Search Results - "Son, Seohyun"
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Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines
Published in Journal of enzyme inhibition and medicinal chemistry (01-12-2023)“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) protein tyrosine kinases co-expressed in various cancers such as…”
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Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives
Published in Pharmaceuticals (Basel, Switzerland) (28-12-2022)“…Co-expression of the epidermal growth factor receptor (EGFR, also known as ErbB1) and human epidermal growth factor receptor 2 (HER2) has been identified as a…”
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Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
Published in Angewandte Chemie International Edition (23-09-2013)“…Tracking the target: To identify a protein that binds directly to the HIF‐1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable…”
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Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors
Published in European journal of medicinal chemistry (21-03-2014)“…In order to identify the inhibitors of hepatitis C virus (HCV) replication with a novel scaffold via a mechanistically unbiased approach, we screened our…”
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FRI096 - A randomized, double-blind, placebo-controlled, first-in-human single ascending dose, multiple ascending dose, and food effect study to evaluate the safety, tolerability, and pharmacokinetic profile of FM101 in healthy volunteers
Published in Journal of hepatology (01-08-2020)Get full text
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A randomized, double-blind, placebo-controlled, first-in-human single ascending dose, multiple ascending dose, and food effect study to evaluate the safety, tolerability, and pharmacokinetic profile of FM101 in healthy volunteers
Published in Journal of hepatology (01-08-2020)Get full text
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Identification of Malate Dehydrogenase2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
Published in Angewandte Chemie International Edition (23-09-2013)“…Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable…”
Get full text
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Synthesis and Structure-Activity Relationship of Novel Indole Acrylamide Derivatives as HCV Replication Inhibitors
Published in Bulletin of the Korean Chemical Society (01-01-2015)“…A series of indole acrylamide derivatives were synthesized and evaluated for their inhibitory effects on hepatitis C virus (HCV) replication. Previously, we…”
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Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
Published in Angewandte Chemie (23-09-2013)“…Auf der Jagd: Um ein Protein zu identifizieren, das direkt an den HIF‐1α‐Inhibitor LW6 bindet, wurde eine Reihe neuer chemischer Sonden mit einer…”
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Identification of Malate Dehydrogenase2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
Published in Angewandte Chemie (23-09-2013)Get full text
Journal Article