Anxiogenic activity of Myristica fragrans seeds

In the present study, the n-hexane extract of Myristica fragrans (MF) seeds, acetone-insoluble part of the n-hexane extract (AIMF) and trimyristin (TM) were assessed for their anxiogenic activity. The MF (10 and 30 mg/kg), AIMF (30, 100, and 300 mg/kg), and TM (10, 30, and 100 mg/kg) administered in...

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Published in:	Pharmacology, biochemistry and behavior Vol. 71; no. 1; pp. 239 - 244
Main Authors:	Sonavane, G.S, Sarveiya, V.P, Kasture, V.S, Kasture, S.B
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-01-2002 Elsevier Science
Subjects:	Animals Anti-Anxiety Agents - pharmacology Anti-Anxiety Agents - therapeutic use Anxiety - chemically induced Anxiety - drug therapy Anxiogenic Biological and medical sciences Buspirone Diazepam Exploratory Behavior - drug effects Exploratory Behavior - physiology General pharmacology Hexanes - isolation & purification Hexanes - pharmacology Male Medical sciences Mice Myristica - chemistry Myristica fragrans Ondansetron Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Seeds - chemistry Triglycerides - isolation & purification Triglycerides - pharmacology Trimyristin Myristica fragrans Buspirone Anxiogenic Trimyristin Diazepam Ondansetron Agonist Intraperitoneal administration Psychotropic Toxicity Anxiety disorder Extract 5-HT1A Serotonine receptor Anxiety Antagonist Mechanism of action Pharmacognosy Rodentia Biological activity Open field behavior Locomotion Vertebrata Chemotherapy Mammalia Treatment Tranquillizer Mouse Animal 5-HT3 Serotonine receptor Plant origin Gabaergic receptor A
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Summary:	In the present study, the n-hexane extract of Myristica fragrans (MF) seeds, acetone-insoluble part of the n-hexane extract (AIMF) and trimyristin (TM) were assessed for their anxiogenic activity. The MF (10 and 30 mg/kg), AIMF (30, 100, and 300 mg/kg), and TM (10, 30, and 100 mg/kg) administered intraperitoneally exhibited anxiogenic activity in elevated plus-maze (EPM) paradigm. The open-field test and hole-board test were also used to assess anxiogenic activity of AIMF and TM. In the EPM test, MF, AIMF, and TM decreased the time spent by mice in the open arm and the entries in the open arm. Further, the effect of diazepam (1 mg/kg ip), serotonin 5-HT3 receptor antagonist, ondansetron (1 mg/kg ip), and 5-HT1A receptor agonist, buspirone (1 mg/kg ip), on the occupancy in open arm and entries in open arm was significantly reduced by TM. In the open-field test, AIMF as well as TM reduced the number of rearing and locomotion. Both TM and AIMF reduced the number of head pock in the hole-board test. Inhibition of anxiolytic activity of ondansetron (5-HT3 receptor antagonist), buspirone (5-HT1A receptor agonist), and diazepam [acting on γ-aminobutyric acid (GABAA) receptor] suggests a nonspecific anxiogenic activity of TM and also a link between 5-HT and GABA systems in the anxiogenic activity of TM.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0091-3057 1873-5177
DOI:	10.1016/S0091-3057(01)00660-8