Anti-inflammation Study of Cellulose-Chitosan Biocomposite-Based Tetrapleura tetraptera (Taub) Dried Fruits Aqueous Extract

Nanotechnology is making exceptional progress in the medical field. The development of new systems for the delivery of plant ingredients brings benefits such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocompos...

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Bibliographic Details
Published in:	BioNanoScience Vol. 14; no. 2; pp. 699 - 709
Main Authors:	Hzounda Fokou, Jean Baptiste, Nsegbe, Annick Christianne, Beglau, Thi Hai Yen, Fetzer, Marcus N. A., Mbogbe, Elise Nadia, Chameni Nkouankam, Jenna Maeva, Ngadie Mponge, Pamela, Ngo Yomkil Baleng, Marie Tryphene Magaly, Songue, Sylvie Pascale, Ninpa Kuissi, Chris Rosaire, Koube, Juliette, Sone Enone, Bertin, Ntoumba, Agnes Antoinette, Eya’ane Meva, Francois, Janiak, Christoph
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-06-2024
Subjects:	Biological and Medical Physics Biomaterials Biophysics Circuits and Systems Engineering Nanotechnology Nanocomposite Fruit Anti-inflammatory Acute toxicity
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Summary:	Nanotechnology is making exceptional progress in the medical field. The development of new systems for the delivery of plant ingredients brings benefits such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocomposites from Tetrapleura tetraptera despite its wide range of ethnopharmacological uses including management of inflammatory diseases. This study aimed to prepare chitosan- and cellulose-based nanocomposites with anti-inflammatory potential. The biocomposites showed an encapsulation efficiency of 69.4%. Their formation was confirmed by a peak at 290 nm in UV–Vis. Infrared spectrophotometry proved the formation of a mixed polysaccharide and polyphenol system. No signs of toxicity and no deaths were found; therefore, the lethal dose 50 (LD 50 ) is higher than 2000 mg/kg. The biocomposite has an anti-inflammatory activity in vitro with a maximum inhibition of 99.5% and an anti-inflammatory activity in vivo with a maximum inhibition of 98.7% for a dose of 200 mg/kg. The synthesized biocomposites from the aqueous extract of the fruits of Tetrapleura tetraptera showed an anti-inflammatory property with satisfactory safety.
ISSN:	2191-1630 2191-1649
DOI:	10.1007/s12668-024-01364-6