Search Results - "Soni, Sanooj"
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Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients
Published in PloS one (01-07-2022)“…A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing…”
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Microvesicle-Mediated Communication Within the Alveolar Space: Mechanisms of Uptake by Epithelial Cells and Alveolar Macrophages
Published in Frontiers in immunology (27-04-2022)“…Intra-alveolar microvesicles (MVs) are important mediators of inter-cellular communication within the alveolar space, and are key components in the…”
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Monocytes mediate homing of circulating microvesicles to the pulmonary vasculature during low-grade systemic inflammation
Published in Journal of extracellular vesicles (01-01-2020)“…Microvesicles (MVs), a plasma membrane-derived subclass of extracellular vesicles, are produced and released into the circulation during systemic inflammation,…”
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Alveolar macrophage-derived microvesicles mediate acute lung injury
Published in Thorax (01-11-2016)“…Microvesicles (MVs) are important mediators of intercellular communication, packaging a variety of molecular cargo. They have been implicated in the…”
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Conservative versus Liberal Oxygen Therapy
Published in American journal of respiratory and critical care medicine (15-06-2022)“…Watson discusses the study by D. Mackle and colleagues on conservative oxygen therapy during mechanical ventilation in the intensive care unit (ICU). The…”
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ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles
Published in The FASEB journal (01-05-2019)“…ABSTRACTCellular stress or injury induces release of endogenous danger signals such as ATP, which plays a central role in activating immune cells. ATP is…”
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Recommended Reading from the Imperial College, London Fellows
Published in American journal of respiratory and critical care medicine (02-05-2022)Get full text
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Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity
Published in American journal of respiratory cell and molecular biology (01-07-2024)“…Mechanical ventilation contributes to the morbidity and mortality of patients in intensive care, likely through the exacerbation and dissemination of…”
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One hundred eighteen days on a ventilator: a COVID-19 success story against all odds
Published in BMJ case reports (29-03-2021)“…Emerging data suggest that patients with certain comorbidities requiring intensive care unit (ICU) admission for COVID-19 have a poor prognosis. This report…”
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Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD
Published in American journal of physiology. Lung cellular and molecular physiology (01-01-2021)“…Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack of biochemical markers to aid clinical…”
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Secreted Extracellular Cyclophilin A Is a Novel Mediator of Ventilator-induced Lung Injury
Published in American journal of respiratory and critical care medicine (15-08-2021)“…Mechanical ventilation is a mainstay of intensive care but contributes to the mortality of patients through ventilator-induced lung injury. eCypA…”
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Ventilation following established ARDS: a preclinical model framework to improve predictive power
Published in Thorax (01-12-2019)“…Despite advances in understanding the pathophysiology of acute respiratory distress syndrome, effective pharmacological interventions have proven elusive. We…”
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Enhanced Recognition and Internalisation of Microvesicles by Lung‐Marginated, Ly‐6C high Monocytes During Endotoxaemia
Published in The FASEB journal (01-04-2017)“…Background Circulating microvesicles (MVs) have been implicated as long‐range mediators of vascular inflammation, but their precise role in the pathophysiology…”
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Microvesicles as new therapeutic targets for the treatment of the acute respiratory distress syndrome (ARDS)
Published in Expert opinion on therapeutic targets (02-11-2019)“…: Acute respiratory distress syndrome (ARDS) is a heterogeneous and multifactorial disease; it is a common and devastating condition that has a high mortality…”
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Microvesicles are key mediators of inflammation in acute lung injury
Published 01-01-2018“…Acute lung injury (ALI) and its clinical presentation Acute Respiratory Distress Syndrome (ARDS) has an unacceptably high mortality, surpassing 40% in those…”
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Flecainide overdose causing a Brugada-type pattern on electrocardiogram in a previously well patient
Published in The American journal of emergency medicine (01-03-2009)“…Since its definition in 1992, Brugada syndrome has been identified as the most common cause of natural death in men younger than 50 years in parts of Asia…”
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