Search Results - "Song, Jeff"

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Molina, Jennifer R., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Varsamis, Zacharenia A., Nayak, Sunaina P., Bamberg, Ellen, Mo, Jan-Rung, Church, W. David, Mady, Ahmed S.A., Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative…”
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Rhesus macaques as a tractable physiological model of human ageing by Chiou, Kenneth L., Montague, Michael J., Goldman, Elisabeth A., Watowich, Marina M., Sams, Sierra N., Song, Jeff, Horvath, Julie E., Sterner, Kirstin N., Ruiz-Lambides, Angelina V., Martínez, Melween I., Higham, James P., Brent, Lauren J. N., Platt, Michael L., Snyder-Mackler, Noah

“…Research in the basic biology of ageing is increasingly identifying mechanisms and modifiers of ageing in short-lived organisms such as worms and mice. The…”
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New class of P-stereogenic chiral Brønsted acid catalysts derived from chiral phosphinamides by Han, Zhengxu S., Wu, Hao, Qu, Bo, Wang, Yuwen, Wu, Ling, Zhang, Li, Xu, Yibo, Wu, Linglin, Zhang, Yongda, Lee, Heewon, Roschangar, Frank, Song, Jeff J., Senanayake, Chris H.

“…[Display omitted] •New class of P-stereogenic chiral NH Brønsted acid organocatalysts prepared.•Catalysts were prepared from chiral phosphinamides or secondary…”
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Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Molina, Jennifer R., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Bamberg, Ellen, Mo, Jan-Rung, Church, David, Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in…”
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Synthesis of stable isotope‐labelled firocoxib by Latli, Bachir, Gao, Amy, Kvaternick, Valerie, Tecle, Berhane, Pennino, Scott, Yee, Nathan K., Song, Jeff

“…Firocoxib (ML‐1,785,713) is a nonsteroidal, potent, and selective COX‐2 inhibitor, approved for the control of pain and inflammation associated with…”
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Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression by Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Varsamis, Zacharenia A., Nayak, Sunaina P., Bamberg, Ellen, Mo, Jan-Rung, Church, William, Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in…”
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Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways by Vasbinder, Melissa M., Gozgit, Joseph M., Abo, Ryan P., Kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Lu, Alvin Z., Swinger, Kerren K., Wigle, Tim J., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Niepel, Mario, Varsamis, Zacharenia A., Nayak, Sunaina P., Bamberg, Ellen, Mo, Jan-Rung, Church, W David, Song, Jeff, Utley, Luke, Rao, Patricia E., Mitchison, Timothy J., Kuntz, Kevin W., Richon, Victoria M., Keilhack, Heike

“…Abstract RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways PARP7 is a monoPARP that…”
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Abstract 3260: Potentiation of Type I interferon signaling leads to in vivo efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397 by Kunii, Kaiko, Song, Jeff J., Zimmerman, Danielle, Liu, Chang, Kuplast-Barr, Kristy G., Novak, Jonathan J., Nayak, Sunaina P., Gozgit, Joseph M., Vasbinder, Melissa M., McEachern, Kristen, Kuntz, Kevin W., Keilhack, Heike, Molina, Jennifer R.

“…Abstract There are many pathways that activate the Type I interferon (IFN) response to combat tumor progression including the cytosolic nucleic acid sensing…”
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Assessment of multi-modality evaluations of obscure gastrointestinal bleeding by Law, Ryan, Varayil, Jithinraj E, WongKeeSong, Louis M, Fidler, Jeff, Fletcher, Joel G, Barlow, John, Alexander, Jeffrey, Rajan, Elizabeth, Hansel, Stephanie, Becker, Brenda, Larson, Joseph J, Enders, Felicity T, Bruining, David H, Coelho-Prabhu, Nayantara

“…AIM To determine the frequency of bleeding source detection in patients with obscure gastrointestinal bleeding（OGIB） who underwent double balloon…”
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Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models by Molina, Jennifer R., Gozgit, Joseph M., Vasbinder, Melissa M., Abo, Ryan P., kunii, Kaiko, Kuplast-Barr, Kristy G., Gui, Bin, Nayak, Sunaina P., Minissale, Elena, Swinger, Kerren K., Wigle, Tim J., Lu, Alvin Z., Blackwell, Danielle J., Majer, Christina R., Ren, Yue, Bamberg, Ellen, Niepel, Mario, Mo, Jan-Rung, Church, William D., Mady, Ahmed S., Song, Jeff, Varsamis, Zacharenia A., Utley, Luke, Rao, Patricia E., Mitchison, Timoty J., Kuntz, Kevin W., Richon, Victoria M., McEachern, Kristen, Keilhack, Heike

“…Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored…”
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Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats by Mezo, Adam R, McDonnell, Kevin A, Low, Susan C, Song, Jeff, Reidy, Tom J, Lu, Qi, Amari, John V, Hoehn, Todd, Peters, Robert T, Dumont, Jennifer, Bitonti, Alan J

“…Atrial natriuretic peptide (ANP) may be a useful molecule for the treatment of cardiovascular diseases due to its potent natriuretic effects. In an effort to…”
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ERCache: An Efficient and Reliable Caching Framework for Large-Scale User Representations in Meta's Ads System by Zhou, Fang, Huang, Yaning, Liang, Dong, Li, Dai, Zhang, Zhongke, Wang, Kai, Xin, Xiao, Aboelela, Abdallah, Jiang, Zheliang, Wang, Yang, Song, Jeff, Zhang, Wei, Liang, Chen, Li, Huayu, Sun, ChongLin, Yang, Hang, Qu, Lei, Shu, Zhan, Yuan, Mindi, Maccherani, Emanuele, Hayat, Taha, Guo, John, Puvvada, Varna, Pashkevich, Uladzimir

“…The increasing complexity of deep learning models used for calculating user representations presents significant challenges, particularly with limited…”
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Purification and characterization of a tachykinin-like peptide from skin secretions of the tree frog, Theloderma kwangsiensis by Zhang, Hao, Wei, Lin, Zou, Chengda, Bai, Jeff Jinfeng, Song, Yuzhu, Liu, Huan

“…Most amphibians belonging to Rhacophoridae have an arboreal life. A large amount of bioactive peptides have been identified from amphibian skin, but none from…”
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