Search Results - "Song, Qingxuan"

Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts by Krishna, Vinod, Yin, Xuefeng, Song, Qingxuan, Walsh, Alice, Pocalyko, David, Bachman, Kurtis, Anderson, Ian, Madakamutil, Loui, Nagpal, Sunil

“…Fibroblast-like synoviocytes (FLS), one of the main cell types of the rheumatoid arthritis (RA) synovium, possess phenotypic and molecular characteristics of…”
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Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment by Lowe, Katie, Small, Annabelle, Song, Qingxuan, Hao, Ling-Yang, Murray-Brown, William, Proudman, Susanna, Smith, Malcolm D., Nagpal, Sunil, Wechalekar, Mihir D.

“…Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known…”
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Pooled segregant sequencing reveals genetic determinants of yeast pseudohyphal growth by Song, Qingxuan, Johnson, Cole, Wilson, Thomas E, Kumar, Anuj

“…The pseudohyphal growth response is a dramatic morphological transition and presumed foraging mechanism wherein yeast cells form invasive and surface-spread…”
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Guselkumab induces robust reduction in acute phase proteins and type 17 effector cytokines in active psoriatic arthritis: results from phase 3 trials by Sweet, Kristen, Song, Qingxuan, Loza, Matthew J, McInnes, Iain B, Ma, Keying, Leander, Karen, Lakshminarayanan, Vani, Franks, Carol, Cooper, Philip, Siebert, Stefan

“…ObjectiveTo investigate serum protein expression in participants with psoriatic arthritis (PsA) and changes after guselkumab treatment.MethodsParticipants with…”
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Guselkumab Modulates Differentially Expressed Genes in Blood of Patients With Psoriatic Arthritis: Results from Two Phase 3, Randomized, Placebo-Controlled Trials by Siebert, Stefan, Sweet, Kristen M, Ritchlin, Christopher T, Hsia, Elizabeth C, Kollmeier, Alexa P, Xu, Xie L, Seridi, Loqmane, Song, Qingxuan, Gao, Sheng, Chen, Warner, Miron, Michelle

“…To evaluate gene expression in blood of patients with psoriatic arthritis (PsA) versus healthy controls and identify changes associated with guselkumab…”
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An Overview of Autophagy and Yeast Pseudohyphal Growth: Integration of Signaling Pathways during Nitrogen Stress by Song, Qingxuan, Kumar, Anuj

“…The budding yeast Saccharomyces cerevisiae responds to nutritional stress through the regulated activities of signaling pathways mediating autophagy and other…”
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Cost Effective Model for Genomic Screening for Familial Hypercholesterolemia Mutations in Populations With High LDL Cholesterol Levels by Fishberg, Robert, MD, FACC, Song, Qingxuan, PhD, Rosenberg, Zeil, MD, Zamarelli, Danielle, RN

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A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis by Bharucha, Nike, Chabrier-Rosello, Yeissa, Xu, Tao, Johnson, Cole, Sobczynski, Sarah, Song, Qingxuan, Dobry, Craig J, Eckwahl, Matthew J, Anderson, Christopher P, Benjamin, Andrew J, Kumar, Anju, Krysan, Damian J

“…The morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways…”
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LncRNA XIST regulates breast cancer stem cells by activating proinflammatory IL-6/STAT3 signaling by Ma, Yuxi, Zhu, Yongyou, Shang, Li, Qiu, Yan, Shen, Na, Wang, Jonathan, Adam, Tiffany, Wei, Wei, Song, Qingxuan, Li, Jun, Wicha, Max S., Luo, Ming

“…Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome inactivation (XCI) in early embryogenesis, is a common feature of breast…”
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Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations by Hanlon, Megan M, McGarry, Trudy, Marzaioli, Viviana, Amaechi, Success, Song, Qingxuan, Nagpal, Sunil, Veale, Douglas J, Fearon, Ursula

“…Abstract Objectives Myeloid cells with a monocyte/macrophage phenotype are present in large numbers in the RA joint, significantly contributing to disease;…”
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Abstract 2611: A crowdsourcing-based clinical trial information curation and searching system by Yu, Pengfei, Song, Qingxuan, Han, Yang, Hu, Guanghui

“…Abstract Targeted cancer therapies based on actionable mutations identified are the future of cancer treatment. Besides those approved by the Food and Drug…”
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Abstract 5357: OncoGxSelectTM - a beneficial supplement to comprehensive cancer genetic test by Han, Yang, Yu, Pengfei, Song, Qingxuan, Wei, Min, Hu, Guanghui

“…Abstract Genetic profiling of tumor has been widely accepted both in oncology research and clinical field. However, clinical doctors are sometimes overwhelmed…”
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P273 Ustekinumab and guselkumab treatment results in differences in serum IL-17A, IL-17F and CRP levels in PsA patients: a comparison from ustekinumab Phase 3 and guselkumab Phase 2 programmes by Siebert, Stefan, Loza, Matthew J, Song, Qingxuan, Gorecki, Patricia C, McInnes, Iain B, Sweet, Kristen

“…Abstract Background Ustekinumab (UST) is a monoclonal antibody (mAb) that binds the p40 epitope which is shared by IL-12 and IL-23, whereas guselkumab (GUS) is…”
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32938 Guselkumab treatment modulates genes differentially expressed in blood samples of patients with psoriatic arthritis vs healthy controls in two phase 3 clinical trials (DISCOVER-1 and -2) by Siebert, Stefan, Sweet, Kristen M., Ritchlin, Christopher T., Hsia, Elizabeth C., Kollmeier, Alexa P., Yang, Ya-Wen, Xu, Xie L., Song, Qingxuan, Miron, Michelle

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Genetic and Molecular Distinctions Between Axial Psoriatic Arthritis and Radiographic Axial Spondyloarthritis: Post Hoc Analyses from Four Phase 3 Clinical Trials by Kavanaugh, Arthur, Baraliakos, Xenofon, Gao, Sheng, Chen, Warner, Sweet, Kristen, Chakravarty, Soumya D., Song, Qingxuan, Shawi, May, Rahman, Proton

“…Introduction Emerging evidence suggests psoriatic arthritis (PsA) with axial involvement (axPsA) and radiographic axial spondyloarthritis (r-axSpA)…”
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Abstract 3633: OncoGxOneTM - an advanced genomic test for precision cancer treatment by Han, Yang, Yu, Pengfei, Song, Qingxuan, Wei, Min, Hu, Guanghui

“…Abstract The fundamental cause of cancer is the aberration of genes that control cell proliferation and apoptosis. With the rapid advancement of genomic…”
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Cancer classification in the genomic era: five contemporary problems by Song, Qingxuan, Merajver, Sofia D, Li, Jun Z

“…Classification is an everyday instinct as well as a full-fledged scientific discipline. Throughout the history of medicine, disease classification is central…”
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Abstract 3579: RegCAR-TTM: Enabling next-generation CAR-T therapy by Zhang, Xu, Tang, Ke, Song, Qingxuan, Chen, Si, Kasbek, christopher, Wang, Tianjiao, Huang, Jun

“…Abstract Chimeric Antigen Receptor (CAR) T-Cell Therapy has been emerging as a means of powerful cancer immunotherapy with its exceptional therapeutic…”
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The Phase 2 CARTITUDE-2 Trial: Updated Efficacy and Safety of Ciltacabtagene Autoleucel in Patients with Multiple Myeloma and 1-3 Prior Lines of Therapy (Cohort A) and with Early Relapse after First Line Treatment (Cohort B) by Hillengass, Jens, Cohen, Adam D., Agha, Mounzer E, Delforge, Michel, Kerre, Tessa, Roeloffzen, Wilfried, Einsele, Hermann, Goldschmidt, Hartmut, Weisel, Katja, Raab, Marc S., Scheid, Christof, Anguille, Sebastien, Sonneveld, Pieter, Zweegman, Sonja, Schecter, Jordan M., De Braganca, Kevin C, Jackson, Carolyn Chang, Vlummens, Philip, Varsos, Helen, Corsale, Christina, Madduri, Deepu, Yeh, Tzu-min, Mistry, Pankaj, Roccia, Tito, Song, Qingxuan, Akram, Muhammad, Costa Filho, Octavio, Geng, Dong, Cohen, Yael C., Van De Donk, Niels W.C.J.

“…Introduction: CARTITUDE-2 (NCT04133636) is a phase 2, multicohort study evaluating the safety and efficacy of ciltacabtagene autoleucel (cilta-cel), an…”
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MM-505 Efficacy and Safety of Ciltacabtagene Autoleucel ± Lenalidomide Maintenance in Newly Diagnosed Multiple Myeloma With Suboptimal Response to Frontline Autologous Stem Cell Transplant: CARTITUDE-2 Cohort D by Arnulf, Bertrand, Kerre, Tessa, Agha, Mounzer, Delforge, Michel, Braunschweig, Ira, Shah, Nishi, Richard, Shambavi, Alsina, Melissa, Einsele, Hermann, Mistry, Pankaj, Varsos, Helen, Corsale, Christina, Schecter, Jordan, De Braganca, Kevin, Jethava, Yogesh, Song, Qingxuan, Koneru, Mythili, Akram, Muhammad, Cohen, Yaël, Roeloffzen, Wilfried

“…CARTITUDE-2 is a phase 2 multicohort study evaluating ciltacabtagene autoleucel (cilta-cel), including cilta-cel ± lenalidomide maintenance in patients with…”
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