Search Results - "Song, Zhiyin"

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis by Yan, Chaojun, Gong, Longlong, Chen, Li, Xu, Meng, Abou-Hamdan, Hussein, Tang, Mingliang, Désaubry, Laurent, Song, Zhiyin

“…Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, is critical for mitochondrial quality control and…”
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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission by Losón, Oliver C, Song, Zhiyin, Chen, Hsiuchen, Chan, David C

“…Several mitochondrial outer membrane proteins-mitochondrial fission protein 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics proteins of 49…”
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Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact by Tang, Junhui, Zhang, Kuan, Dong, Jun, Yan, Chaojun, Hu, Chao, Ji, Hongchao, Chen, Liangyi, Chen, Shi, Zhao, Huabin, Song, Zhiyin

“…Mitochondrial cristae are critical for efficient oxidative phosphorylation, however, how cristae architecture is precisely organized remains largely unknown…”
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Mitochondrial DNA: Distribution, Mutations, and Elimination by Yan, Chaojun, Duanmu, Xiaoying, Zeng, Ling, Liu, Bing, Song, Zhiyin

“…Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is…”
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Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury by Chen, Li, Dong, Jun, Liao, Siyang, Wang, Siyou, Wu, Zhida, Zuo, Meiling, Liu, Bing, Yan, Chaojun, Chen, Yong, He, He, Meng, Qingtao, Song, Zhiyin

“…Background and Aims Sam50, a key component of the sorting and assembly machinery (SAM) complex, is also involved in bridging mitochondrial outer‐membrane and…”
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OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L by Song, Zhiyin, Chen, Hsiuchen, Fiket, Maja, Alexander, Christiane, Chan, David C

“…OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the…”
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Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion by Song, Zhiyin, Ghochani, Mariam, McCaffery, J Michael, Frey, Terrence G, Chan, David C

“…Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases--OPA1 and the mitofusins Mfn1 and Mfn2--are…”
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A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 by Yue, Wen, Chen, Ziheng, Liu, Haiyang, Yan, Chen, Chen, Ming, Feng, Du, Yan, Chaojun, Wu, Hao, Du, Lei, Wang, Yueying, Liu, Jinhua, Huang, Xiaohu, Xia, Laixin, Liu, Lei, Wang, Xiaohui, Jin, Haijing, Wang, Jun, Song, Zhiyin, Hao, Xiaojiang, Chen, Quan

“…Mitocbondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial compartment for normal mitochondrial functions and mitochondrial…”
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Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion by Hao, Tianshu, Yu, Jianglong, Wu, Zhida, Jiang, Jie, Gong, Longlong, Wang, Bingjun, Guo, Hanze, Zhao, Huabin, Lu, Bin, Engelender, Simone, He, He, Song, Zhiyin

“…Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes…”
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OPA1 and MICOS Regulate mitochondrial crista dynamics and formation by Hu, Chao, Shu, Li, Huang, Xiaoshuai, Yu, Jianglong, Li, liuju, Gong, Longlong, Yang, Meigui, Wu, Zhida, Gao, Zhi, Zhao, Yungang, Chen, Liangyi, Song, Zhiyin

“…Mitochondrial cristae are the main site for oxidative phosphorylation, which is critical for cellular energy production. Upon different physiological or…”
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Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling by Shi, Yingying, Wang, You, Jiang, Huangang, Sun, Xuehua, Xu, Hui, Wei, Xue, Wei, Yan, Xiao, Guohui, Song, Zhiyin, Zhou, Fuxiang

“…Mitochondrial retrograde signaling (mito-RTG) triggered by mitochondrial dysfunction plays a potential role in regulating tumor metabolic reprogramming and…”
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Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease by Dong, Jun, Chen, Li, Ye, Fei, Tang, Junhui, Liu, Bing, Lin, Jiacheng, Zhou, Pang-Hu, Lu, Bin, Wu, Min, Lu, Jia-Hong, He, Jing-Jing, Engelender, Simone, Meng, Qingtao, Song, Zhiyin, He, He

“…Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular…”
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Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms by Dong, Yu, Zhuang, Xu-Xu, Wang, Yi-Ting, Tan, Jieqiong, Feng, Du, Li, Min, Zhong, Qing, Song, Zhiyin, Shen, Han-Ming, Fang, Evandro F., Lu, Jia-Hong

“…Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various diseases, including neurodegenerative diseases, cardiovascular diseases,…”
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The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy by Zheng, Liangde, Shu, Wen-Jie, Li, Yu-Min, Mari, Muriel, Yan, Chaojun, Wang, Dehe, Yin, Zhao-Hong, Jiang, Wei, Zhou, Yu, Okamoto, Koji, Reggiori, Fulvio, Klionsky, Daniel J., Song, Zhiyin, Du, Hai-Ning

“…Mitophagy is a critical process that safeguards mitochondrial quality control in order to maintain proper cellular homeostasis. Although the…”
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Diet and Adaptive Evolution of Alanine-Glyoxylate Aminotransferase Mitochondrial Targeting in Birds by Wang, Bing-Jun, Xia, Jing-Ming, Wang, Qian, Yu, Jiang-Long, Song, Zhiyin, Zhao, Huabin

“…Adaptations to different diets represent a hallmark of animal diversity. The diets of birds are highly variable, making them an excellent model system for…”
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OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation by Ban, Tadato, Heymann, Jürgen A.W., Song, Zhiyin, Hinshaw, Jenny E., Chan, David C.

“…The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells. OPA1…”
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Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis by Song, Zhiyin, Yao, Xuebiao, Wu, Mian

“…Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and cell cycle control. However,…”
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The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver by Gong, Changxia, Li, Chengwei, Qi, Xiaoqing, Song, Zhiyin, Wu, Jianguo, Hughes, Michael E, Li, Xiaodong

“…The circadian clock regulates many cellular processes, notably including the cell cycle, metabolism and aging. Mitochondria play essential roles in metabolism…”
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LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function by Li, Yujie, Huang, Dawei, Jia, Lianqun, Shangguan, Fugen, Gong, Shiwei, Lan, Linhua, Song, Zhiyin, Xu, Juan, Yan, Chaojun, Chen, Tongke, Tan, Yin, Liu, Yongzhang, Huang, Xingxu, Suzuki, Carolyn K, Yang, Zhongzhou, Yang, Guanlin, Lu, Bin

“…Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and homeostasis. In particular, the…”
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Regulation of mitochondrial permeability transition pore by PINK1 by Gautier, Clement A, Giaime, Emilie, Caballero, Erica, Núñez, Lucía, Song, Zhiyin, Chan, David, Villalobos, Carlos, Shen, Jie

“…Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson's disease, but the underlying pathogenic mechanism remains…”
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