Search Results - "Song, Jiagui"

Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice by Chi, Xiaochun, Luo, Weiwei, Song, Jiagui, Li, Bing, Su, Tiantian, Yu, Miao, Wang, Tianzhuo, Wang, Zhenbin, Liu, Cheng, Li, Zhen, He, Huiying, Zhan, Jun, Zhang, Hongquan

“…Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels…”
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The role of cholesterol metabolism in tumor therapy, from bench to bed by Xia, Wenhao, Wang, Hao, Zhou, Xiaozhu, Wang, Yan, Xue, Lixiang, Cao, Baoshan, Song, Jiagui

“…Cholesterol and its metabolites have important biological functions. Cholesterol is able to maintain the physical properties of cell membrane, play an…”
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Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1 by Song, Jiagui, Wang, Tianzhuo, Chi, Xiaochun, Wei, Xiaofan, Xu, Sidi, Yu, Miao, He, Huiying, Ma, Ji, Li, Xueying, Du, Juan, Sun, Xiaoran, Wang, Yunling, Zhan, Jun, Zhang, Hongquan

“…The Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this pathway are less well…”
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EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment by Li, Chen, Song, Jiagui, Guo, Zhengyang, Gong, Yueqing, Zhang, Tengrui, Huang, Jiaqi, Cheng, Rui, Yu, Xiaotong, Li, Yanfang, Chen, Li, Ma, Xiaojuan, Sun, Yan, Wang, Yan, Xue, Lixiang

“…EZH2 inhibitors (EZH2i), a class of small-molecule inhibitors that target EZH2 to exert anti-tumor functions, have just been approved by the US Food and Drug…”
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Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland by Wang, Zhenbin, Zhang, Lei, Li, Bing, Song, Jiagui, Yu, Miao, Zhang, Jing, Chen, Ceshi, Zhan, Jun, Zhang, Hongquan

“…Myoepithelium plays an important role in mammary gland development, but less is known about the molecular mechanism underlying how myoepithelium controls…”
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FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth by Yu, Miao, Wu, Weijie, Sun, Yi, Yan, Haoyi, Zhang, Lei, Wang, Zhenbin, Gong, Yuqing, Wang, Tianzhuo, Li, Qianchen, Song, Jiagui, Wang, Mengyuan, Zhang, Jing, Tang, Yan, Zhan, Jun, Zhang, Hongquan

“…Cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (RB) are both important cell-cycle regulators that function in different scenarios. Here, we report…”
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Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal adenocarcinoma by Sun, Xiaoran, Song, Jiagui, Zhang, Jing, Zhan, Jun, Fang, Weigang, Zhang, Hongquan

“…Pancreatic ductal adenocarcinoma (PDAC) is the ninth most common human malignancy and the sixth leading cause of cancer-related death in China. AcK27-HOXB9 is…”
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Identification of Elm Yellows Phytoplasma in Plum Trees in China by Hong, Min, Zhang, Chunping, Li, Zhengnan, Zhang, Jue, Zhao, Zhen, Song, Jiagui, Wu, Yunfeng

“…Plum plants (Prunus cerasifera Ehrh) with small and rolled leaves resembling symptoms of phytoplasma infection were observed during 2008 and 2009 in the…”
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Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway by Shan, Baixi, Ai, Zhifu, Zeng, Sufen, Song, Yonggui, Song, Jiagui, Zeng, Qiang, Liao, Zhou, Wang, Tingting, Huang, Chao, Su, Dan

“…•Chronic stress perturb the composition of the gut microbiota and induce host anxiety-like behavior.•High concentration of lactate can cause memory and…”
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Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway by Jin, Jiaqi, Zhang, Lei, Li, Xueying, Xu, Weizhi, Yang, Siyuan, Song, Jiagui, Zhang, Wenhao, Zhan, Jun, Luo, Jianyuan, Zhang, Hongquan

“…Abstract Reactive oxygen species (ROS) are constantly produced in cells, an excess of which causes oxidative stress. ROS has been linked to regulation of the…”
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Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression by Jiang, Hao, Li, Tingting, Qu, Yi, Wang, Xiang, Li, Bing, Song, Jiagui, Sun, Xiaoran, Tang, Yan, Wan, Junhu, Yu, Yu, Zhan, Jun, Zhang, Hongquan

“…Slug is a fast-turnover transcription factor critical for controlling cell fate and cancer cell invasion and metastasis. The stability of Slug is important and…”
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Pulsatilla chinensis saponins cause liver injury through interfering ceramide/sphingomyelin balance that promotes lipid metabolism dysregulation and apoptosis by Su, Dan, Liao, Zhou, Feng, Binwei, Wang, Tingting, shan, Baixi, Zeng, Qiang, Song, Jiagui, Song, Yonggui

“…Background:P. chinensis saponins (PRS) are pentacyclic triterpenoid bioactive constituents from Pulsatilla chinensis (Bunge) Regel. In our previous study, PRS…”
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HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression by Song, Jiagui, Wang, Tianzhuo, Xu, Weizhi, Wang, Peng, Wan, Junhu, Wang, Yunling, Zhan, Jun, Zhang, Hongquan

“…We previously reported that HOXB9 is overexpressed in colon cancer and predicts a favourable patient outcome, which is opposite to the tumour-promoting role of…”
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Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9 by Zhan, Jun, Song, Jiagui, Wang, Peng, Chi, Xiaochun, Wang, Yunling, Guo, Yongqing, Fang, Weigang, Zhang, Hongquan

“…Highlights • Kindlin-2 is upregulated but HOXB9 is downregulated by TGF-β1 in PDAC cells. • Kindlin-2 upregulates but HOXB9 downregulates TβRI in PDAC cells. •…”
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The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations by Wang, Tianzhuo, Guo, Huiying, Li, Qianchen, Wu, Weijie, Yu, Miao, Zhang, Lei, Li, Cuicui, Song, Jiagui, Wang, Zhenbin, Zhang, Jing, Tang, Yan, Kang, Lei, Zhang, Hongquan, Zhan, Jun

“…HOXB9 is an important transcription factor associated with unfavorable outcomes in patients with lung adenocarcinoma (LUAD). However, its degradation mechanism…”
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HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients by Zhan, Jun, Wang, Peng, Li, Shuai, Song, Jiagui, He, Huiying, Wang, Yunling, Liu, Zhaofei, Wang, Fan, Bai, Hua, Fang, Weigang, Du, Quan, Ye, Min, Chang, Zhijie, Wang, Jie, Zhang, Hongquan

“…Distant metastasis and chemoresistance are the major causes of short survival after initial chemotherapy in lung adenocarcinoma patients. However, the…”
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Kindlin-2 deficiency induces fatal intestinal obstruction in mice by He, Xiaokun, Song, Jiagui, Cai, Zeyu, Chi, Xiaochun, Wang, Zhenbin, Yang, Decao, Xie, Sian, Zhou, Jing, Fu, Yi, Li, Wei, Kong, Wei, Zhan, Jun, Zhang, Hongquan

“…: Smooth muscle-motility disorders are mainly characterized by impaired contractility and functional intestinal obstruction. Some of these cases are caused by…”
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Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology by Wang, Peng, Zhan, Jun, Song, Jiagui, Wang, Yunling, Fang, Weigang, Liu, Zhihua, Zhang, Hongquan

“…Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins…”
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C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision by Ma, Ji, Liu, Cheng, Yang, Decao, Song, Jiagui, Zhang, Jing, Wang, Tianzhuo, Wang, Mengyuan, Xu, Weizhi, Li, Xueying, Ding, Shigang, Zhan, Jun, Zhang, Hongquan

“…Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with…”
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Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice by Li, Bing, Chi, Xiaochun, Song, Jiagui, Tang, Yan, Du, Juan, He, Xiaokun, Sun, Xiaoran, Bi, Zhenwu, Wang, Yunling, Zhan, Jun, Zhang, Hongquan

“…Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the…”
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