Search Results - "Songyang, Z."

TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression by Jiang, C, Zhu, Y, Zhou, Z, Gumin, J, Bengtsson, L, Wu, W, Songyang, Z, Lang, F F, Lin, X

“…Epidermal growth factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and survival. Overexpression and mutations of…”
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Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains by Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., Cantley, L. C.

“…The oriented peptide library technique was used to investigate the peptide-binding specificities of nine PDZ domains. Each PDZ domain selected peptides with…”
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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 by Songyang, Z., Lu, Kun Ping, Kwon, Young T., Tsai, Li-Huei, Filhol, Odile, Cochet, Claude, Brickey, Debra A., Soderling, Thomas R., Bartleson, Cheryl, Graves, Donald J., DeMaggio, Anthony J., Hoekstra, Merl F., Blenis, John, Hunter, Tony, Cantley, Lewis C.

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CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling by Zheng, Z-Y, Cheng, C-M, Fu, X-R, Chen, L-Y, Xu, L, Terrillon, S, Wong, S T, Bar-Sagi, D, Songyang, Z, Chang, E C

“…While Ras is well-known to function on the plasma membrane (PM) to mediate growth factor signaling, increasing evidence suggests that Ras has complex roles in…”
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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav by SONGYANG, Z, SHOELSON, S. E, REN, R, BALTIMORE, D, RATNOFSKY, S, FELDMAN, R. A, CANTLEY, L. C, MCGLADE, J, OLIVIER, P, PAWSON, T, BUSTELO, X. R, BARBACID, M, SABE, H, HANAFUSA, H, YI, T

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Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes by Boll, W., Ohno, H., Songyang, Z., Rapoport, I., Cantley, L. C., Bonifacino, J. S., Kirchhausen, T.

“…We recently determined that fusion proteins containing tyrosine‐based endocytic signals bind to the mu 2 subunit of AP‐2, the complex that drives clathrin coat…”
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Structural Basis of Membrane Targeting by the Phox Homology Domain of Cytokine-independent Survival Kinase (CISK-PX) by Xing, Yi, Liu, Dan, Zhang, Rongguang, Joachimiak, Andrzej, Songyang, Zhou, Xu, Wenqing

“…The cytokine-independent survival kinase (CISK) in the serum and glucocorticoid-regulated kinase family plays an important role in mediating cell growth and…”
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The use of peptide library for the determination of kinase peptide substrates by Songyang, Z, Cantley, L C

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The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif (∗) by Songyang, Zhou, Margolis, Benjamin, Chaudhuri, Manas, Shoelson, Steve E., Cantley, Lewis C.

“…Reversible assembly of intracellular signaling complexes is, in some cases, mediated by direct binding of a Src homology 2 (SH2) domain of one protein to a…”
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Analysis of protein kinase specificity by peptide libraries and prediction of in vivo substrates by Songyang, Z

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Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts by Birge, R B, Fajardo, J E, Reichman, C, Shoelson, S E, Songyang, Z, Cantley, L C, Hanafusa, H

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A Mammalian Adaptor Protein with Conserved Src Homology 2 and Phosphotyrosine-Binding Domains is Related to Shc and is Specifically Expressed in the Brain by O'Bryan, John P., Songyang, Zhou, Cantley, Lewis, Der, Channing J., Pawson, Tony

“…The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain…”
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Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes by Boll, W., Ohno, H., Songyang, Z., Rapoport, I., Cantley, L. C., Bonifacino, J. S., Kirchhausen, T.

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Genetic screens in mammalian cells by enhanced retroviral mutagens by LIU, Dan, XIAOHONG YANG, DONGLIANG YANG, ZHOU SONGYANG

“…Genetic approaches such as retrovirus-mediated mutagenesis and cDNA expression libraries have contributed greatly to our understanding of signal transduction…”
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Peptide library screening for determination of SH2 or phosphotyrosine-binding domain sequences by Songyang, Z, Liu, D

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NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK by Xia, Xiaojun, Cui, Jun, Wang, Helen Y., Zhu, Liang, Matsueda, Satoko, Wang, Qinfu, Yang, Xiaoang, Hong, Jun, Songyang, Zhou, Chen, Zhijian J., Wang, Rong-Fu

“…Tight regulation of NF-κB signaling is essential for innate and adaptive immune responses, yet the molecular mechanisms responsible for its negative regulation…”
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Specificity in recognition of phosphopeptides by src-homology 2 domains by Cantley, L C, Songyang, Z

“…SH2 domains and SH3 domains, found in a number of protein-tyrosine kinases and substrates of protein-tyrosine kinases, provide specificity in downstream…”
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Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins by Liu, Dan, O'Connor, Matthew S., Qin, Jun, Songyang, Zhou

“…In mammalian cells, telomere-binding proteins TRF1 and TRF2 play crucial roles in telomere biology. They interact with several other telomere regulators…”
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TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-[kappa]B activation and tumor progression by Jiang, C, Zhu, Y, Zhou, Z, Gumin, J, Bengtsson, L, Wu, W, Songyang, Z, Lang, F F, Lin, X

“…Epidermal growth factor receptor (EGFR) family members play pivotal roles in cell proliferation, differentiation and survival. Overexpression and mutations of…”
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Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity by Yoakim, M, Hou, W, Songyang, Z, Liu, Y, Cantley, L, Schaffhausen, B

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