Search Results - "Sonatore, Lisa M"

A Peptide-Based Fluorescence Resonance Energy Transfer Assay for Bacillus anthracis Lethal Factor Protease by Cummings, Richard T., Salowe, Scott P., Cunningham, Barry R., Wiltsie, Judyann, Park, Young Whan, Sonatore, Lisa M., Wisniewski, Douglas, Douglas, Cameron M., Hermes, Jeffrey D., Scolnick, Edward M.

“…A fluorescence resonance energy transfer assay has been developed for monitoring Bacillus anthracis lethal factor (LF) protease activity. A fluorogenic 16-mer…”
Get full text

The Catalytic Flexibility of tRNAIle-lysidine Synthetase Can Generate Alternative tRNA Substrates for Isoleucyl-tRNA Synthetase by Salowe, Scott P., Wiltsie, Judyann, Hawkins, Julio C., Sonatore, Lisa M.

“…Bacteria decode the isoleucine codon AUA using a tRNA species that is posttranscriptionally modified at the wobble position of the anticodon with a…”
Get full text

Discovery of N‑[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia by Debenham, John S, Madsen-Duggan, Christina, Clements, Matthew J, Walsh, Thomas F, Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P, Sonatore, Lisa M, Hajdu, Richard, Milligan, James A, Visco, Denise M, Zhou, Dan, Lingham, Russell B, Stickens, Dominique, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Pang, Jianmei, Miller, Randy R, Sherer, Edward C, Hale, Jeffrey J

“…The discovery of novel 4-hydroxy-2-(heterocyclic)­pyrimidine-5-carboxamide inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) is described…”
Get full text

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC) by Yu, Yang, Wu, Zhicai, Shi, Zhi-Cai, He, Shuwen, Lai, Zhong, Cernak, Timothy A., Vachal, Petr, Liu, Min, Liu, Jian, Hong, Qingmei, Jian, Tianying, Guiadeen, Deodial, Krikorian, Arto, Sperbeck, Donald M., Verras, Andreas, Sonatore, Lisa M., Murphy, Beth A., Wiltsie, Judyann, Chung, Christine C., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., De Vita, Robert J., Pinto, Shirly, Nargund, Ravi P.

“…[Display omitted] The parallel medicinal chemistry (PMC) was effectively applied to accelerate the optimization of diacylglycerol O-acyltransferase I (DGAT-1)…”
Get full text

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program by Zhang, Ting, Liu, Yong, Yang, Xianshu, Martin, Gary E, Yao, Huifang, Shang, Jackie, Bugianesi, Randal M, Ellsworth, Kenneth P, Sonatore, Lisa M, Nizner, Peter, Sherer, Edward C, Hill, Susan E, Knemeyer, Ian W, Geissler, Wayne M, Dandliker, Peter J, Helmy, Roy, Wood, Harold B

“…A potent and selective Factor IXa (FIXa) inhibitor was subjected to a series of liver microsomal incubations, which generated a number of metabolites. Using…”
Get full text

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia by Vachal, Petr, Miao, Shouwu, Pierce, Joan M, Guiadeen, Deodial, Colandrea, Vincent J, Wyvratt, Matthew J, Salowe, Scott P, Sonatore, Lisa M, Milligan, James A, Hajdu, Richard, Gollapudi, Anantha, Keohane, Carol A, Lingham, Russell B, Mandala, Suzanne M, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Steinhuebel, Dietrich, Kieczykowski, Gerard R, Fleitz, Fred J, Chapman, Kevin, Athanasopoulos, John, Adam, Gregory, Akyuz, Can D, Jena, Dhirendra K, Lusen, Jeffrey W, Meng, Juncai, Stein, Benjamin D, Xia, Lei, Sherer, Edward C, Hale, Jeffrey J

“…The discovery of 1,3,8-triazaspiro[4.5]­decane-2,4-diones (spirohydantoins) as a structural class of pan-inhibitors of the prolyl hydroxylase (PHD) family of…”
Get full text

Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety by He, Shuwen, Lai, Zhong, Hong, Qingmei, Shang, Jackie, Reibarkh, Mikhail, Kuethe, Jeffrey T., Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Verras, Andreas, Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.

“…Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of…”
Get full text

Development of a novel class of potent and selective FIXa inhibitors by Zhang, Ting, Andre, Patrick, Bateman, Thomas J., Chen, Yi-Heng, Desai, Kunal, Ellsworth, Kenneth, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Meng, Dongfang, Parker, Dann L., Qian, Xiaoxia, Reichert, Paul, Sherer, Edward C., Shu, Min, Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Nolting, Andrew F., Orr, Robert, Campeau, Louis-Charles, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Wood, Harold B.

“…[Display omitted] Using structure based drug design (SBDD), a novel class of potent coagulation Factor IXa (FIXa) inhibitors was designed and synthesized. High…”
Get full text

Identification of DGAT2 Inhibitors Using Mass Spectrometry by Song, Xuelei S, Zhang, Jiaping, Chen, Xun, Palyha, Oksana, Chung, Christine, Sonatore, Lisa M, Wilsie, Larissa, Stout, Steven, McLaren, David G, Taggart, Andrew, Imbriglio, Jason E, Pinto, Shirly, Garcia-Calvo, Margarita, Addona, George H

“…Mass spectrometry offers significant advantages over other detection technologies in the areas of hit finding, hit validation, and medicinal chemistry compound…”
Get more information

Development of a novel tricyclic class of potent and selective FIXa inhibitors by Meng, Dongfang, Andre, Patrick, Bateman, Thomas J., Berger, Richard, Chen, Yi-Heng, Desai, Kunal, Dewnani, Sunita, Ellsworth, Kenneth, Feng, Daming, Geissler, Wayne M., Guo, Liangqin, Hruza, Alan, Jian, Tianying, Li, Hong, Metzger, Joe, Parker, Dann L., Reichert, Paul, Sherer, Edward C., Smith, Cameron J., Sonatore, Lisa M., Tschirret-Guth, Richard, Wu, Jane, Xu, Jiayi, Zhang, Ting, Campeau, Louis-Charles, Orr, Robert, Poirier, Marc, McCabe-Dunn, Jamie, Araki, Kazuto, Nishimura, Teruyuki, Sakurada, Isao, Hirabayashi, Tomokazu, Wood, Harold B.

“…[Display omitted] Using structure based drug design, a novel class of potent coagulation factor IXa (FIXa) inhibitors was designed and synthesized. High…”
Get full text

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety by He, Shuwen, Hong, Qingmei, Lai, Zhong, Yang, David X, Ting, Pauline C, Kuethe, Jeffrey T, Cernak, Timothy A, Dykstra, Kevin D, Sperbeck, Donald M, Wu, Zhicai, Yu, Yang, Yang, Ginger X, Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D, Sonatore, Lisa M, Wiltsie, Judyann, Liu, Jinqi, Gorski, Judith N, Chung, Christine C, Gibson, Jack T, Lisnock, JeanMarie, Xiao, Jianying, Wolff, Michael, Tong, Sharon X, Madeira, Maria, Karanam, Bindhu V, Shen, Dong-Ming, Balkovec, James M, Pinto, Shirly, Nargund, Ravi P, DeVita, Robert J

“…We report the discovery of a novel series of DGAT1 inhibitors in the benzimidazole class with a piperdinyl-oxy-cyclohexanecarboxylic acid moiety. This novel…”
Get full text

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety by He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W, Ting, Pauline C, Kuethe, Jeffrey T, Yang, Ginger X, Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D, Sperbeck, Donald M, Sonatore, Lisa M, Wiltsie, Judyann, Chung, Christine C, Gibson, Jack T, Lisnock, JeanMarie, Murphy, Beth A, Gorski, Judith N, Liu, Jinqi, Chen, Dunlu, Chen, Xiaoli, Wolff, Michael, Tong, Sharon X, Madeira, Maria, Karanam, Bindhu V, Shen, Dong-Ming, Balkovec, James M, Pinto, Shirly, Nargund, Ravi P, DeVita, Robert J

“…We report the design and synthesis of a series of novel DGAT1 inhibitors in the benzimidazole class with a pyridyl-oxy-cyclohexanecarboxylic acid moiety. In…”
Get full text

Disubstituted pyrimidines as Lck inhibitors by Hunt, Julianne A., Beresis, Richard T., Goulet, Joung L., Holmes, Mark A., Hong, Xinfang J., Kovacs, Ernest, Mills, Sander G., Ruzek, Rowena D., Wong, Frederick, Hermes, Jeffrey D., Park, Young-Whan, Salowe, Scott P., Sonatore, Lisa M., Wu, Lin, Woods, Andrea, Zaller, Dennis M., Sinclair, Peter J.

“…Compound 4 was found to be a potent inhibitor of Lck activity (IC 50 = 0.1 nM) and cellular IL2 release (IC 50 = 8 nM). We have developed a family of…”
Get full text

The Utility of FK506-Binding Protein as a Fusion Partner in Scintillation Proximity Assays: Application to SH2 Domains by Sonatore, Lisa M., Wisniewski, Doug, Frank, Lori J., Cameron, Patricia M., Hermes, Jeffrey D., Marcy, Alice I., Salowe, Scott P.

“…Methodology has been developed which gives a specific measure of the interaction of an SH2 domain with a phosphopeptide ligand using scintillation proximity…”
Get full text