Search Results - "Song, Xiaojia"
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Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3
Published in The Journal of immunology (1950) (15-04-2020)“…Sepsis is a life-threatening condition with limited therapeutic options, characterized as excessive systemic inflammation and multiple organ failure…”
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Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway
Published in Molecular metabolism (Germany) (01-05-2019)“…Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms…”
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Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake
Published in Cell death and differentiation (01-05-2020)“…Non-alcoholic fatty liver disease (NAFLD) leads to hepatocellular carcinoma (HCC). However, the underlying mechanism remains largely unclear. Here, we…”
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UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming
Published in Journal of experimental & clinical cancer research (30-09-2024)“…Metabolic reprogramming plays a pivotal role in tumorigenesis and development of lung adenocarcinoma (LUAD). However, the precise mechanisms and potential…”
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ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury
Published in Nature communications (18-11-2023)“…Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators, such as PGC-1α and MCJ, affect liver regeneration. Therefore,…”
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Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners
Published in Antiviral research (01-05-2018)“…Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the stable genomic form as the template for viral transcription, plays a crucial role in viral…”
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ZHX2 restricts hepatocellular carcinoma by suppressing stem cell-like traits through KDM2A-mediated H3K36 demethylation
Published in EBioMedicine (01-03-2020)“…Liver cancer stem cells (CSCs) are critical determinants of HCC relapse and therapeutic resistance, but the mechanisms underlying the maintenance of CSCs are…”
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CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer
Published in Translational oncology (01-01-2022)“…•RFA induces limited abscopal effect in liver cancer.•Macrophages gain insufficient immunoregulatory function in abscopal effect.•RFA reduces CD169+…”
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LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1
Published in Advanced science (01-05-2022)“…Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form…”
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Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages
Published in Gut (01-10-2015)“…Tumour-associated macrophages (TAMs) and their alternative activation contribute greatly to the development of hepatocellular carcinoma (HCC). Tim-3 is highly…”
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Accelerating kNN search in high dimensional datasets on FPGA by reducing external memory access
Published in Future generation computer systems (01-12-2022)“…Implementing an efficient k-Nearest Neighbors (kNN) algorithm on FPGA is becoming challenging due to the fact that both the size and dimensionality of datasets…”
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DAPK1 mediates cognitive dysfunction and neuronal apoptosis in PSD rats through the ERK/CREB/BDNF signaling pathway
Published in Behavioural brain research (05-08-2024)“…Post-stroke depression (PSD) is one of the most common mental sequelae after a stroke and can damage the brain. Although PSD has garnered increasing attention…”
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Tim-3 Hampers Tumor Surveillance of Liver-Resident and Conventional NK Cells by Disrupting PI3K Signaling
Published in Cancer research (Chicago, Ill.) (01-03-2020)“…Natural killer (NK) cells are enriched within the liver. Apart from conventional NK (cNK) cells, recent studies identified a liver-resident NK (LrNK) subset,…”
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HBV suppresses ZHX2 expression to promote proliferation of HCC through miR‐155 activation
Published in International journal of cancer (15-12-2018)“…Initiation of hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection is a complex process that includes both oncogene activation and tumor…”
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A Memory-Access-Efficient Adaptive Implementation of kNN on FPGA through HLS
Published in 2019 IEEE 37th International Conference on Computer Design (ICCD) (01-11-2019)“…To reduce the impact of the memory-access constraint in k-Nearest Neighbors (kNN) problems, in this paper we implement one kNN kernel through high-level…”
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Conference Proceeding -
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ZHX2 inhibits SREBP1c‐mediated de novo lipogenesis in hepatocellular carcinoma via miR‐24‐3p
Published in The Journal of pathology (01-12-2020)“…Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related death worldwide. Lipogenesis has been considered as a critical player in HCC…”
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Enhancing bone regeneration by combining mesenchymal stem cell sheets with β-TCP/COL-I scaffolds
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-07-2018)“…The combination of bone marrow-derived mesenchymal stem cells (BMSCs) and biological scaffolds has been demonstrated to be a promising strategy for bone…”
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Correction: Zhx2 Accelerates Sepsis by Promoting Macrophage Glycolysis via Pfkfb3
Published in The Journal of immunology (1950) (15-06-2021)Get full text
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Tim‐3 blockade promotes iNKT cell function to inhibit HBV replication
Published in Journal of cellular and molecular medicine (01-06-2018)“…Increased expression of T cell immunoglobulin and mucin domain‐3 (Tim‐3) on invariant natural killer T (iNKT) cells is reported in chronic hepatitis B virus…”
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Journal Article