Search Results - "Song, Xiangrong"
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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Published in Signal transduction and targeted therapy (25-06-2022)“…Pseudomonas aeruginosa ( P. aeruginosa ) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency,…”
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A Novel Top‐Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging‐Guided Cancer Therapy
Published in Advanced materials (Weinheim) (06-09-2018)“…Single atom nonmetal 2D nanomaterials have shown considerable potential in cancer nanomedicines, owing to their intriguing properties and biocompatibility…”
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mRNA-based therapeutics: powerful and versatile tools to combat diseases
Published in Signal transduction and targeted therapy (21-05-2022)“…The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and…”
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mRNA Vaccines Against SARS‐CoV‐2 Variants Delivered by Lipid Nanoparticles Based on Novel Ionizable Lipids
Published in Advanced functional materials (26-09-2022)“…SARS‐CoV‐2 variants are now still challenging all the approved vaccines, including mRNA vaccines. There is an urgent need to develop new generation mRNA…”
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Optimal Design of Validation Experiment for Material Deterioration
Published in Materials (26-08-2023)“…For the deterioration model of a material, it is crucial to design a validation experiment to determine the ability of the deterioration model to simulate the…”
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A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
Published in Nature communications (17-09-2022)“…The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the higher…”
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Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy
Published in Kidney international (01-07-2018)“…Two distinct macrophage phenotypes contribute to kidney injury and repair during the progression of renal interstitial fibrosis; proinflammatory (M1) and…”
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Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants
Published in Nature communications (09-05-2023)“…Mucosal immunity plays a significant role in the first-line defense against viruses transmitted and infected through the respiratory system, such as…”
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Clinical translation of gene medicine
Published in The journal of gene medicine (01-07-2019)“…Gene therapy has recently witnessed accelerated progress as a new therapeutic strategy with the potential to treat a range of inherited and acquired diseases…”
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Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice
Published in Neuropharmacology (15-02-2022)“…Decreased energy metabolism and mitochondrial biogenesis defects are implicated in the pathogenesis of Alzheimer's disease (AD). In present study,…”
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Nanoliposome-Encapsulated Brinzolamide-hydropropyl-β-cyclodextrin Inclusion Complex: A Potential Therapeutic Ocular Drug-Delivery System
Published in Frontiers in pharmacology (13-02-2018)“…Novel ocular drug delivery systems (NODDSs) remain to be explored to overcome the anatomical and physiological barriers of the eyes. This study was to…”
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Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma
Published in Chinese chemical letters (01-02-2020)“…We prepared the core-shell lipid-polymer nanoparticles (LPNs) as the carriers of brinzolamide (Brz-LPNs) and investigated the potential of enhancing sustained…”
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LMP2-mRNA lipid nanoparticle sensitizes EBV-related tumors to anti-PD-1 therapy by reversing T cell exhaustion
Published in Journal of nanobiotechnology (08-09-2023)“…Abstract Background Targeting EBV-proteins with mRNA vaccines is a promising way to treat EBV-related tumors like nasopharyngeal carcinoma (NPC). We assume…”
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Identifying and assessing a prognostic model based on disulfidptosis-related genes: implications for immune microenvironment and tumor biology in lung adenocarcinoma
Published in Frontiers in immunology (22-05-2024)“…Lung cancer, with the highest global mortality rate among cancers, presents a grim prognosis, often diagnosed at an advanced stage in nearly 70% of cases…”
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PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: Systematic study of particle size and drug entrapment efficiency
Published in International journal of pharmaceutics (28-02-2008)“…PLGA nanoparticles simultaneously loaded with vincristine sulfate (VCR) and verapamil hydrochloride (VRP) were prepared via combining O/W emulsion solvent…”
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PCAS: An Integrated Tool for Multi-Dimensional Cancer Research Utilizing Clinical Proteomic Tumor Analysis Consortium Data
Published in International journal of molecular sciences (01-06-2024)“…Proteomics offers a robust method for quantifying proteins and elucidating their roles in cellular functions, surpassing the insights provided by…”
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Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs
Published in Journal of occupational health (01-01-2020)“…Objectives Occupational exposure to trichloroethylene (TCE) induces trichloroethylene hypersensitivity syndrome (TCEHS), which causes hypersensitivity…”
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Lipid Nanoparticle Delivery System for mRNA Encoding B7H3‐redirected Bispecific Antibody Displays Potent Antitumor Effects on Malignant Tumors
Published in Advanced science (01-01-2023)“…The therapeutic use of bispecific T‐cell engaging (BiTE) antibodies has shown great potential for treating malignancies. BiTE can simultaneously engage CD3ε on…”
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Enhanced Anti-Inflammatory Activity of Tilianin Based on the Novel Amorphous Nanocrystals
Published in Pharmaceuticals (Basel, Switzerland) (01-05-2024)“…Tilianin (Til), a flavonoid glycoside, is well-known for its therapeutic promise in treating inflammatory disorders. Its poor water solubility and permeability…”
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Dual agents loaded PLGA nanoparticles: Systematic study of particle size and drug entrapment efficiency
Published in European journal of pharmaceutics and biopharmaceutics (01-06-2008)“…PLGA nanoparticles simultaneously loaded with vincristine sulfate (VCR) and quercetin (QC) were prepared via O/W emulsion solvent evaporation. Six independent…”
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