Search Results - "Sondermann, Peter"

Harnessing Fc receptor biology in the design of therapeutic antibodies by Sondermann, Peter, Szymkowski, David E

“…Highlights • The antibody Fc domain engages immune-activating, inhibitory, and homeostatic Fc receptors. • Fc domains are largely unaltered in existing…”
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General mechanism for modulating immunoglobulin effector function by Sondermann, Peter, Pincetic, Andrew, Maamary, Jad, Lammens, Katja, Ravetch, Jeffrey V.

“…Immunoglobulins recognize and clear microbial pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular activation…”
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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose by Ferrara, Claudia, Grau, Sandra, Jäger, Christiane, Sondermann, Peter, Brünker, Peter, Waldhauer, Inja, Hennig, Michael, Ruf, Armin, Rufer, Arne Christian, Stihle, Martine, Umaña, Pablo, Benz, Jörg

“…Antibody-mediated cellular cytotoxicity (ADCC), a key immune effector mechanism, relies on the binding of antigen–antibody complexes to Fcγ receptors expressed…”
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Mechanisms of Autoantibody-Induced Pathology by Ludwig, Ralf J, Vanhoorelbeke, Karen, Leypoldt, Frank, Kaya, Ziya, Bieber, Katja, McLachlan, Sandra M, Komorowski, Lars, Luo, Jie, Cabral-Marques, Otavio, Hammers, Christoph M, Lindstrom, Jon M, Lamprecht, Peter, Fischer, Andrea, Riemekasten, Gabriela, Tersteeg, Claudia, Sondermann, Peter, Rapoport, Basil, Wandinger, Klaus-Peter, Probst, Christian, El Beidaq, Asmaa, Schmidt, Enno, Verkman, Alan, Manz, Rudolf A, Nimmerjahn, Falk

“…Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to manifestation of autoimmune diseases, such as…”
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Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells by Lustig, Marta, Chan, Chilam, Jansen, J H Marco, Bräutigam, Maria, Kölling, Max A, Gehlert, Carina Lynn, Baumann, Niklas, Mester, Simone, Foss, Stian, Andersen, Jan Terje, Bastian, Lorenz, Sondermann, Peter, Peipp, Matthias, Burger, Renate, Leusen, Jeanette H W, Valerius, Thomas

“…Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms which promote tumor growth and progression. Specifically, the…”
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Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies by Schnueriger, Alfred, Grau, Roger, Sondermann, Peter, Schreitmueller, Thomas, Marti, Stefan, Zocher, Marcel

“…► Consistent assessment of ADCC activity of therapeutic antibodies is technically challenging due to donor-dependent variation of primary effector cells. ►…”
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Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc by Sondermann, Peter, Pincetic, Andrew, Maamary, Jad, Lammens, Katja, Ravetch, Jeffrey V

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Structure of the Streptococcal Endopeptidase IdeS, a Cysteine Proteinase with Strict Specificity for IgG by Wenig, Katja, Chatwell, Lorenz, von Pawel-Rammingen, Ulrich, Björck, Lars, Huber, Robert, Sondermann, Peter

“…Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme…”
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The FcγR/IgG Interaction as Target for the Treatment of Autoimmune Diseases by Sondermann, Peter

“…FcγRs are a crucial component of the antibody response as they mediate the cellular effector functions in response to IgG-containing immune complexes (ICs)…”
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The Fc[gamma]R/IgG Interaction as Target for the Treatment of Autoimmune Diseases by Sondermann, Peter

“…Issue Title: Antibodies: Assembly to Secretion, and Receptors as Therapeutic Targets Proceedings from the 4th International Forum on Immunology Research FcγRs…”
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FcγRIIIa chromatography to enrich a-fucosylated glycoforms and assess the potency of glycoengineered therapeutic antibodies by Freimoser–Grundschober, Anne, Rueger, Petra, Fingas, Felix, Sondermann, Peter, Herter, Sylvia, Schlothauer, Tilman, Umana, Pablo, Neumann, Christiane

“…•Fully fucosylated, mono-fucosylated and a-fucosylated IgGs were separated.•Mono- and a-fucosylated IgGs had equivalent biological activity.•Relative peak area…”
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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity by Mössner, Ekkehard, Brünker, Peter, Moser, Samuel, Püntener, Ursula, Schmidt, Carla, Herter, Sylvia, Grau, Roger, Gerdes, Christian, Nopora, Adam, van Puijenbroek, Erwin, Ferrara, Claudia, Sondermann, Peter, Jäger, Christiane, Strein, Pamela, Fertig, Georg, Friess, Thomas, Schüll, Christine, Bauer, Sabine, Dal Porto, Joseph, Del Nagro, Christopher, Dabbagh, Karim, Dyer, Martin J.S., Poppema, Sibrand, Klein, Christian, Umaña, Pablo

“…CD20 is an important target for the treatment of B-cell malignancies, including non-Hodgkin lymphoma as well as autoimmune disorders. B-cell depletion therapy…”
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The Carbohydrate at Fc gamma RIIIa Asn-162: An element required for high affinity binding to non-fucosylated IgG glycoforms by Ferrara, Claudia, Stuart, Fiona, Sondermann, Peter, Bruenker, Peter, Umana, Pablo

“…Fc gamma RIIIa plays a prominent role in the elimination of tumor cells by antibody-based cancer therapies. Non-fucosylated bisected IgGs bind this receptor…”
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Abstract 3125: TCX-101, a novel antibody-drug conjugate targeting a tumor-associated carbohydrate antigen for the treatment of solid tumors by Gomes, Fausto G., Muraca, Francesco, Moreira, Gustavo M. Schmidt Garcia, Rösch, Kathrin, Bräutigam, Maria, Sondermann, Peter, Ocker, Matthias

“…Abstract Tumor-associated carbohydrate antigens (TACAs) are short oligosaccharides expressed on the surface of cancer cells and play key roles in cellular…”
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An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo by Lohse, Stefan, Meyer, Saskia, Meulenbroek, Laura A P M, Jansen, J H Marco, Nederend, Maaike, Kretschmer, Anna, Klausz, Katja, Möginger, Uwe, Derer, Stefanie, Rösner, Thies, Kellner, Christian, Schewe, Denis, Sondermann, Peter, Tiwari, Sanjay, Kolarich, Daniel, Peipp, Matthias, Leusen, Jeanette H W, Valerius, Thomas

“…Antibodies of IgA isotype effectively engage myeloid effector cells for cancer immunotherapy. Here, we describe preclinical studies with an Fc engineered…”
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The 3.2- crystal structure of the human IgG1 Fc fragment-FcγRIII complex by Sondermann, Peter, Huber, Robert, Oosthuizen, Vaughan, Jacob, Uwe

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Recombinant Soluble CD32 Suppresses Disease Progression in Experimental Epidermolysis Bullosa Acquisita by Iwata, Hiroaki, Pipi, Elena, Möckel, Nicole, Sondermann, Peter, Vorobyev, Artem, van Beek, Nina, Zillikens, Detlef, Ludwig, Ralf J.

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Crystal structure of the soluble form of the human Fcγ-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 Å resolution by Sondermann, Peter, Huber, Robert, Jacob, Uwe

“…Fcγ‐receptors (FcγRs) represent the link between the humoral and cellular immune responses. Via the binding to FcγR‐positive cells, immunocomplexes trigger…”
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Role of Oligosaccharide Residues of IgG1-Fc in FcγRIIb Binding by Mimura, Yusuke, Sondermann, Peter, Ghirlando, Rodolfo, Lund, John, Young, Stephen P., Goodall, Margaret, Jefferis, Roy

“…Engagement of Fcγ receptors (FcγRs) with the Fc region of IgG elicits immune responses by leukocytes. The recent crystal structure of FcγRIII in complex with…”
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Pharmacokinetics and myeloid effector cell engagement of an engineered IgA antibody against the epidermal growth factor receptor by Valerius, Thomas, Lohse, Stefan, Meyer, Saskia, Jansen, Marco J.H., Meulenbroek, Laura A.P., Nederend, Maaike, Möginger, Uwe, Kretschmer, Anna, Klausz, Katja, Derer, Stefanie, Sondermann, Peter, Kolarich, Daniel, Peipp, Matthias, Leusen, Jeanette H. W., Gramatzki, Martin

“…Abstract only…”
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