Search Results - "Song, BenBen"

Experimental and Computational Analysis of Protein Stabilization by Gly-to‑d‑Ala Substitution: A Convolution of Native State and Unfolded State Effects by Zou, Junjie, Song, Benben, Simmerling, Carlos, Raleigh, Daniel

“…The rational and predictable enhancement of protein stability is an important goal in protein design. Most efforts target the folded state, however stability…”
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Design and optimization of a new tube aeration device by Zhang, Chenglin, Song, Benben, Shan, Jianjun, Ni, Qi, Wu, Fan, Wang, Shiming

“…With the intensification and industrialization of aquaculture, there is an urgent need for new high-performance aeration devices and energy-saving aeration…”
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New candidate biomarkers in the female genital tract to evaluate microbicide toxicity by Fields, Scott, Song, Benben, Rasoul, Bareza, Fong, Julie, Works, Melissa G, Shew, Kenneth, Yiu, Ying, Mirsalis, Jon, D'Andrea, Annalisa

“…Vaginal microbicides hold great promise for the prevention of viral diseases like HIV, but the failure of several microbicide candidates in clinical trials has…”
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Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells by Liu, Shufeng, Zhao, Ting, Song, BenBen, Zhou, Jianhua, Wang, Tony T

“…Hepatitis C virus (HCV) poses a global threat to public health. HCV envelop protein E2 is the major component on the virus envelope, which plays an important…”
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Amyloid Formation by Pro-Islet Amyloid Polypeptide Processing Intermediates:  Examination of the Role of Protein Heparan Sulfate Interactions and Implications for Islet Amyloid Formation in Type 2 Diabetes by Meng, Fanling, Abedini, Andisheh, Song, Benben, Raleigh, Daniel P.

“…Amyloid formation has been implicated in a wide range of human diseases including Alzheimer's disease, Parkinson's disease, and type 2 diabetes. In type 2…”
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Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates by Song, Benben, Liu, Yashu, Parman, Toufan, Liu, Shufeng, Miller, Jennifer K, Liu, Xiaohua, Tanga, Mary J, Mirsalis, Jon

“…To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman…”
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Exploiting the Right Side of the Ramachandran Plot:  Substitution of Glycines by d-Alanine Can Significantly Increase Protein Stability by Anil, Burcu, Song, Benben, Tang, Yuefeng, Raleigh, Daniel P

“…A major goal of protein engineering is the enhancement of protein stability. Here we demonstrate a rational method for enhancing the stability of globular…”
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Design of a peptide inhibitor of tyrosine kinase 2 by Works, Melissa G, Song, Benben, Kibler, Patrick, Tanga, Mary J, Galande, Amit K, D'Andrea, Annalisa

“…Tyrosine kinase inhibitors show great promise as clinical therapies, but small molecule inhibitors that are available in the clinic and under development bind…”
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Efficiency of ultrafiltration/diafiltration in removing organic and elemental process equipment related leachables from biological therapeutics by Sun, Bin, Hadidi, Mahsa, Santiago Nuñez, Jose, Song, Benben, Tumambac, Gilbert E., Wong, Ken, Kalinowski, Gregor, Hathcock, James J.

“…In the production of biological therapeutics such as monoclonal antibodies (mAbs), ultrafiltration and diafiltration (UF/DF) are widely regarded as effective…”
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Residue Specific Resolution of Protein Folding Dynamics Using Isotope-Edited Infrared Temperature Jump Spectroscopy by Brewer, Scott H, Song, Benben, Raleigh, Daniel P, Dyer, R. Brian

“…A major difficulty in experimental studies of protein folding is the lack of nonperturbing, residue specific probes of folding. Here, we demonstrate the…”
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Aromatic Interactions Are Not Required for Amyloid Fibril Formation by Islet Amyloid Polypeptide but Do Influence the Rate of Fibril Formation and Fibril Morphology by Marek, Peter, Abedini, Andisheh, Song, BenBen, Kanungo, Mandakini, Johnson, Megan E, Gupta, Ruchi, Zaman, Warda, Wong, Stanislaus S, Raleigh, Daniel P

“…Amyloid formation has been implicated in a wide range of human diseases, and a diverse set of proteins is involved. There is considerable interest in…”
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An Enhanced β Turn in Water by Bomar, Martha G, Song, Benben, Kibler, Patrick, Kodukula, Krishna, Galande, Amit K

“…Aiming to design short linear peptides featuring strong intramolecular hydrogen bonds in water, a series of tetrapeptides based on the sequence…”
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Evaluation of functional activity and aggregation properties of hemopressin (1054.2) by Nayak, Surendra, Song, Benben, Kibler, Patrick, Adem, Amina, Endsley, Aaron, Jambunathan, Kalyani, Galande, Amit

“…Hemopressin is a naturally occurring nonapeptide derived from the α‐chain of hemoglobin that acts as an inverse agonist for the type‐1 cannabinoid (CB1)…”
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The Serine-Proline Turn: A Novel Hydrogen-Bonded Template for Designing Peptidomimetics by Song, Benben, Bomar, Martha G, Kibler, Patrick, Kodukula, Krishna, Galande, Amit K

“…Serine-Proline (SP) dipeptide motifs have been shown to form unique hydrogen-bonding patterns in protein crystal structures. Peptides were designed to mimic…”
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Serum Biomarkers Reveal Long-term Cardiac Injury in Isoproterenol-treated African Green Monkeys by Liu, Yashu, Parman, Toufan, Schneider, Bridget, Song, Benben, Galande, Amit K, Anderson, Dave, Mirsalis, Jon

“…The assessment of cardiac toxicity is a major challenge in both drug development and clinical trials, and numerous marketed pharmaceuticals have been removed…”
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Design of Short Linear Peptides That Show Hydrogen Bonding Constraints in Water by Song, Benben, Kibler, Patrick, Malde, Alpeshkumar, Kodukula, Krishna, Galande, Amit K

“…Using a combination of an aromatic amino acid, a homoserine side chain, and a d-amino acid, a series of linear tetrapeptides were designed that adopt an “Hse…”
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Site-specific Substitutions Eliminate Aggregation Properties of Hemopressin by Song, Benben, Kibler, Patrick D., Endsley, Aaron N., Nayak, Surendra K., Galande, Amit K., Jambunathan, Kalyani

“…Hemopressin is a naturally occurring and therapeutically relevant peptide with applications in hypertension, pain, addiction, and obesity. We had previously…”
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Ionic-Strength-Dependent Effects in Protein Folding:  Analysis of Rate Equilibrium Free-Energy Relationships and Their Interpretation by Song, Benben, Cho, Jae-Hyun, Raleigh, Daniel P

“…The traditional approach to studying protein folding involves applying a perturbation, usually denaturant or mutation, and determining the effect upon the free…”
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Competition between Intradomain and Interdomain Interactions: A Buried Salt Bridge Is Essential for Villin Headpiece Folding and Actin Binding by Packer, Laura E, Song, Benben, Raleigh, Daniel P, McKnight, C. James

“…Villin-type headpiece domains are ∼70 residue motifs that reside at the C-terminus of a variety of actin-associated proteins. Villin headpiece (HP67) is a…”
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Positive ϕ angles can strengthen hydrogen bonding in turn structures by Bomar, Martha G, Song, Benben, Kibler, Patrick, Kodukula, Krishna, Geysen, H. Mario, Galande, Amit K.

“…Satisfying hydrogen bond donors and acceptors through intramolecular hydrogen bonding is an important strategy for developing peptides with ‘drug‐like’…”
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