Search Results - "Sonaje, Kiran"

A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery by Chen, Mei-Chin, Sonaje, Kiran, Chen, Ko-Jie, Sung, Hsing-Wen

“…Abstract Success in the oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients who must routinely receive…”
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Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin by Kandekar, Somnath G, Singhal, Mayank, Sonaje, Kiran B, Kalia, Yogeshvar N

“…: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma…”
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Opening of Epithelial Tight Junctions and Enhancement of Paracellular Permeation by Chitosan: Microscopic, Ultrastructural, and Computed-Tomographic Observations by Sonaje, Kiran, Chuang, Er-Yuan, Lin, Kun-Ju, Yen, Tzu-Chen, Su, Fang-Yi, Tseng, Michael T, Sung, Hsing-Wen

“…This study investigates the effects of chitosan (CS) on the opening of epithelial tight junctions (TJs) and paracellular transport at microscopic,…”
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Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery by Su, Fang-Yi, Lin, Kun-Ju, Sonaje, Kiran, Wey, Shiaw-Pyng, Yen, Tzu-Chen, Ho, Yi-Cheng, Panda, Nilendu, Chuang, Er-Yuan, Maiti, Barnali, Sung, Hsing-Wen

“…Abstract Complexing agents such as diethylene triamine pentaacetic acid (DTPA) are known to disrupt intestinal tight junctions and inhibit intestinal proteases…”
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In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery by Sonaje, Kiran, Lin, Yu-Hsin, Juang, Jyuhn-Huarng, Wey, Shiaw-Pyng, Chen, Chiung-Tong, Sung, Hsing-Wen

“…Abstract A variety of approaches have been studied in the past to overcome the problems encountered with the oral delivery of insulin, but with little success…”
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Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins by Sonaje, Kiran, Lin, Kun-Ju, Tseng, Michael T, Wey, Shiaw-Pyng, Su, Fang-Yi, Chuang, Er-Yuan, Hsu, Chia-Wei, Chen, Chiung-Tong, Sung, Hsing-Wen

“…Abstract Recently, we reported a pH-responsive nanoparticle (NP) system shelled with chitosan (CS), which could effectively increase the oral absorption of…”
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Iontosomes: Electroresponsive Liposomes for Topical Iontophoretic Delivery of Chemotherapeutics to the Buccal Mucosa by Sonaje, Kiran, Tyagi, Vasundhara, Chen, Yong, Kalia, Yogeshvar N

“…The targeted local delivery of anticancer therapeutics offers an alternative to systemic chemotherapy for oral cancers not amenable to surgical excision…”
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Self-Assembled pH-Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs by Sonaje, Kiran, Lin, Kun-Ju, Wang, Jiun-Jie, Mi, Fwu-Long, Chen, Chiung-Tong, Juang, Jyuhn-Huarng, Sung, Hsing-Wen

“…The oral route is considered to be the most convenient and comfortable means of drug administration for patients. Nevertheless, oral administration of…”
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The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo by Nguyen, Ho-Ngoc, Wey, Shiaw-Pyng, Juang, Jyuhn-Huarng, Sonaje, Kiran, Ho, Yi-Cheng, Chuang, Er-Yuan, Hsu, Chia-Wei, Yen, Tzu-Chen, Lin, Kun-Ju, Sung, Hsing-Wen

“…Abstract Exendin-4 is a potent insulinotropic agent in diabetes patients; however, its therapeutic utility is limited due to the frequent injections required…”
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Oral Delivery of Peptide Drugs Using Nanoparticles Self-Assembled by Poly(γ-glutamic acid) and a Chitosan Derivative Functionalized by Trimethylation by Mi, Fwu-Long, Wu, Yong-Yi, Lin, Yu-Hsin, Sonaje, Kiran, Ho, Yi-Cheng, Chen, Chiung-Tong, Juang, Jyuhn-Huarng, Sung, Hsing-Wen

“…In the study, chitosan (CS) was conjugated with trimethyl groups for the synthesis of N-trimethyl chitosan (TMC) polymers with different degrees of…”
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pH-Responsive Nanoparticles Shelled with Chitosan for Oral Delivery of Insulin: From Mechanism to Therapeutic Applications by Sung, Hsing-Wen, Sonaje, Kiran, Liao, Zi-Xian, Hsu, Li-Wen, Chuang, Er-Yuan

“…Despite advances in drug-delivery technologies, successful oral administration of protein drugs remains an elusive challenge. When protein drugs are…”
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Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules by Chen, Mei-Chin, Mi, Fwu-Long, Liao, Zi-Xian, Hsiao, Chun-Wen, Sonaje, Kiran, Chung, Min-Fan, Hsu, Li-Wen, Sung, Hsing-Wen

“…Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal absorption enhancer of therapeutic macromolecules, owing to its…”
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Correction to “Oral Delivery of Peptide Drugs Using Nanoparticles Self-Assembled by Poly(γ-glutamic acid) and a Chitosan Derivative Functionalized by Trimethylation” by Mi, Fwu-Long, Wu, Yong-Yi, Lin, Yu-Hsin, Sonaje, Kiran, Ho, Yi-Cheng, Chen, Chiung-Tong, Juang, Jyuhn-Huarng, Sung, Hsing-Wen

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Targeted cutaneous delivery of etanercept using Er:YAG fractional laser ablation by del Río-Sancho, Sergio, Lapteva, Maria, Sonaje, Kiran, Böhler, Christof, Ling, Vincent, Boehncke, Wolf-Henning, Kalia, Yogeshvar N.

“…[Display omitted] The aim was to investigate the feasibility of using Er:YAG fractional laser ablation to enable topical cutaneous delivery of etanercept…”
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An architecturally rational hemostat for rapid stopping of massive bleeding on anticoagulation therapy by Lee, Vivian K, Lee, Taewoo, Ghosh, Amrit, Saha, Tanmoy, Bais, Manish V, Bharani, Kala Kumar, Chag, Milan, Parikh, Keyur, Bhatt, Parloop, Namgung, Bumseok, Venkataramanan, Geethapriya, Agrawal, Animesh, Sonaje, Kiran, Mavely, Leo, Sengupta, Shiladitya, Mashelkar, Raghunath Anant, Jang, Hae Lin

“…Hemostatic devices are critical for managing emergent severe bleeding. With the increased use of anticoagulant therapy, there is a need for next-generation…”
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Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery by Sonaje, Kiran, Chen, Yi-Jia, Chen, Hsin-Lung, Wey, Shiaw-Pyng, Juang, Jyuhn-Huarng, Nguyen, Ho-Ngoc, Hsu, Chia-Wei, Lin, Kun-Ju, Sung, Hsing-Wen

“…Abstract A pH-sensitive nanoparticle (NP) system composed of chitosan and poly(γ-glutamic acid) was prepared for the oral delivery of insulin. The…”
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Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection by Sonaje, Kiran, Lin, Kun-Ju, Wey, Shiaw-Pyng, Lin, Che-Kuan, Yeh, Tzyy-Harn, Nguyen, Ho-Ngoc, Hsu, Chia-Wei, Yen, Tzu-Chen, Juang, Jyuhn-Huarng, Sung, Hsing-Wen

“…Abstract In this study, we report the biodistribution of aspart-insulin, a rapid-acting insulin analogue, following oral or subcutaneous (SC) administration to…”
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Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs by Lin, Yu-Hsin, Sonaje, Kiran, Lin, Kurt M., Juang, Jyuhn-Huarng, Mi, Fwu-Long, Yang, Han-Wen, Sung, Hsing-Wen

“…pH-Responsive nanoparticles composed of chitosan (CS) and poly-γ-glutamic acid (γ-PGA) blended with tripolyphosphate (TPP) and MgSO 4 (multi-ion-crosslinked…”
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Fractional Laser Ablation for the Cutaneous Delivery of Triamcinolone Acetonide from Cryomilled Polymeric Microparticles: Creating Intraepidermal Drug Depots by Singhal, Mayank, del Río-Sancho, Sergio, Sonaje, Kiran, Kalia, Yogeshvar N

“…The efficacy of some dermatological therapies might be improved by the use of “high dose” intraepidermal drug reservoir systems that enable sustained and…”
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The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin by Chen, Mei-Chin, Wong, Hen-Sheng, Lin, Kun-Ju, Chen, Hsin-Lung, Wey, Shiaw-Pyng, Sonaje, Kiran, Lin, Yu-Hsin, Chu, Che-Yi, Sung, Hsing-Wen

“…Abstract Heparin is a potent anticoagulant; however, it is poorly absorbed in the gastrointestinal tract. In this study, we developed a nanoparticle (NP)…”
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