Search Results - "Sonabend, A"

Convection-Enhanced Delivery by Mehta, A. M., Sonabend, A. M., Bruce, J. N.

“…Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics…”
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A Multiparametric Model for Mapping Cellularity in Glioblastoma Using Radiographically Localized Biopsies by Chang, P D, Malone, H R, Bowden, S G, Chow, D S, Gill, B J A, Ung, T H, Samanamud, J, Englander, Z K, Sonabend, A M, Sheth, S A, McKhann, 2nd, G M, Sisti, M B, Schwartz, L H, Lignelli, A, Grinband, J, Bruce, J N, Canoll, P

“…The complex MR imaging appearance of glioblastoma is a function of underlying histopathologic heterogeneity. A better understanding of these correlations,…”
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Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo by Tyler, M A, Ulasov, I V, Sonabend, A M, Nandi, S, Han, Y, Marler, S, Roth, J, Lesniak, M S

“…Adenoviral oncolytic virotherapy represents an attractive treatment modality for central nervous system (CNS) neoplasms. However, successful application of…”
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Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo by Ulasov, I V, Sonabend, A M, Nandi, S, Khramtsov, A, Han, Y, Lesniak, M S

“…Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect…”
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Craniotomy versus biopsy for primary CNS lymphoma: An institutional series and nationwide NCDB‐PUF and SEER database study by Iwamoto, F.M., Rae, A., Mehta, A., Cloney, M., Sonabend, A.

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Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats by Sonabend, A M, Ulasov, I V, Han, Y, Rolle, C E, Nandi, S, Cao, D, Tyler, M A, Lesniak, M S

“…Conditionally replicative adenoviruses (CRAds) are often evaluated in mice; however, normal and cancerous mouse tissues are poorly permissive for human CRAds…”
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Intrahepatic DNA Vaccination: Unexpected Increased Resistance Against Murine Cysticercosis Induced by Non-specific Enhanced Immunity by Cruz-Revilla, C, Sonabend, A. M, Rosas, G, Toledo, A, Meneses, G, Lopez-Casillas, F, Hernández, B, Fragoso, G, Sciutto, E

“…Experimental murine cysticercosis caused by Taenia crassiceps has proved to be a useful model with which to test the efficacy of new vaccine candidates and…”
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OS08.6.A Novel role of ARF4-mediated retrograde trafficking as a driver of chemoresistance in GBM by Budhiraja, S, Baisiwala, S, Perrault, E, Cho, S, Dara, G, Nandoliya, K, Zolp, A, Chen, L, Dmello, C, Park, C, Sonabend, A, Ahmed, A

“…Abstract Background Glioblastoma (GBM) is the most common type of adult malignant brain tumor, with a median survival of only 21 months. This is partly due to…”
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OS07.3.A Phase 1/2 clinical trial of blood-brain barrier opening with the SonoCloud-9 implantable ultrasound device in recurrent glioblastoma patients receiving IV carboplatin by Idbaih, A, Sonabend, A, Stupp, R, Chinot, O, Dufour, H, Ducray, F, Menei, P, de Groot, J, Desseaux, C, Carpentier, A

“…Abstract Background Low intensity pulsed ultrasound (LIPU) in combination with microbubbles is a promising approach for brain drug delivery. A phase 1/2…”
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JS07.4.A REGIONAL B-CELL MEDIATED IMMUNOSUPPRESSION IDENTIFIED THROUGH SPATIAL AND SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF CHORDOMA by Kada Benotmane, J, Arrieta, V A, Zhao, J, Hou, D, Katz, J, Pandey, S, Cholak, M, Sonabend, A, Horbinski, C, Miska, J, Stupp, R, Lesniak, M, Heiland, D, Chang, C

“…Abstract BACKGROUND Chordomas, rare indolent neoplasms, mainly occur in the skull base or lower spine. Therapies, including surgery and radiotherapy, often…”
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KS05.6.A T-CELL THERAPY COMBINED WITH LOW-INTENSITY PULSED FOCUSED ULTRASOUND, MICROBUBBLES AND POLY-ICLC PROMOTES THE PRESENTATION OF BRAIN-DERIVED ANTIGENS, BREAKING CNS TOLERANCE AND INDUCING ACTIVE T-CELL RESPONSES by Gallus, M, Yamamichi, A, Andres Arrieta, V, Saijo, A, Chuntova, P, Haegelin, J, Phyu, S, Phung, L, Long, J, Lakshmanachetty, S, Nejo, T, Okada, K, Chen, L, Habashy, K, Gould, A, Amidei, C, Chang, C, Stupp, R, Canney, M, Sonabend, A, Okada, H

“…Abstract BACKGROUND Immunotherapies targeting glioma, such as chimeric antigen receptor (CAR) T cell therapies, offer new therapeutic opportunities; however,…”
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Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas by Baldock, Anne L, Ahn, Sunyoung, Rockne, Russell, Johnston, Sandra, Neal, Maxwell, Corwin, David, Clark-Swanson, Kamala, Sterin, Greg, Trister, Andrew D, Malone, Hani, Ebiana, Victoria, Sonabend, Adam M, Mrugala, Maciej, Rockhill, Jason K, Silbergeld, Daniel L, Lai, Albert, Cloughesy, Timothy, McKhann, 2nd, Guy M, Bruce, Jeffrey N, Rostomily, Robert C, Canoll, Peter, Swanson, Kristin R

“…Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging…”
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Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma by Sonabend, Adam M, Carminucci, Arthur S, Amendolara, Benjamin, Bansal, Mukesh, Leung, Richard, Lei, Liang, Realubit, Ronald, Li, Hai, Karan, Charles, Yun, Jonathan, Showers, Christopher, Rothcock, Robert, O, Jane, Califano, Andrea, Canoll, Peter, Bruce, Jeffrey N

“…Glioblastoma subtypes have been defined based on transcriptional profiling, yet personalized care based on molecular classification remains unexploited…”
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Prolonged intracerebral convection-enhanced delivery of topotecan with a subcutaneously implantable infusion pump by Sonabend, Adam M., Stuart, R. Morgan, Yun, Jonathan, Yanagihara, Ted, Mohajed, Hamed, Dashnaw, Steven, Bruce, Samuel S., Brown, Truman, Romanov, Alex, Sebastian, Manu, Arias-Mendoza, Fernando, Bagiella, Emilia, Canoll, Peter, Bruce, Jeffrey N.

“…Intracerebral convection-enhanced delivery (CED) of chemotherapeutic agents currently requires an externalized catheter and infusion system, which limits its…”
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The Role of Regulatory T Cells in Malignant Glioma by SONABEND, Adam M, ROLLE, Cleo E, LESNIAK, Maciej S

“…The aggressive nature of gliomas is closely related to their capacity to evade the anti-tumoral immune response. The mechanisms implicated in this phenomenon…”
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A novel adenoviral vector labeled with superparamagnetic iron oxide nanoparticles for real-time tracking of viral delivery by Yun, Jonathan, Sonabend, Adam M, Ulasov, Ilya V, Kim, Dong-Hyun, Rozhkova, Elena A, Novosad, Valentyn, Dashnaw, Stephen, Brown, Truman, Canoll, Peter, Bruce, Jeffrey N, Lesniak, Maciej S

“…Abstract In vivo tracking of gene therapy vectors challenges the investigation and improvement of biodistribution of these agents in the brain, a key feature…”
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ET-57 TOPOISOMERASE II IN PRONEURAL GLIOMAS, A MODULATOR OF TRANSCRIPTION AND A THERAPEUTIC TARGET by Sonabend, A. M., Carminucci, A. S., Amendolara, B., Bansal, M., Praver, M., Realubit, R., Li, H., Karan, C., Banu, M., Lei, L., Califano, A., Canoll, P., Bruce, J.

“…Topoisomerase II (TOP2) is highly expressed on proneural gliomas, but its specific function on these tumors is unknown. We found that TOP2 is expressed in…”
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IMAGE GUIDED RNA-SEQ REVEALS SUBTYPE-SPECIFIC PATTERNS AT THE INFILTRATIVE MARGINS OF GLIOBLASTOMA by Canoll, P., Sims, P., Gil, B., Pisapia, D., Malone, H., Goldstein, H., Lei, L., Sonabend, A., Yun, J., Samanamud, J., Sims, J., Teich, A., Sheth, S., McKhann, G., Sisti, M., Bruce, J.

“…BACKGROUND: The primary treatment of GBM is surgical resection of the contrast enhancing mass, while regions of non-enhancing tumor are left behind, and…”
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GE-12 RADIOGRAPHICALLY-LOCALIZED BIOPSIES REVEAL SUBTYPE-SPECIFIC PATTERNS IN MOLECULAR AND CELLULAR COMPOSITION AT THE INFILTRATIVE MARGINS OF GLIOBLASTOMA by Gill, B., Pisapia, D., Malone, H., Goldstein, H., Lei, L., Sonabend, A., Yun, J., Samanamud, J., Banu, M., Dovas, A., Sims, J., Teich, A., Sheth, S., McKhann, G., Sisti, M., Bruce, J., Sims, P., Canoll, P.

“…Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical resection impossible. The mixture of neoplastic and non-neoplastic…”
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A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma by Sonabend, Adam M, Velicu, Simona, Ulasov, Ilya V, Han, Yu, Tyler, Betty, Brem, Henry, Matar, Majed M, Fewell, Jason G, Anwer, Khursheed, Lesniak, Maciej S

“…Interleukin-12 (IL-12) triggers an antitumoral immune response and an antiangiogenic effect against cancer. In this study, we tested a novel polymeric vehicle…”
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