Search Results - "Song, Emma"

Glycogen synthase kinase−3β inhibitors suppress leukemia cell growth by Song, Emma Y, Palladinetti, Patricia, Klamer, Guy, Ko, Kap-Hyoun, Lindeman, Robert, O'Brien, Tracey A, Dolnikov, Alla

“…Objective The objective of this study was to investigate the effect of small molecule inhibitors of glycogen synthase kinase−3β (GSK-3β) on leukemia cell…”
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Progress Toward the Determination of Correct Classification Rates in Fire Debris Analysis by Waddell, Erin E., Song, Emma T., Rinke, Caitlin N., Williams, Mary R., Sigman, Michael E.

“…Principal components analysis (PCA), linear discriminant analysis (LDA), and quadratic discriminant analysis (QDA) were used to develop a multistep…”
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Tumour anti-vascular alpha therapy: a mechanism for the regression of solid tumours in metastatic cancer by Allen, Barry J, Raja, Chand, Rizvi, Syed, Song, Emma Y, Graham, Peter

“…Targeted alpha therapy (TAT) is an emerging therapeutic modality, thought to be best suited to cancer micrometastases, leukaemia and lymphoma. TAT has not been…”
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Interim analysis of toxicity and response in phase 1 trial of systemic targeted alpha therapy for metastatic melanoma by Raja, Chand, Graham, Peter, Rizvi, Syed, Song, Emma, Goldsmith, Helen, Thompson, John, Bosserhoff, Anja, Morgenstern, Alfred, Apostolidis, Christos, Kearsley, John, Reisfeld, Ralph, Allen, Barry J

“…Purpose. The aim is to assess toxicity and response of systemic alpha therapy for metastatic melanoma. Experimental design. This is an open-labelled Phase 1…”
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GSK3 inhibition prevents lethal GVHD in mice by Klamer, Guy, Shen, Sylvie, Song, Emma, Rice, Alison M, Knight, Robert, Lindeman, Robert, O’Brien, Tracey A, Dolnikov, Alla

“…Graft-versus-host disease (GVHD) is a major contributor to transplant-related mortality and morbidity after allogeneic stem cell transplantation. Despite…”
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Bismuth-213 radioimmunotherapy with C595 anti-MUC1 monoclonal antibody in an ovarian cancer ascites model by Song, Emma Y., Qu, Chang F, Rizvi, Syed M.A., Raja, Chand, Beretov, Julia, Morgenstern, Alfred, Apostolidis, Christos, Bruchertseifer, Frank, Perkins, Alan, Allen, Barry J

“…Purpose: Control of ovarian cancer (OC) ascites remains a major objective in post-surgical treatment. The aim of this study was to investigate the effect of…”
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The cytokinesis-block micronucleus assay as a biological dosimeter for targeted alpha therapy by Song, Emma Y, Rizvi, Syed M A, Qu, Chang F, Raja, Chand, Yuen, Johnson, Li, Yong, Morgenstern, Alfred, Apostolidis, Christos, Allen, Barry J

“…Ionizing radiation causes structural chromosomal aberrations, a proportion of which give rise to chromosome fragments without spindle attachment organelles…”
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Preparation and testing of bevacizumab radioimmunoconjugates with Bismuth-213 and Bismuth-205 / Bismuth-206 by Rizvi, Syed M. Abbas, Song, Emma YanJun, Raja, Chand, Beretov, Julia, Morgenstern, Alfred, Apostolidis, Christos, Russell, Pamela J, Kearsley, John H, Abbas, K, Allen, Barry J

“…Bevacizumab, a humanized anti-VEGF monoclonal antibody has shown promise in various clinical trials. We report the development and testing of Bi-213 (an…”
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Mutagenesis induced by targeted alpha therapy using 213Bi-cDTPA-9.2.27 in lacZ transgenic mice by Allen, Barry J, So, Trina, Rizvi, Syed M. Abbas, Song, Emma, Fernandez, Harvey, Lutz-Mann, Louise

“…Targeted Alpha Therapy utilizes alpha-emitting radionuclides conjugated to monoclonal antibodies to allow specific irradiation of cancer cells whilst sparing…”
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Preclinical studies of bismuth-213 labeled plasminogen activator inhibitor type 2 (PAI2) in a prostate cancer nude mouse xenograft model by Rizvi, Syed M. Abbas, Li, Yong, Song, Emma YanJun, Qu, Chang Fa, Raja, Chand, Morgenstern, Alfred, Apostolidis, Christos, Allen, Barry J

“…Objectives: The key objective of the study was to determine the single and multiple dose toxicity and efficacy of Bismuth-213 labeled PAI2 based targeted alpha…”
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Inhibition of Micrometastatic Prostate Cancer Cell Spread in Animal Models By 213Bilabeled Multiple Targeted α Radioimmunoconjugates by YONG LI, SONG, Emma, RUSSELL, Pamela J, ABBAS RIZVI, Syed M, POWER, Carl A, BERETOV, Julia, RAJA, Chand, COZZI, Paul J, MORGENSTERN, Alfred, APOSTOLIDIS, Christos, ALLEN, BarryJ

“…Purpose: To investigate the therapeutic potential of 213 Bilabeled multiple targeted α-radioimmunoconjugates for treating prostate cancer (CaP) micrometastases…”
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El futuro de Junio by emma song

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Pre-clinical study of 213Bi labeled PAI2 for the control of micrometastatic pancreatic cancer by Qu, Chang F, Song, Emma Y, Li, Yong, Rizvi, Syed M A, Raja, Chand, Smith, Ross, Morgenstern, Alfred, Apostolidis, C, Allen, Barry J

“…The urokinase plasminogen activator (uPA) and its receptor (uPAR) are expressed by pancreatic cancer cells and can be targeted by the plasminogen activator…”
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Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs by Subramanian, Shruthi, Thoms, Julie A. I., Huang, Yizhou, Cornejo-Páramo, Paola, Koch, Forrest C., Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Chris, Woll, Petter S., Chacon-Fajardo, Diego, Beck, Dominik, Curtis, David J., Yehson, Kenneth, Antonenas, Vicki, O'Brien, Tracey, Trickett, Annette, Powell, Jason A., Lewis, Ian D., Pitson, Stuart M., Gandhi, Maher K., Lane, Steven W., Vafaee, Fatemeh, Wong, Emily S., Göttgens, Berthold, Alinejad-Rokny, Hamid, Wong, Jason W. H., Pimanda, John E.

“…•Heptad TF occupancy is highly dynamic across HSPC subsets and associated with cell-type–specific gene expression.•Enhancers with cell-type–specific heptad…”
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GSK‐3β Inhibition Promotes Engraftment of Ex Vivo‐Expanded Hematopoietic Stem Cells and Modulates Gene Expression by Ko, Kap‐Hyoun, Holmes, Tiffany, Palladinetti, Patricia, Song, Emma, Nordon, Robert, O'Brien, Tracey A., Dolnikov, Alla

“…Glycogen synthase kinase‐3β (GSK‐3β) has been identified as an important regulator of stem cell function acting through activation of the wingless (Wnt)…”
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Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions by Subramanian, Shruthi, Thoms, Julie A.I., Huang, Yizhou, Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Chris, Woll, Petter S, Fajardo, Diego Chacon, Beck, Dominik, Curtis, David J., Yehson, Kenneth, Antonenas, Vicki, Brien, Tracey O', Trickett, Annette, Powell, Jason, Pitson, Stuart M, Gandhi, Maher K., Cornejo, Paola, Wong, Emily, Lane, Steven W, Gottgens, Bertie, Rokny, Hamid Alinejad, Wong, Jason W.H, Pimanda, John E.

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Pharmacokinetics and toxicity of 213Bi-labeled PAI2 in preclinical targeted alpha therapy for cancer by Song, Emma Y., Rizvi, Syed M.A., Qu, Chang F, Raja, Chand, Brechbiel, Martin W, Morgenstern, Alfred, Apostolidis, Christos, Allen, Barry J

“…Objectives: The plasminogen activator inhibitor type 2 (PAI2) when labelled with 213Bi forms the 213Bi-PAI2 alpha conjugate (AC). This AC has been shown to be…”
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Glycogen Synthase Kinase‐3β Inhibition Preserves Hematopoietic Stem Cell Activity and Inhibits Leukemic Cell Growth by Holmes, Tiffany, O'Brien, Tracey A., Knight, Robert, Lindeman, Robert, Shen, Sylvie, Song, Emma, Symonds, Geoff, Dolnikov, Alla

“…Ex vivo expansion of cord blood cells generally results in reduced stem cell activity in vivo. Glycogen synthase kinase‐3β (GSK‐3β) regulates the degradation…”
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GSK-3β Inhibition Activates WNT, Delays Division and Preserves the Function in Hematopoietic Stem Cell by Dolnikov, Alla, Ko, Kap-hyoun, Song, Emma, Holmes, Tiffany, O'Brien, Tracey A

“…Wingless (Wnt) signaling appears to play an integral role in expansion and quiescence of stem and progenitor hematopoietic cell populations. To better…”
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Targeted alpha therapy for cancer by Allen, Barry J, Raja, Chand, Rizvi, Syed, Li, Yong, Tsui, Wendy, Zhang, David, Song, Emma, Qu, Chang Fa, Kearsley, John, Graham, Peter, Thompson, John

“…Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer…”
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