A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise

Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve similar purposes and offers the advantage of noninvasive collect...

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Bibliographic Details
Published in:	Science translational medicine Vol. 16; no. 763; p. eado5366
Main Authors:	Cho, Soongwon, Shaban, Samy M, Song, Ruihao, Zhang, Haohui, Yang, Dasom, Kim, Min-Jae, Xiong, Yirui, Li, Xiuyuan, Madsen, Kenneth, Wapnick, Sarena, Zhang, Shifan, Chen, Ziyu, Kim, Jiwon, Guinto, Gianna, Li, Michelle, Lee, Minkyu, Nuxoll, Ravi F, Shajari, Shaghayegh, Wang, Jin, Son, Seongeun, Shin, Jihoon, Aranyosi, Alexander J, Wright, Donald E, Kim, Tae-Il, Ghaffari, Roozbeh, Huang, Yonggang, Kim, Dong-Hwan, Rogers, John A
Format:	Journal Article
Language:	English
Published:	United States 04-09-2024
Subjects:	Adult Biomarkers - blood Biomarkers - metabolism Exercise - physiology Female Humans Hydrogen-Ion Concentration Lactic Acid - blood Lactic Acid - metabolism Male Microfluidics - methods Skin - metabolism Sweat - chemistry Sweat - metabolism Wearable Electronic Devices
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Summary:	Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve similar purposes and offers the advantage of noninvasive collection and continuous monitoring. The relationship between blood lactate and dynamic sweat biochemistry for wearable engineering applications in physiological fitness remains poorly defined. Here, we developed a microfluidic wearable band with an integrated colorimetric timer and biochemical assays that temporally captures sweat and measures pH and lactate concentration. A colorimetric silver nanoplasmonic assay was used to measure the concentration of lactate, and dye-conjugated SiO nanoparticle-agarose composite materials supported dynamic pH analysis. We evaluated these sweat biomarkers in relation to blood lactate in human participant studies during cycling exercise of varying intensity. Iontophoresis-generated sweat pH from regions of actively working muscles decreased with increasing heart rate during exercise and was negatively correlated with blood lactate concentration. In contrast, sweat pH from nonworking muscles did not correlate with blood lactate concentration. Changes in sweat pH and blood lactate were observed in participants who did not regularly exercise but not in individuals who regularly exercised, suggesting a relationship to physical fitness and supporting further development for noninvasive, biochemical fitness evaluations.
ISSN:	1946-6242
DOI:	10.1126/scitranslmed.ado5366