Search Results - "Song, Jian H"

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis by Ling, Hui, Pickard, Karen, Ivan, Cristina, Isella, Claudio, Ikuo, Mariko, Mitter, Richard, Spizzo, Riccardo, Bullock, Marc, Braicu, Cornelia, Pileczki, Valentina, Vincent, Kimberly, Pichler, Martin, Stiegelbauer, Verena, Hoefler, Gerald, Almeida, Maria I, Hsiao, Annie, Zhang, Xinna, Primrose, John, Packham, Graham, Liu, Kevin, Bojja, Krishna, Gafà, Roberta, Xiao, Lianchun, Rossi, Simona, Song, Jian H, Vannini, Ivan, Fanini, Francesca, Kopetz, Scott, Zweidler-McKay, Patrick, Wang, Xuemei, Ionescu, Calin, Irimie, Alexandru, Fabbri, Muller, Lanza, Giovanni, Hamilton, Stanley R, Berindan-Neagoe, Ioana, Medico, Enzo, Mirnezami, Alex, Calin, George A, Nicoloso, Milena S

“…MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC)…”
Get more information

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy by Gaur, Sanchaika, Wen, Yunfei, Song, Jian H, Parikh, Nila U, Mangala, Lingegowda S, Blessing, Alicia M, Ivan, Cristina, Wu, Sherry Y, Varkaris, Andreas, Shi, Yan, Lopez-Berestein, Gabriel, Frigo, Daniel E, Sood, Anil K, Gallick, Gary E

“…While several new therapies are FDA-approved for bone-metastatic prostate cancer (PCa), patient survival has only improved marginally. Here, we report that…”
Get full text

Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling by Karanika, Styliani, Karantanos, Theodoros, Li, Likun, Wang, Jianxiang, Park, Sanghee, Yang, Guang, Zuo, Xuemei, Song, Jian H., Maity, Sankar N., Manyam, Ganiraju C., Broom, Bradley, Aparicio, Ana M., Gallick, Gary E., Troncoso, Patricia, Corn, Paul G., Navone, Nora, Zhang, Wei, Li, Shuhua, Thompson, Timothy C.

“…Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is…”
Get full text

A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus by Bohren, Kurt M., Nadkarni, Varsha, Song, Jian H., Gabbay, Kenneth H., Owerbach, David

“…Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance…”
Get full text

Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis by Lee, Yu-Chen, Jin, Jung-Kang, Cheng, Chien-Jui, Huang, Chih-Fen, Song, Jian H, Huang, Miao, Brown, Wells S, Zhang, Sui, Yu-Lee, Li-Yuan, Yeh, Edward T, McIntyre, Bradley W, Logothetis, Christopher J, Gallick, Gary E, Lin, Sue-Hwa

“…Disseminated prostate cancer cells must survive in circulation for metastasis to occur. Mechanisms by which these cells survive are not well understood. By…”
Get full text

BIGH3 Promotes Osteolytic Lesions in Renal Cell Carcinoma Bone Metastasis by Inhibiting Osteoblast Differentiation by Pan, Tianhong, Lin, Song-Chang, Yu, Kai-Jie, Yu, Guoyu, Song, Jian H., Lewis, Valerae O., Bird, Justin E., Moon, Bryan, Lin, Patrick P., Tannir, Nizar M., Jonasch, Eric, Wood, Christopher G, Gallick, Gary E., Yu-Lee, Li-Yuan, Lin, Sue-Hwa, Satcher, Robert L.

“…BACKGROUND: Bone metastasis is common in renal cell carcinoma (RCC), and the lesions are mainly osteolytic. The mechanism of bone destruction in RCC bone…”
Get full text

Targeting Src and Tubulin in Mucinous Ovarian Carcinoma by TAO LIU, WEI HU, CHUNHUA LU, PECOT, Chad V, BOTTSFORD-MILLER, Justin, ZAND, Behrouz, JENNINGS, Nicholas B, IVAN, Cristina, GALLICK, Gary E, BAGGERLY, Keith A, HANGAUER, David G, COLEMAN, Robert L, DALTON, Heather J, FRUMOVITZ, Michael, SOOD, Anil K, HYUN JIN CHOI, JIE HUANG, YU KANG, PRADEEP, Sunila, MIYAKE, Takahito, SONG, Jian H, YUNFEI WEN

“…To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma. The in vitro and in vivo effects and molecular mechanisms of…”
Get full text

Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis by Lee, Yu-Chen, Bilen, Mehmet Asim, Yu, Guoyu, Lin, Song-Chang, Huang, Chih-Fen, Ortiz, Angelica, Cho, Hyojin, Song, Jian H, Satcher, Robert L, Kuang, Jian, Gallick, Gary E, Yu-Lee, Li-Yuan, Huang, Wilber, Lin, Sue-Hwa

“…Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a…”
Get full text

Endothelial-to-osteoblast transition in normal mouse bone development by Lin, Song-Chang, Yu, Guoyu, Lee, Yu-Chen, Song, Jian H., Song, Xingzhi, Zhang, Jianhua, Panaretakis, Theocharis, Logothetis, Christopher J., Komatsu, Yoshihiro, Yu-Lee, Li-Yuan, Wang, Guocan, Lin, Sue-Hwa

“…Metastatic prostate cancer (PCa) in bone induces bone-forming lesions. We have previously shown that PCa-induced bone originates from endothelial cells (ECs)…”
Get full text

Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways by Dayyani, Farshid, Parikh, Nila U, Varkaris, Andreas S, Song, Jian H, Moorthy, Shhyam, Chatterji, Tanushree, Maity, Sankar N, Wolfe, Adam R, Carboni, Joan M, Gottardis, Marco M, Logothetis, Christopher J, Gallick, Gary E

“…Treatment of metastatic prostate cancer (PCa) with single agents has shown only modest efficacy. We hypothesized dual inhibition of different pathways in PCa…”
Get full text

Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4 by Yu, Guoyu, Shen, Pengfei, Lee, Yu-Chen, Pan, Jing, Song, Jian H., Pan, Tianhong, Lin, Song-Chang, Liang, Xin, Wang, Guocan, Panaretakis, Theocharis, Logothetis, Christopher J., Gallick, Gary E., Yu-Lee, Li-Yuan, Lin, Sue-Hwa

“…Cell type transition occurs during normal development and under pathological conditions. In prostate cancer bone metastasis, prostate cancer-secreted BMP4…”
Get full text

Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer by Li, Likun, Karanika, Styliani, Yang, Guang, Wang, Jiangxiang, Park, Sanghee, Broom, Bradley M, Manyam, Ganiraju C, Wu, Wenhui, Luo, Yong, Basourakos, Spyridon, Song, Jian H, Gallick, Gary E, Karantanos, Theodoros, Korentzelos, Dimitrios, Azad, Abul Kalam, Kim, Jeri, Corn, Paul G, Aparicio, Ana M, Logothetis, Christopher J, Troncoso, Patricia, Heffernan, Timothy, Toniatti, Carlo, Lee, Hyun-Sung, Lee, Ju-Seog, Zuo, Xuemei, Chang, Wenjun, Yin, Jianhua, Thompson, Timothy C

“…Cancers with loss-of-function mutations in or are deficient in the DNA damage repair pathway called homologous recombination (HR), rendering these cancers…”
Get more information

Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer by Zhao, Di, Cai, Li, Lu, Xin, Liang, Xin, Li, Jiexi, Chen, Peiwen, Ittmann, Michael, Shang, Xiaoying, Jiang, Shan, Li, Haoyan, Meng, Chenling, Flores, Ivonne, Song, Jian H, Horner, James W, Lan, Zhengdao, Wu, Chang-Jiun, Li, Jun, Chang, Qing, Chen, Ko-Chien, Wang, Guocan, Deng, Pingna, Spring, Denise J, Wang, Y Alan, DePinho, Ronald A

“…Genetic inactivation of is common in prostate cancer and correlates with poorer prognosis. We previously identified as an essential gene in PTEN-deficient…”
Get more information

Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization by Yu, Guoyu, Corn, Paul G, Mak, Celia Sze Ling, Liang, Xin, Zhang, Miao, Troncoso, Patricia, Song, Jian H, Lin, Song-Chang, Song, Xingzhi, Liu, Jingjing, Zhang, Jianhua, Logothetis, Christopher J, Melancon, Marites P, Panaretakis, Theocharis, Wang, Guocan, Lin, Sue-Hwa

“…Immune checkpoint therapy has limited efficacy for patients with bone-metastatic castration-resistant prostate cancer (bmCRPC). To improve immunotherapy for…”
Get full text

Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions by Blocking the Endothelial-to-Osteoblast Transition by Yu, Guoyu, Corn, Paul G, Shen, Pengfei, Song, Jian H, Lee, Yu-Chen, Lin, Song-Chang, Pan, Jing, Agarwal, Sandeep K, Panaretakis, Theocharis, Pacifici, Maurizio, Logothetis, Christopher J, Yu-Lee, Li-Yuan, Lin, Sue-Hwa

“…Metastatic prostate cancer in the bone induces bone-forming lesions that contribute to progression and therapy resistance. Prostate cancer-induced bone…”
Get full text

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition by Lee, Yu-Chen, Lin, Song-Chang, Yu, Guoyu, Zhu, Ming, Song, Jian H., Rivera, Keith, Pappin, Darryl J., Logothetis, Christopher J., Panaretakis, Theocharis, Wang, Guocan, Yu-Lee, Li-Yuan, Lin, Sue-Hwa

“…Metastatic prostate cancer (PCa) in bone induces bone-forming lesions that enhance PCa progression. How tumor-induced bone formation enhances PCa progression…”
Get full text

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis by Zhu, Ming, Peng, Ruiqing, Liang, Xin, Lan, Zhengdao, Tang, Ming, Hou, Pingping, Song, Jian H., Mak, Celia Sze Ling, Park, Jiwon, Zheng, Shui-er, Huang, Ailing, Ma, Xingdi, Chen, Ruidong, Chang, Qing, Logothetis, Christopher J., Jain, Abhinav K., Lin, Sue-Hwa, Katayama, Hiroyuki, Hanash, Samir, Wang, Guocan

“…Yes-associated protein 1 (YAP1), a key player in the Hippo pathway, has been shown to play a critical role in tumor progression. However, the role of YAP1 in…”
Get full text

Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone by Pan, Tianhong, Lin, Song-Chang, Lee, Yu-Chen, Yu, Guoyu, Song, Jian H., Pan, Jing, Titus, Mark, Satcher, Robert L., Panaretakis, Theocharis, Logothetis, Christopher, Yu-Lee, Li-Yuan, Lin, Sue-Hwa

“…A fraction of patients undergoing androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) will develop recurrent castrate-resistant PCa (CRPC) in…”
Get full text

Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment by Vardaki, Ioulia, Corn, Paul, Gentile, Emanuela, Song, Jian H, Madan, Namrata, Hoang, Anh, Parikh, Nila, Guerra, Leah, Lee, Yu-Chen, Lin, Song-Chang, Yu, Guoyu, Santos, Elmer, Melancon, Marites P, Troncoso, Patricia, Navone, Nora, Gallick, Gary E, Efstathiou, Eleni, Subudhi, Sumit K, Lin, Sue-Hwa, Logothetis, Christopher J, Panaretakis, Theocharis

“…Radium-223 prolongs survival in a fraction of men with bone metastatic prostate cancer (PCa). However, there are no markers for monitoring response and…”
Get full text

BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression by Pan, Tianhong, Liu, Fengshuo, Hao, Xiaoxin, Wang, Shubo, Wasi, Murtaza, Song, Jian H., Lewis, Valerae O., Lin, Patrick P., Moon, Bryan, Bird, Justin E., Panaretakis, Theocharis, Lin, Sue-Hwa, Wu, Danielle, Farach-Carson, Mary C., Wang, Liyun, Zhang, Ningyan, An, Zhiqiang, Zhang, Xiang H.-F., Satcher, Robert L.

“…Renal cell carcinoma (RCC) bone metastatis progression is driven by crosstalk between tumor cells and the bone microenvironment, which includes osteoblasts,…”
Get full text