Search Results - "Sondey, John M"

New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides by Prugh, John D, Hartman, George D, Mallorga, Pierre J, McKeever, Brian M, Michelson, Stuart R, Murcko, Mark A, Schwam, Harvey, Smith, Robert L, Sondey, John M

“…A series of 5-substituted thieno[2,3-b]- and thieno[3,2-b)- and thieno[3,2-b)thiophene-2-sulfonamides was prepared and evaluated for topical ocular hypotensive…”
Get full text

Purification and characterization of human liver glycolate oxidase. Molecular weight, subunit, and kinetic properties by Schwam, Harvey, Michelson, Stuart, Randall, William C, Sondey, John M, Hirschmann, Ralph

Get full text

Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase by Scholz, Thomas H, Sondey, John M, Randall, William C, Schwam, Harvey, Thompson, Wayne J, Mallorga, Pierre J, Sugrue, Michael F, Graham, Samuel L

“…A series of sulfonylmethanesulfonamide derivatives is described, which are inhibitors of carbonic anhydrase (CA). The most potent of these is the racemic…”
Get full text

3-Substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors by Hunt, Cecilia A, Mallorga, Pierre J, Michelson, Stuart R, Schwam, Harvey, Sondey, John M, Smith, Robert L, Sugrue, Michael F, Shepard, Kenneth L

“…3-Aminoalkyl derivatives of thieno[2,3-b][1,4]thiazine-6-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. The compounds…”
Get full text

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Prugh, John D, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex…”
Get full text

4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors by Hartman, George D, Halczenko, Wasyl, Smith, Robert L, Sugrue, Michael F, Mallorga, Pierre J, Michelson, Stuart R, Randall, William C, Schwam, Harvey, Sondey, John M

“…A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic…”
Get full text

Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides by Shepard, Kenneth L, Graham, Samuel L, Hudcosky, Ronald J, Michelson, Stuart R, Scholz, Thomas H, Schwam, Harvey, Smith, Anthony M, Sondey, John M, Strohmaier, Kim M

“…For several decades a tantalizing goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase…”
Get full text

Dihydrofolate reductase: the amino acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia coli by Bennett, Carl D, Rodkey, John A, Sondey, John M, Hirschmann, Ralph

“…The determination of the amino acid sequence of the enzyme dihydrofolate reductase (5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3) from a mutant of…”
Get full text

Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity by Graham, Samuel L, Shepard, Kenneth L, Anderson, Paul S, Baldwin, John J, Best, Darryl B, Christy, Marcia E, Freedman, Mark B, Gautheron, Pierre, Habecker, Charles N

“…Derivatives of benzo[b]thiophene-2-sulfonamide were prepared to investigate their potential utility as topically active inhibitors of ocular carbonic…”
Get full text

Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides by Graham, Samuel L, Hoffman, Jacob M, Gautheron, Pierre, Michelson, Stuart R, Scholz, Thomas H, Schwam, Harvey, Shepard, Kenneth L, Smith, Anthony M, Smith, Robert L

“…Derivatives of benzofuran- and indole-2-sulfonamide were prepared for evaluation as topically active ocular hypotensive agents. These compounds were found to…”
Get full text