Search Results - "Song, Nanshan"

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection by Wei, Yao, Lu, Ming, Mei, Meng, Wang, Haoran, Han, Zhitao, Chen, Miaomiao, Yao, Hang, Song, Nanshan, Ding, Xiao, Ding, Jianhua, Xiao, Ming, Hu, Gang

“…Oxidative stress is a major pathogenic mechanism in Parkinson’s disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production…”
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Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease by Han, Xiaojuan, Sun, Sifan, Sun, Yiming, Song, Qiqi, Zhu, Jialei, Song, Nanshan, Chen, Miaomiao, Sun, Ting, Xia, Meiling, Ding, Jianhua, Lu, Ming, Yao, Honghong, Hu, Gang

“…Aging-related, nonresolving inflammation in both the central nervous system (CNS) and periphery predisposes individuals to the development of neurodegenerative…”
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Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3 by Fang, Yinquan, Jiang, Qingling, Li, Shanshan, Zhu, Hong, Xu, Rong, Song, Nanshan, Ding, Xiao, Liu, Jiaqi, Chen, Miaomiao, Song, Mengmeng, Ding, Jianhua, Lu, Ming, Wu, Guangyu, Hu, Gang

“…Although β-arrestins (ARRBs) regulate diverse physiological and pathophysiological processes, their functions and regulation in Parkinson’s disease (PD) remain…”
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NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression by Li, Shanshan, Sun, Yiming, Song, Mengmeng, Song, Yuting, Fang, Yinquan, Zhang, Qingyu, Li, Xueting, Song, Nanshan, Ding, Jianhua, Lu, Ming, Hu, Gang

“…Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder…”
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β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression by Liu, Yang, Song, Nanshan, Yao, Hang, Jiang, Siyuan, Wang, Yueping, Zheng, Ying, Zhou, Yuanzhang, Ding, Jianhua, Hu, Gang, Lu, Ming

“…Abstract Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice,…”
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Focusing on mitochondria in the brain: from biology to therapeutics by Song, Nanshan, Mei, Shuyuan, Wang, Xiangxu, Hu, Gang, Lu, Ming

“…Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are…”
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Corrigendum: Induced expression of kir6.2 in A1 astrocytes propagates inflammatory neurodegeneration via Drp1-dependent mitochondrial fission by Song, Nanshan, Zhu, Hong, Xu, Rong, Liu, Jiaqi, Fang, Yinquan, Zhang, Jing, Ding, Jianhua, Hu, Gang, Lu, Ming

“…[This corrects the article DOI: 10.3389/fphar.2020.618992.]…”
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Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission by Song, Nanshan, Zhu, Hong, Xu, Rong, Liu, Jiaqi, Fang, Yinquan, Zhang, Jing, Ding, Jianhua, Hu, Gang, Lu, Ming

“…Glia-mediated inflammatory processes are crucial in the pathogenesis of Parkinson's disease (PD). As the most abundant cells of the brain and active…”
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Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation by Song, Nanshan, Fang, Yinquan, Zhu, Hong, Liu, Jiaqi, Jiang, Siyuan, Sun, Sifan, Xu, Rong, Ding, Jianhua, Hu, Gang, Lu, Ming

“…Kir6.2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels, regulates the functions of metabolically active tissues and acts as an ideal…”
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Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease by Liu, Yang, Liu, Ting, Zhou, Yuanzhang, Li, Wenjie, Wang, Min, Song, Nanshan, Zhang, Wenbin, Jiang, Jingwei, Yuan, Shengtao, Ding, Jianhua, Hu, Gang, Lu, Ming

“…Alanine–serine–cysteine transporter 2 (ASCT2) is reported to participate in the progression of tumors and metabolic diseases. It is also considered to play a…”
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CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy by Zhou, Yuanzhang, Liu, Yang, Kang, Zhengwei, Yao, Hang, Song, Nanshan, Wang, Min, Song, Chenghuan, Zhang, Kezhong, Ding, Jianhua, Tang, Juanjuan, Hu, Gang, Lu, Ming

“…Despite growing evidence that has declared the importance of circRNAs in neurodegenerative diseases, the clinical significance of circRNAs in dopaminergic (DA)…”
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Salmeterol, agonist of β2-aderenergic receptor, prevents systemic inflammation via inhibiting NLRP3 inflammasome by Song, Nanshan, Fang, Yinquan, Sun, Xiyang, Jiang, Qingling, Song, Chenghuan, Chen, Miaomiao, Ding, Jianhua, Lu, Ming, Hu, Gang

“…[Display omitted] β2-Aderenergic receptor (β2AR) agonist, Salmeterol exhibits anti-inflammatory activities. However, the inhibitory effects of Salmeterol on…”
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Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between [beta]-arrestin2 and STAT3 in mouse model of depression by Liu, Yang, Song, Nanshan, Yao, Hang, Jiang, Siyuan, Wang, Yueping, Zheng, Ying, Zhou, Yuanzhang, Ding, Jianhua, Hu, Gang, Lu, Ming

“…Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally…”
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An imbalance of netrin‐1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease by Hua, Ye, Han, Wenjing, Zhou, Linfeng, Gao, Jing, Zhao, Jifeng, Song, Nanshan, Hu, Bin, Yao, Qingyu, Liu, Yumin, Xu, Deen, Lu, Yunnan, Fan, Yi

“…Aims Multiple guidance cues, such as netrin‐1 (NTN‐1)/deleted in colorectal carcinoma (DCC), control the guidance of axons and help establish functional neural…”
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Antagonism of β-arrestins in IL-4-driven microglia reactivity via the Samd4/mTOR/OXPHOS axis in Parkinson's disease by Liu, Jiaqi, Liang, Yue, Meng, Qinghao, Chen, Jiayu, Ma, Junwei, Zhu, Hong, Cai, Lei, Song, Nanshan, Ding, Jianhua, Fan, Yi, Lu, Ming, Wu, Guangyu, Fang, Yinquan, Hu, Gang

“…Interleukin-4 (IL-4)-exposed microglia acquire neuroprotective properties, but their functions and regulation in Parkinson's disease (PD) are poorly…”
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