates calpain activity…”
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Noncanonical Sonic Hedgehog signaling amplifies platelet reactivity and thrombogenicity by Tiwari, Arundhati, Gautam, Deepa, Kulkarni, Paresh P., Ekhlak, Mohammad, Sonkar, Vijay K., Agrawal, Vikas, Dash, Debabrata

“…Sonic Hedgehog (Shh) is a morphogen in vertebrate embryos that is also associated with organ homeostasis in adults. We report here that human platelets, though…”
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Nox2 NADPH oxidase is dispensable for platelet activation or arterial thrombosis in mice by Sonkar, Vijay K., Kumar, Rahul, Jensen, Melissa, Wagner, Brett A., Sharathkumar, Anjali A., Miller, Francis J., Fasano, MaryBeth, Lentz, Steven R., Buettner, Garry R., Dayal, Sanjana

“…Deficiency of the Nox2 (gp91phox) catalytic subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a genetic cause of X-linked chronic…”
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Loss of endogenous Nox2-NADPH oxidase does not prevent age-induced platelet activation and arterial thrombosis in mice by Ahmed, Azaj, Patil, Gokul, Sonkar, Vijay K., Jensen, Melissa, Streeter, Jennifer, Dayal, Sanjana

“…Reactive oxygen species are known to contribute to platelet hyperactivation and thrombosis during aging; however, the mechanistic contribution of the specific…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

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Abstract 305: Genetic Deficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in Mice by Sonkar, Vijay K, Kumar, Rahul, Gu, Sean, Doddapattar, Prakash, Lentz, Steven R, Dayal, Sanjana

“…Abstract only Activated neutrophils release neutrophil extracellular traps (NETs) via a pathway dependent on reactive oxygen species (ROS). NETs are enriched…”
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Abstract 054: Genetic Deficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in Mice by Sonkar, Vijay K, Kumar, Rahul, Gu, Sean, Doddapattar, Prakash, Lentz, Steven R, Dayal, Sanjana

“…Abstract only Activated neutrophils release neutrophil extracellular traps (NETs) via a pathway dependent on reactive oxygen species (ROS). NETs are enriched…”
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