Search Results - "Sonders, Mark S"

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits by Tang, Guomei, Gudsnuk, Kathryn, Kuo, Sheng-Han, Cotrina, Marisa L., Rosoklija, Gorazd, Sosunov, Alexander, Sonders, Mark S., Kanter, Ellen, Castagna, Candace, Yamamoto, Ai, Yue, Zhenyu, Arancio, Ottavio, Peterson, Bradley S., Champagne, Frances, Dwork, Andrew J., Goldman, James, Sulzer, David

“…Developmental alterations of excitatory synapses are implicated in autism spectrum disorders (ASDs). Here, we report increased dendritic spine density with…”
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Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons by Steinkellner, Thomas, Zell, Vivien, Farino, Zachary J, Sonders, Mark S, Villeneuve, Michael, Freyberg, Robin J, Przedborski, Serge, Lu, Wei, Freyberg, Zachary, Hnasko, Thomas S

“…Parkinson's disease is characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). DA neurons in the ventral tegmental area…”
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Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice by Borgkvist, Anders, Avegno, Elizabeth M., Wong, Minerva Y., Kheirbek, Mazen A., Sonders, Mark S., Hen, Rene, Sulzer, David

“…Degeneration of dopamine (DA) neurons in Parkinson’s disease (PD) causes hypokinesia, but DA replacement therapy can elicit exaggerated voluntary and…”
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Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain by Freyberg, Zachary, Sonders, Mark S., Aguilar, Jenny I., Hiranita, Takato, Karam, Caline S., Flores, Jorge, Pizzo, Andrea B., Zhang, Yuchao, Farino, Zachary J., Chen, Audrey, Martin, Ciara A., Kopajtic, Theresa A., Fei, Hao, Hu, Gang, Lin, Yi-Ying, Mosharov, Eugene V., McCabe, Brian D., Freyberg, Robin, Wimalasena, Kandatege, Hsin, Ling-Wei, Sames, Dalibor, Krantz, David E., Katz, Jonathan L., Sulzer, David, Javitch, Jonathan A.

“…Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of…”
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Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain by Rodriguez, Pamela C., Pereira, Daniela B., Borgkvist, Anders, Wong, Minerva Y., Barnard, Candace, Sonders, Mark S., Zhang, Hui, Sames, Dalibor, Sulzer, David

“…We recently introduced fluorescent false neurotransmitters (FFNs) as optical tracers that enable the visualization of neurotransmitter release at individual…”
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Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation by Larsen, Mads Breum, Sonders, Mark S, Mortensen, Ole Valente, Larson, Gaynor A, Zahniser, Nancy R, Amara, Susan G

“…The serotonin transporter (SERT) is the principal mechanism for terminating serotonin (5-HT) signals in the nervous system and is a site of action for a…”
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New Fluorescent Substrate Enables Quantitative and High-Throughput Examination of Vesicular Monoamine Transporter 2 (VMAT2) by Hu, Gang, Henke, Adam, Karpowicz, Richard J, Sonders, Mark S, Farrimond, Frances, Edwards, Robert, Sulzer, David, Sames, Dalibor

“…Vesicular monoamine transporter 2 (VMAT2) is an essential component of the monoaminergic neurotransmission system in the brain as it transports monoamine…”
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Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits by Tang, Guomei, Gudsnuk, Kathryn, Kuo, Sheng-Han, Cotrina, Marisa L., Rosoklija, Gorazd, Sosunov, Alexander, Sonders, Mark S., Kanter, Ellen, Castagna, Candace, Yamamoto, Ai, Yue, Zhenyu, Arancio, Ottavio, Peterson, Bradley S., Champagne, Frances, Dwork, Andrew J., Goldman, James, Sulzer, David

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Mechanisms of neurotransmitter release by amphetamines: a review by Sulzer, David, Sonders, Mark S, Poulsen, Nathan W, Galli, Aurelio

“…Amphetamine and substituted amphetamines, including methamphetamine, methylphenidate (Ritalin), methylenedioxymethamphetamine (ecstasy), and the herbs khat and…”
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Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum by Pereira, Daniela B, Schmitz, Yvonne, Mészáros, József, Merchant, Paolomi, Hu, Gang, Li, Shu, Henke, Adam, Lizardi-Ortiz, José E, Karpowicz, Richard J, Morgenstern, Travis J, Sonders, Mark S, Kanter, Ellen, Rodriguez, Pamela C, Mosharov, Eugene V, Sames, Dalibor, Sulzer, David

“…The authors report the generation of fluorescent false neurotransmitter 200 (FFN200), a new optical probe for selectively monitoring monoamine exocytosis in…”
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Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain by Lee, Wei-Li, Westergaard, Xavier, Hwu, Christopher, Hwu, Jennifer, Fiala, Tomas, Lacefield, Clay, Boltaev, Umed, Mendieta, Adriana M., Lin, Lisa, Sonders, Mark S., Brown, Keaon R., He, Keer, Asher, Wesley B., Javitch, Jonathan A., Sulzer, David, Sames, Dalibor

“…The serotonergic transmitter system plays fundamental roles in the nervous system in neurotransmission, synaptic plasticity, pathological processes, and…”
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Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT by Aguilar, Jenny I., Dunn, Matthew, Mingote, Susana, Karam, Caline S., Farino, Zachary J., Sonders, Mark S., Choi, Se Joon, Grygoruk, Anna, Zhang, Yuchao, Cela, Carolina, Choi, Ben Jiwon, Flores, Jorge, Freyberg, Robin J., McCabe, Brian D., Mosharov, Eugene V., Krantz, David E., Javitch, Jonathan A., Sulzer, David, Sames, Dalibor, Rayport, Stephen, Freyberg, Zachary

“…The ability of presynaptic dopamine terminals to tune neurotransmitter release to meet the demands of neuronal activity is critical to neurotransmission…”
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Dissociation of high-affinity cocaine analog binding and dopamine uptake inhibition at the dopamine transporter by Wang, Wenfei, Sonders, Mark S, Ukairo, Okechukwu T, Scott, Helen, Kloetzel, Megan K, Surratt, Christopher K

“…Cocaine initiates its euphoric effects by binding to the dopamine transporter (DAT), blocking uptake of synaptic dopamine. It has been hypothesized that the…”
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Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor by Bunzow, J R, Sonders, M S, Arttamangkul, S, Harrison, L M, Zhang, G, Quigley, D I, Darland, T, Suchland, K L, Pasumamula, S, Kennedy, J L, Olson, S B, Magenis, R E, Amara, S G, Grandy, D K

“…The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. It is currently thought…”
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Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor by Wong, Erik H.F., Sonders, Mark S., Amara, Susan G., Tinholt, Paula M., Piercey, Montford F.P., Hoffmann, William P., Hyslop, Deborah K., Franklin, Stanley, Porsolt, Roger D., Bonsignori, Alberto, Carfagna, Nicola, McArthur, Robert A.

“…Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of imipramine, desipramine, and fluoxetine, and has improved side-effect…”
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Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants by Sonders, Mark S, Zhu, Si-Jia, Zahniser, Nancy R, Kavanaugh, Michael P, Amara, Susan G

“…Electrophysiological and pharmacological studies of a cloned human dopamine transporter (hDAT) were undertaken to investigate the mechanisms of transporter…”
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Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin by Fontana, Andréia C.K., Sonders, Mark S., Pereira-Junior, Olavo S., Knight, Matty, Javitch, Jonathan A., Rodrigues, Vanderlei, Amara, Susan G., Mortensen, Ole V.

“…The human blood fluke Schistosoma mansoni is the primary cause of schistosomiasis, a debilitating disease that affects 200 million individuals in over 70…”
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Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine by Busch, A E, Karbach, U, Miska, D, Gorboulev, V, Akhoundova, A, Volk, C, Arndt, P, Ulzheimer, J C, Sonders, M S, Baumann, C, Waldegger, S, Lang, F, Koepsell, H

“…Recently, we cloned the human cation transporter hOCT2, a member of a new family of polyspecific transporters from kidney, and demonstrated electrogenic uptake…”
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Channels in transporters by Sonders, Mark S, Amara, Susan G

“…Recent electrophysiological investigations of plasma membrane neurotransmitter transporters have shown that carriers can function in ways similar to ion…”
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How did the neurotransmitter cross the bilayer? A closer view by Sonders, Mark S, Quick, Matthias, Javitch, Jonathan A

“…Plasma membrane neurotransmitter transporters for monoamines, GABA, glycine and excitatory amino acids are homologous to two sizable families of bacterial…”
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